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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | 终末期肾病患者大血管和微血管内皮功能障碍与亚临床心功能不全的关系显示文摘终末期肾病(end-stagerenaldisease,ESRD)患者的心脏衰竭和心血管病死亡率较高,而我们对此缺乏深入透彻的了解,是否存在可变因素导致了这些高危患者发生心功能不全。为了评估血管内皮功能能否作为ESRD患者潜在的心功能不全的可变因素,研究人员应用横断面研究在一个控制良好的ESRD队列中,分析大血管和微血管功能障碍与左、右心功能不全的相关性。 | 刘莉 叶鹏 Dubin RF Guajardo I Ayer A Mills C Donovan C Beussink L Scherzer R Ganz P Shah SJ | 2016 | 中华高血压杂志2016，24，9： | 5 |
| 3 | Neurophysio- logical approaches to chronic pain following spinal cord injury显示文摘 | Donovan W Dimitrijevic M Dahm L | 1982 | Paraplegia1982，20，3： | 1 |
| 4 | Comment on ' Green Space, health inequality, and pregnancy'显示文摘 | Donovan G H Michael Y L Butry D T | 2012 | Environ Int2012，39，1： | 1 |
| 5 | Pharmacokinetics and metabolism of dietary flavonoids in humans显示文摘 | MANACH C DONOVAN J L | 2004 | Free Radical Research2004，38，8： | 1 |
| 6 | Synthesis of Well-defined, Stimuli-responsive,Water-soluble Polymers via the RAFT Process 显示文摘 | Donovan M S Lowe A B McCormick C L | 1999 | Polym Prep1999，40，2： | 1 |
| 7 | Spectacle lenses de-signed to reduce progression of myopia:12-month results显示文摘 | Sankaridurg P Donovan L Varnas S | 2010 | Optom Vis Sci2010，87，9： | 1 |
| 8 | Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge显示文摘 | Donovan E L McCord J M Reuland D J | 2012 | Oxid Med Cell Longev2012，2012，13： | 1 |
| 9 | Efficient soybean transformation using hygromycin B selection in the cotyledonarynode method显示文摘 | Olhoft P M Flagel L E Donovan C M | 2003 | Planta2003，216，5： | 1 |
| 10 | Cytokine and chemokine profiles in multiple myeloma:significance of stromal interaction and correlation of IL-8 production with disease progression显示文摘 | Kline M Donovan K Wellik L | 2007 | Leuk Res2007，31，： | 1 |
| 11 | Effect of salinity on grain yield and quality, vegetative growth and germination of emidwarf and durum wheat显示文摘 | Francois L E Maas E V Donovan T J | 1986 | Agronomy Journal1986，78，6： | 1 |
| 12 | Efficient soybean transformation using hygromycin B selection in the cotyledonarynode method显示文摘 | Olhoft P M Flagel L E Donovan C M | | 0，，： | 1 |
| 13 | Predawn disequilibrium between plant and soil water potentials in two cold-desert shrubs 显示文摘 | DONOVAN L A GRISE D J WEAT J B | 1999 | Oecologia1999，120，： | 1 |
| 14 | Efficient soybean transformation using hyg~omycin B selection in the cotyledon- aft-node method 显示文摘 | Olhoft P M Flagel L E Donovan C M | 2003 | Planta2003，216，5： | 1 |
| 15 | Aeromagnetic detection of diagenetic magnetite over oil field显示文摘 | Donovan T J Forgey R L Roberts A A | 1979 | AAPG1979，63，： | 1 |
| 16 | A randomized trial comparing transurethral resection of the prostate, laser therapy and conservative largment:the claspstudy显示文摘 | Donovan J L Peters T J Neal D E | 2000 | J Urol2000，164，： | 1 |
| 17 | Efficient soybean transformation using hygromycin B selection in the cotyledonary node method显示文摘 | OLHOFT P M FLAGEL L E DONOVAN C M | 2003 | Planta2003，5，： | 1 |
| 18 | Water potential and ionic effects on germination and seedling growth of two cold desert shrubs显示文摘 | Dodd G L Donovan L A | 1999 | Am J Bot1999，86，： | 1 |
| 19 | Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers显示文摘 | DeVane C L Donovan J L Liston H L | 2004 | J Clin Psychopharmacol2004，24，1： | 1 |
| 20 | Efficient soybean transformation using hygromycin B selection in the cotyledonary- node method 显示文摘 | Olhoft P M Flagel L E Donovan C M | 2003 | Planta2003，5，： | 1 |
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