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11篇 您的检索式：作者名="Dominijanni"

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		题名	作者	年代	出处	被引量
	1	Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations显示文摘Aim:Resistance to fluoropyrimidine drugs(FPs)is a major cause of mortality in colorectal cancer(CRC).We assessed the potency advantage of the polymeric FP F10 relative to 5-fluorouracil(5-FU)in four human CRC cell lines that differ only in TP53 mutational status to determine how p53 mutations affect drug response and whether F10 is likely to improve outcomes.Methods:HCT-116 human CRC cells(p53^(+/+))and three isogenic variants(p53^(-/-),R248W/+,R248W/-)were assessed for drug response.Resistance factors were derived from cell viability data and used to establish the relative potency advantage for F10.Rescue studies with exogenous uridine/thymidine determined if cytotoxicity resulted from DNA-directed processes.Results:Significant resistance to 5-FU resulted from p53-loss or from gain-of-function(GOF)mutation(R248W)and was greatest when GOF mutation was coupled with loss of wild-type p53.F10 is much more potent than 5-FU(137-314-fold depending on TP53 mutational status).F10 and 5-FU induce apoptosis by DNA-and RNA-directed mechanisms,respectively,and only F10 shows a modest enhancement in cytotoxicity upon co-treatment with leucovorin.Conclusion:TP53 mutational status affects inherent sensitivity to FPs,with p53 GOF mutations most deleterious.F10 is much more effective than 5-FU regardless of TP53 mutations and has potential to be effective to CRC that is resistant to 5-FU due,in part,to TP53 mutations.	Anthony Dominijanni William H.Gmeiner	2018	Cancer Drug Resistance2018，1，1：	2
	2	Modelling the osmosis effect on solute migration through porous media 显示文摘	Manassero M Dominijanni A	2003	Geotechnique2003，53，：	1
	3	Modelling the osmosis effect on solute migration through porous media显示文摘	MANASSERO M DOMINIJANNI A	2003	Geoteehnique2003，53，：	1
	4	Modelling the osmosis effect on solute migration through porous media显示文摘	MANASSERO M DOMINIJANNI A	2003	Géotechnique2003，53，5：	1
	5	Modelling osmosis and solute transport through clay membrane barriers显示文摘	DOMINIJANNI A MANASSERO M	2005	Geotechnical Special Publication2005，130，142：	1
	6	Fabrication of Schottky diodes for terahertz imaging显示文摘	Giovine E Casini R Dominijanni D		0，，：	1
	7	Basilic veintransposition versus biosynthetic prosthesis as vascular accessfor hemodialysis显示文摘	Morosetti M Cipriani S Dominijanni S	2011	J Vase Surg2011，54，6：	1
	8	Modelling the osmosis effect on solute migration through porous media显示文摘	Manassero M Dominijanni A	2003	Geotechnique2003，53，：	1
	9	Deletion polymorphism in the gene for angiotensin concerting enzyme is associated with elevated fasting blood glucose levels显示文摘	Zingone A Dominijanni A Mele E		Hum Genet0，94，2：	1
	10	Enantioselective effects of levodropropizine and dropropizine on psychomotor functions in normal volunteers:A placebo-controlled,doubleblind comparative study显示文摘	GATTI G BARZAGHI N DOMINIJANNI R	1993	Drugs Exp Clin Res1993，19，1：	1
	11	Modelling the osmosis effect on solute migration through porous media显示文摘	MANASSERO M DOMINIJANNI A	2003	G6oteehnique2003，53，5：	1

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