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| 1 | Modulations of genes related to gut integrity,apoptosis,and immunity underlie the beneficial effects of Bacillus amyloliquefaciens CECT 5940 in broilers fed diets with different protein levels in a necrotic enteritis challenge model显示文摘Background:The ban of in-feed antimicrobial additives has negatively affected the poultry industry by causing necrotic enteritis(NE)to emerge in the flocks.Alternatives such as Bacillus probiotics have shown to be effective on eliminating the negative effects of this disease.Two experiments were conducted to investigate the effect of Bacillus amyloliquefaciens CECT 5940(BA)in broiler chickens under NE challenge and/or fed diets with different protein levels.Methods:In both experiments,480 day-old mix-sexed Ross-308 broilers were arranged in a 2×2 factorial arrangement of treatments.In experiment 1,the factors were NE challenge(yes or no)and probiotic(yes or no).In experiment 2,the factors were dietary crude protein levels(standard or reduced)and probiotic(yes or no)and were used under NE challenge condition.Oral administration of Eimeria oocysts(day 9)followed by inoculation with Clostridium perfringens(day 14 and 15)was used to induce NE challenge.On day 16,two birds from each treatment were gavaged with fluorescein isothiocyanate-dextran(FITC-d)and blood samples were collected for gut integrity evaluation,and jejunal samples were collected for gene expression assay.Results:In experiment 1,BA supplementation decreased caspase-3(CASP3)(P<0.001)and caspase-8(CASP8)(P<0.05)and increased occludin(OCLD)(P<0.05)expression regardless of the challenge.Additionally,BA supplementation downregulated interfron-γ(IFN-γ)expression(P<0.01)and upregulated immunoglobulin-G(IgG)(P<0.01)and immunoglobulin-M(IgM)(P<0.05)only in challenged birds.In experiment 2,the expression of genes encoding mucin-2(MUC2)(P<0.001),tight junction protein-1(TJP1)(P<0.05)and OCLD(P<0.05)were upregulated by the addition of BA in the diet,regardless of the crude protein level.Further,BA supplementation downregulated INF-γ(P<0.01)and upregulated immunoglobulin-A(IgA)(P<0.05),IgM(P<0.05)and IgG(P<0.01)regardless of the crude protein level.Conclusion:These findings suggest that supplementation of BA in broiler diets can improve gut health by modulation of genes related to the mucosal barrier,tight junction,and immunity in broilers challenged by unfavourable conditions such as NE challenge. | Kosar Gharib-Naseri Juliano Cesar de Paula Dorigam Kiran Doranalli Sarbast Kheravii obert A.Swick Mingan Choct Shu-Biao Wu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 6 |
| 2 | The effect of vitreous and retinal surgery on corneal endothelial cell density 显示文摘 | Friberg TR Doran DL Lazenby FL | 1984 | Ophthalmology1984，91，： | 2 |
