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| 1 | Predicting early outcomes of liver transplantation in young children: The EARLY study显示文摘AIM To determine potentially modifiable predictors of early outcomes after liver transplantation in children of age < 3 years.METHODS This study was a retrospective chart review including all consecutive children of age less than 3-years-old having had a liver transplant done at the Western Canadian referral center from June 2005 to June 2015.Pre-specified potential predictor variables and primary and secondary outcomes were recorded using standard definitions and a case report form. Associations between potential predictor variables and outcomes were determined using univariate and multiple logistic [odds ratio(OR); 95%CI] or linear(effect size, ES; 95%CI) regressions. RESULTS There were 65 children, of mean age 11.9(SD 7.1) mo and weight 8.5(2.1) kg, with biliary-atresia in 40(62%), who had a living related donor [LRD; 29(45%)], split/reduced [21(32%)] or whole liver graft [15(23%)]. Outcomes after liver transplant included: ventilator-days of 12.5(14.1); pediatric intensive care unit mortality of 5(8%); re-operation in 33(51%), hepatic artery thrombosis(HAT) in 12(19%), portal vein thrombosis(PVT) in 11(17%), and any severe complication(HAT, PVT, bile leak, bowel perforation, intraabdominal infection, retransplant, or death) in 32(49%) patients. Predictors of the prespecified primary outcomes on multiple regression were:(1) HAT: split/reduced(OR 0.06; 0.01, 0.76; P = 0.030) or LRD(OR 0.16; 0.03, 0.95; P = 0.044) vs whole liver graft; and(2) ventilator-days: surgeon(P < 0.05), lowest antithrombin(AT) postoperative day 2-5(ES-0.24;-0.47,-0.02; P = 0.034), and split/reduced(ES-12.5;-21.8,-3.2; P = 0.009) vs whole-liver graft. Predictors of the pre-specified secondary outcomes on multiple regression were:(1) any thrombosis: LRD(OR 0.10; 0.01, 0.71; P = 0.021) or split/reduced(OR 0.10; 0.01, 0.85; P = 0.034) vs whole liver graft, and lowest AT postoperative day 2-5(OR 0.93; 0.87, 0.99; P = 0.038); and(2) any severe complication: surgeon(P < 0.05), lowest AT postoperative day 2-5(OR 0.92; 0.86-0.98; P = 0.016), and split/reduced(OR 0.06; 0.01, 0.78; P = 0.032) vs whole-liver graft. CONCLUSION In young children, whole liver graft and surgeon was associated with more complications, and higher AT postoperative day 2-5 was associated with fewer complications early after liver transplantation. | Rashid Alobaidi Natalie Anton Dominic Cave Elham Khodayari Moez Ari R Joffe | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Up to what temperature is petroleum satble? New insights from a 5200 free radical reaction model显示文摘 | Domine F Bounaceur R Scacchi G | 2002 | Organic Geochemistry2002，33，： | 1 |
| 3 | Genetic reinforcement learning for neurocontrol problem显示文摘 | Whiltley D Dominic S Das R | 1993 | Machine Learning1993，13，： | 1 |
| 4 | 110W fibre laser显示文摘 | V Dominic S MacCormack R Waarts | 1999 | Electronics Letters1999，35，14： | 1 |
| 5 | Electrospun poly( ε-caprolae- tone) -based skin substitutes : In vivo evaluation of wound healing and the mechanism of cell proliferation 显示文摘 | Augustine R Dominic EA Reju I | 2015 | J Biomed Mater Res B Appl Biomater2015，103，7： | 1 |
| 6 | 110 W fiber laser显示文摘 | DOMINIC V MACCORMACK S WAARTS R | 1999 | Elcectron Lett1999，35，14： | 1 |
| 7 | 100 W fiber laser显示文摘 | DOMINIC V MACCORMACK S WAARTS R | 1999 | Electron Lett1999，35，14： | 1 |
| 8 | 110 W fibrelaser 显示文摘 | V Dominic S MacCormack R Waarts | 1999 | Electron Lett1999，35，14： | 1 |
| 9 | Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway显示文摘 | Annamaria R Badarch U Dominic A | 2002 | Cancer Res2002，62，15： | 1 |
| 10 | RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardio- myocyte apoptosis显示文摘 | Dominic P Del R Miyamoto S | 2007 | Biol Chem2007，282，11： | 1 |
| 11 | Use of CAD/CAM technology to fabricate a removable partial denture framework显示文摘 | Williams R J Bibb Richard Eggbeer Dominic | 2006 | The Journal of prosthetic dentistry2006，96，2： | 1 |
| 12 | Use of CAD/CAM technology to fabricate a removable partial den- ture Framework显示文摘 | Williams R J Richard Bibb Dominic Eggbeer | 2006 | The Journal of Prosthetic Dentistry2006，96，2： | 1 |
| 13 | Comparative studies of CO and H2O interactions with Pd(111) surface:A theoretical study of poisoning显示文摘 | Dominic R A | 2006 | Appl Phys Lett2006，88，05： | 1 |
| 14 | 110 W fiber laser 显示文摘 | DOMINIC V MAC CORMACK S WAARTS R | 1999 | Electron Lett1999，35，14： | 1 |
| 15 | 110W fiber laser显示文摘 | DOMINIC V MacCORMACK S WAARTS R | 1999 | Electron Lett1999，35，14： | 1 |
| 16 | Prevalence of depression in consecutive patients with type 2 diabetes mellitus of 5-year duration and its impact on glycemic control显示文摘 | MATHEW C S DOMINIC M ISAAC R | 2012 | Indian Journal of Endocrinology & Metabolism2012，16，5： | 1 |
| 17 | Genetic reinforcement learning for neurocontrol problem 显示文摘 | Whiltley D Dominic S Das R | 1993 | Machine Learning1993，13，23： | 1 |
| 18 | To- wards iron-catalysed suzuki biaryl cross-coupling:Un- usual reactivity of 2-halobenzyl halides 显示文摘 | Robin B B Timothy G Dominic R P | 2015 | Synthe- sis2015，47，12： | 1 |
| 19 | 110 W fibre laser显示文摘 | DOMINIC V MACCORMACK S WAARTS R | 1999 | Electronics Letters1999，35，14： | 1 |
| 20 | DART-MS as a preliminary screening method for 'herbal incense': chemical analysis of synthetic canna- binoids显示文摘 | LESIAK A D MUSAH R A DOMIN M A | 2014 | Forensic Sciences2014，59，2： | 1 |
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