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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | Effects of the PPARγ agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus显示文摘 | Nagashima K Lopez C Donovan D | 2005 | Clin Invest2005，115，： | 1 |
| 4 | Gastric emptying in diabetes: clinical significance and treatment 显示文摘 | Horowitz M O'Donovan D Jones KL | 2002 | Diabet Med2002，19，3： | 1 |
| 5 | Genome-wide analysis of histone modifications by ChiP-on-chip显示文摘 | Huebert D J Kamal M O'Donovan A | 2006 | Methods2006，40，4： | 1 |
| 6 | Severe thrombocyto-penia predicts outcome in neonates with necrotizing enterocolitis显示文摘 | Kenton AB 0'Donovan D Cass DL | 2005 | J Perinatol2005，25，1： | 1 |
| 7 | Morphological phy- logenetics of termites (Isoptera) 显示文摘 | Donovan S E Jones D T Sands W A | 2000 | Biological Journal of the Linnean Society2000，70，3： | 1 |
| 8 | The effect of the nitrification inhibitor dicyandiamide (DCD) on herbage production when applied at different times and rates in the autumn and winter显示文摘 | O'Connor PJ Hennessy D Brophy C O'Donovan M Lynch MB | 2012 | Agricultural Ecosystems & Environment2012，152，： | 1 |
| 9 | Comment on ' Green Space, health inequality, and pregnancy'显示文摘 | Donovan G H Michael Y L Butry D T | 2012 | Environ Int2012，39，1： | 1 |
| 10 | Comparison of trends in prostatecancer mortality in English and Wales and the USA显示文摘 | Oliver SE Gunnell D Donovan JL | 2000 | Lancet2000，355，： | 1 |
| 11 | Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome显示文摘 | Whorwood CB Donovan SJ Flanagan D | 2002 | Diabetes2002，51，4： | 1 |
| 12 | Activity of dasatinib with chemotherapy in triple -negative breast cancer cells显示文摘 | Tryfonopoulos D O Donovan N Corkery B | 2009 | J Clin Oncol (Meeting Abstracts)2009，27，14： | 1 |
| 13 | The phage K lyric enzyme LysK and lysostaphin act synergistically to kill MRSA显示文摘 | Becker S C Foster-Frey J Donovan D M | 2008 | Ferns Microhiol Lett2008，287，2： | 1 |
| 14 | Idiopathic and diabetic gastroparesis显示文摘 | O'Donovan D Feinle- Bisset C Jones K | 2003 | Curr Treat Options Gastroenterol2003，6，： | 1 |
| 15 | Signaling pathways involved in thrombin-induced cell protection 显示文摘 | Donovan F M Cunningham D D | 1998 | J Biol Chem1998，273，12： | 1 |
| 16 | Vitamin D and calcium dysregulation in the polycystic ovarian syndrome 显示文摘 | Thys-Jacobs S Donovan D Papadopoulos A | 1999 | Steroids1999，64，6： | 1 |
| 17 | Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge显示文摘 | Donovan E L McCord J M Reuland D J | 2012 | Oxid Med Cell Longev2012，2012，13： | 1 |
| 18 | Comparison of trends in prostate cancer mortality in England and Wales and the USA显示文摘 | Oliver E GunneU D Donovan JL | 2000 | Lancet2000，355，6： | 1 |
| 19 | Tumors of the parapharyngeal space 显示文摘 | Shoss S M Donovan D T Alford B R | 1985 | Arch Otolaryngal1985，111，11： | 1 |
| 20 | Introduction of sense constructs of cinnamate 4-hydroxylase (CYP73A24) in transgenic tomato plants shows opposite effects on flux into stem lignin and fruit flavonoids显示文摘 | Millar D J Long M Donovan G | 2007 | Phytochemistry2007，68，11： | 1 |
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