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| 1 | Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model显示文摘Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer. | Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim Kim Kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang Min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，12： | 2 |
| 2 | Low Concentration Monitoring of Exhaust Gases Using a UV-based Optical Sensor 显示文摘 | DOOLY G LEWIS E FITZPATRICK C | 2007 | IEEE Sensors Journal2007，7，5： | 1 |
| 3 | Analysis of polycyclic aromatic hydrocarbons, phenols and aromatic amines in particulate phase cigarette smoke using simultaneous distillation and extraction as a sole sample clean-up step 显示文摘 | Forehand J B Dooly G L Moldoveanu S C | 2000 | JOURNAL OF CHROMATOGRAPHY A2000，898，： | 1 |
| 4 | Analog modeling of pull-apart Basins显示文摘 | Dooly T McClay K | 1997 | AAPG1997，81，11： | 1 |
| 5 | New technique using solid-phase extraction for the analysis of aromatic amines in mainstream cigarette smoke显示文摘 | Smith C J Dooly G L Moldoveanu S C | 2003 | JOURNAL OF CHROMATOGRAPHY A2003，991，： | 1 |
| 6 | Process Quality Knowledge Bases 显示文摘 | DOOLY K ANDERSON J LIU X H | 2000 | Journal of Quality Management2000，4，2： | 1 |
| 7 | Hypertension bring it down with exercise显示文摘 | Dooly C | 2003 | J American College of Sports Medicine2003，4，： | 1 |
| 8 | Analysis of polycyclic aromatic hydrocarbons, phenols and aromatic amines in particulate phase cigarette smoke using simultaneous distillation and extraction as a sole sample clean-up step 显示文摘 | FOREHAND J B DOOLY G L MOLDOVEANU S C | 2000 | Journal of Chromatography A2000，898，1： | 1 |
| 9 | Analysis of polycyclic aromatic hydrocarbons, phenols and aromatic amines in particulate phase ciga- rette smoke using simultaneous distillation and ex- traction as a sole sample clean-up step显示文摘 | FOREHAND J B DOOLY G L MOLDOVEANU S C | 2000 | Journal of Chromatography A2000，898，： | 1 |
| 10 | Analysis of polycyclic aromatic hydrocarbons, phenols and aromatic amines in particulate phase cigarette smoke using simultaneous distillation and extraction as a sole sample clean-up step显示文摘 | FOREHAND J B DOOLY G L MOLDOVEANU S C | 2000 | J Chromatogr: A2000，898，1： | 1 |
| 11 | Appropriate Controls for Phosphate Boiler Water Treatments to Avoid Acid Phosphate Corrosion and Hydrogen Damage显示文摘 | Barry Dooly Warren P McNaughon | 2001 | Power Plant Chemistry2001，3，3： | 1 |
| 12 | Analysis of polycyclic aromatic hydrocarbons,phenols and aromatic amines in particulate phase cigarette smoke using simultaneous distillation and extraction as a sole sample clean-up step显示文摘 | FOREHAND J B DOOLY G L MOLDOVEANU S C | 2000 | Journal of Chromatography A2000，898，1： | 1 |
| 13 | New competencies in a new eraExamining the impact of a teacher training project显示文摘 | Dooly M | 2009 | Re CALL2009，21，3： | 1 |
| 14 | A shift-based sequencing method for twin-shuttle automated storage and retrieval systems显示文摘 | DOOLY D R LEE H F | 2008 | IIE Transactions2008，40，6： | 1 |
| 15 | Low concentration monitoring of exhaust gases using a UV-based optical sensor显示文摘 | Dooly G Lewis E Fitzpatrick C | 2007 | IEEE Sensors Journal2007，7，5： | 1 |
| 16 | Understanding the many steps for effective collaborative language projects 显示文摘 | Dooly M | 2008 | Language Learning Journal2008，，1： | 1 |
| 17 | Amar multiple instance learning of real-valued data 显示文摘 | Dooly D R Zhang Q Goldman S A | 2002 | The Journal of Machine Learning Research2002，3，： | 1 |
| 18 | Deep UV based DOAS system for the monitoring of nitric oxide using ratiometric separation techniques 显示文摘 | DOOLY G FITZPATRICK C LEWIS E | 2008 | Sensors and Actuators B2008，134，： | 1 |
| 19 | Analog modeling of pull-apart basins显示文摘 | Dooly T Mc Clay K | 1997 | AAPG Bulletin1997，81，11： | 1 |
| 20 | Analog modeling of pull-apart Basins显示文摘 | Dooly T McClay K | 1997 | AAPG1997，81，11： | 1 |
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