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| 1 | Establishing the presence or absence of chronic kidney disease:Uses and limitations of formulas estimating the glomerular filtration rate显示文摘The development of formulas estimating glomerular filtration rate(eG FR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease(CKD),which is based on e GFR values and albuminuria.This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based e GFR values and between e GFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all e GFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects, e.g., those with hyperfiltration, and poor prediction of the course of CKD. Research efforts in CKD are currently directed towards identification of biomarkers that are better indices of GFR than the current biomarkers and,particularly, biomarkers of early renal tissue injury. | Ahmed Alaini Deepak Malhotra Helbert Rondon-Berrios Christos P Argyropoulos Zeid J Khitan Dominic SC Raj Mark Rohrscheib Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Methodology2017，7，3： | 7 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | 全科住院医生以患者为中心使用电子病历的干预前后比较研究显示文摘目的目前,临床接诊时常用到电子病历(EHR)。由于使用EHR能给医患关系带来不利影响,因此就'以患者为中心'使用HER已发表了相关推荐方案。然而,当前培训对提高临床接诊EHR应用率的效果尚不明确。本研究旨在调查培训对全科住院医生使用EHR时与患者沟通技巧的影响,并探究其沟通技巧是否因接诊内容而变化。方法本研究在瑞士日内瓦大学医院全科医学科进行,研究对象为全科住院医生。干预措施为为期3个月的培训,包括基于观看接诊录像进行的2个大型的小组培训以及2~4个个性化辅导培训。使用自填式问卷调查全科住院医生对使用EHR的态度。使用Roter沟通互动分析系统以及EHR具体项目评估干预前后全科住院医生执业的情况。干预效果以全科住院医生对使用EHR的态度和在接诊过程前10 min内客观需要使用EHR的情况进行评价。结果招募的27名全科住院医生有17名参与了本研究。研究对象在约30%的接诊里应用了EHR。干预后,认为使用EHR使医患关系变差的全科住院医生数量减少,而且其能够更加放松地使用EHR。全科住院医生使用光标定位EHR的比例在干预后有所增加[干预前:0.77(SD=1.69);干预后:1.80(SD=3.35),P=0.035]。当接诊社会心理疾病的患者时,全科住院医生使用EHR的比例下降(干预前:24.5%,干预后:9.76%,P<0.001)。结论本研究表明,培训可提高全科住院医生接诊时使用EHR的沟通技巧,与敏感的社会心理疾病患者的沟通改善尤其显著。今后,相关的研究可侧重于以患者视角探讨全科医生沟通技巧与其关联性,以及这些沟通技巧的有效性。 | LANIER C DOMINIC DAO M HUDELSON P 本刊编辑部 | 2017 | 中国全科医学2017，20，26： | 2 |
| 4 | Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation显示文摘 | Murray J A Kiran D K A Dominic P G | 2009 | Thrombosis Research2009，124，6： | 1 |
| 5 | Structure of biologically active muramyl peptides from peptidoglycan of Streptococcum Sanguis显示文摘 | SARKA B DOMINIC M D MICHAEL J P | 1998 | J Mass Spectrom1998，33，： | 1 |
| 6 | Interleukin 6 modulates hepatic and muscle protein synthesis during hemodialysis显示文摘 | Raj DS Moseley P Dominic EA | 2008 | Kidney Int2008，73，： | 1 |
| 7 | A structural equation modeling approach for the adoption of cloud computing to enhance the Malaysian Healthcare Sector显示文摘 | Ratnarn K A Dominic P D D Ramayah T | 2014 | Journal of medical systems2014，38，8： | 1 |
| 8 | RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardio- myocyte apoptosis显示文摘 | Dominic P Del R Miyamoto S | 2007 | Biol Chem2007，282，11： | 1 |
| 9 | Biweekly docetaxel and gemcitabine as neoadjuvant chemotherapy in stage Ⅱ and Ⅲ breast cancer patients: Preliminary results of a phase II and pharmacogenomic study 显示文摘 | Estevez LG Sanchez-Rovira P Domine M | 2004 | Semin Oncol2004，31，： | 1 |
| 10 | Kinetics of hexane pyrolysis at very high pressures显示文摘 | DOMINE F MARQUIRE P M MULLER C | 1990 | Energy & Fuels1990，4，1： | 1 |
| 11 | Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha (2)-glycoprotein显示文摘 | Russell S T Zimmerman T S P Domin B A | 2004 | BBA-Molecular and Cell Biology of Lipids2004，1636，1： | 1 |
| 12 | To- wards iron-catalysed suzuki biaryl cross-coupling:Un- usual reactivity of 2-halobenzyl halides 显示文摘 | Robin B B Timothy G Dominic R P | 2015 | Synthe- sis2015，47，12： | 1 |
| 13 | Emergence of fluoroquinolone resistance among multiply resistant strsins of Streptococcus peumoniae in Hong Kong 显示文摘 | Ho P L Que T L Dominic N C | 1999 | Antimicrobial Agents Chemother1999，43，5： | 1 |
| 14 | Gas sensing using porous materials for automotive applications显示文摘 | Dominic J Wales Julien Grand Valeska P Ting | 2015 | Chem Soc Rev2015，44，： | 1 |
| 15 | 3466 a prospec- tive trial of proximal femoral nail versus dynamic hip screw for unstable and complex intertrochanteric fractures of the femur 显示文摘 | Arshad B Dominic P Sohail Q | 2004 | Bone Joint Surg Proceedings (Br)2004，86，： | 1 |
| 16 | Fourbarley genotypes respond differently to cadmium: lipid peroxidation and activities of antioxidant capacity显示文摘 | WU F B ZHANG G P DOMIN Y P | 2003 | Environmental and Experimental Botany2003，50，2： | 1 |
| 17 | Mechanistic modeling of the thermal cracking of tetralin显示文摘 | BOUNACEUR R SCACCHI G MARQUAIRE P M DOMIN F | 2000 | Ind Eng Chem Res2000，39，11： | 1 |
| 18 | Data sharing and intellectual property in a genomic epidemiology network: Policies for large - scale research collaboration 显示文摘 | Dave A Chokshi Michael Parker Dominic P Kwiatkowski | 2006 | Bulletin of the World Health Organization2006，84，5： | 1 |
| 19 | Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function显示文摘 | James P Cleary Dominic M Walsh Jacki J Hofmeister | 2005 | Nat N eurosci2005，8，1： | 1 |
| 20 | Efficient Dispatching Rules for Dynamic Job Shop Scheduling显示文摘 | Dominic P D D Kaliyamoorthy S Kumar S M | 2004 | International Journal of Advanced Manufacturing Technology2004，24，12： | 1 |
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