| 3 | 接受患者自我管理教育的基层医务人员是否能改善患者结局的系统综述显示文摘背景对患者自我管理给予支持是慢性病管理的一项重要内容。研究表明,对医务人员进行自我管理相关的教育和培训可以提高其对自我管理项目的理解、促进项目实施并改善实施效果。然而,此种培训是否能改善慢性病患者的结局,目前尚不清楚。方法采用PRISMA流程进行系统综述。计算机检索6个数据库(Cochrane Library,PubMed,ERIC,EMBase,CINAHL,PsycINFO),并同时应用网络搜索、手动搜索和目录检索方法搜集2013-09-01前发表的报道接受过自我管理继续教育或循证医学/教育的基层医务人员对慢性病患者自我管理的影响的系统综述、Meta分析、随机对照试验、中断时间序列分析、前-后对照研究。流程的每一环节均至少由2位研究人员分别独自进行。结果共检索7 533篇相关文献的摘要。仅2篇随机对照试验报道了经过相关教育和培训的基层医务人员对慢性背痛患者和糖尿病患者进行自我管理教育支持后,经科学评估,这些患者的结局得到了改善。这2篇研究中对医务人员进行教育和培训的内容除了涉及患者自我管理方面的技能和方式之外,还包含了动机访谈培训。结论在WONCA欧洲区域组织将患者自我管理能力纳入全科医生的工作内容之前和之后的两年期间,慢性病患者自我管理能力在得到受过相关教育和培训的医务人员的帮助后,得到了提高,从而使得患者结局得到了改善,但是这种论断仍然需要高质量的研究支持。 | ROCHFORT A BERINE S DORAN G 本刊编辑部 | 2018 | 中国全科医学2018，21，32： | 2 |
| 4 | Inducible nitric oxide synthase and histopathological correlation in chronic viral hepatitis显示文摘 | Esin Atik Yusuf Onlen Lutfu Savas Figen Doran | 2007 | International Journal of Infectious Diseases2007，，1： | 2 |
| 5 | Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section显示文摘 | Jerome Dansereau Arvind K. Joshi Michael E. Helewa Terence A. Doran Ian R. Lange Edwin R. Luther Dan Farine Miklos L. Schulz Gwendolyn L.A. Horbay Patricia Griffin Willem Wassenaar | 1999 | American Journal of Obstetrics and Gynecology1999，，3： | 2 |
| 6 | 羊毛用耐缩绒酸性染料和1:2-金属络合染料低温染色工艺的最新发展显示文摘引言 羊毛的低温染色是数十年来世界性研究的课题,实际上,早在30年代就有人认识到羊毛的染色条件对纤维的损害超过了棉纤维在染色时的损伤。从那之后,对低温染色做了许多的研究工作。 | A Doran 陈水林 | 1994 | 国外纺织技术(化纤.染整.环境保护分册)1994，0，2： | 2 |
| 7 | MR imaging of anisotropically restricted diffusion of water in the nervous system: technical, anatomic, and pathologic considerations显示文摘 | Hajnal JV Doran M Hall AS | 1991 | J Comput Assist Tomogr1991，15，1： | 2 |
| 8 | Soil denitrification - significance,measurement, and effect of management显示文摘 | Aulakh M S Doran J W Mosier A R | 1992 | Advances in Soil Science1992，18，： | 2 |
| 9 | The Information of Historical Cost Earnings Relative to Supplemental Reserve-Based Accounting Data in the Extractive Petroleum Industry显示文摘 | B Michael Doran Daniel W Collins Dan S Dhaliwal | 1988 | The Accounting Review1988，63，3： | 1 |
| 10 | The stimulation of antral motility by erythromycin is attenuated by hyperglycemia显示文摘 | Rayner CK Su YC Doran SM | 2000 | Am J gastroenterol2000，95，9： | 1 |
| 11 | DNA-based diagnostic tests for Salmonella species targeting agfA,the structural gene for thin,aggregative fimbriae显示文摘 | DORAN J L COLLINSON S K BURIAN J | 1993 | J Clin Microbiol1993，31，： | 1 |
| 12 | Soil health and global sustainability:translating scienceinto practice显示文摘 | DORAN J W | 2002 | Agriculture Ecosystems and Environment2002，88，： | 1 |
| 13 | Soil quality: A concept, definition, and framework for evaluation 显示文摘 | KARLEN D L MAUSBACH M J DORAN J W | 1997 | Soil Science Society of America Journal1997，61，1： | 1 |
| 14 | Outcomes after combined modality therapy for EGFR- mutant and wild-type locally advanced NSCLC显示文摘 | Mak RH Doran E Muzikansky A eta/ | 2011 | Oncologist2011，16，6： | 1 |
| 15 | Soil Quality:a Concept,Definition,and Framework for Evaluation显示文摘 | KARLEN D L MAUSBACH M J DORAN J W | 1997 | Soil Science Society of American Journal1997，61，： | 1 |
| 16 | Earnings conference calls and stock returns: The incremental informativeness of textual tone显示文摘 | Price S M Doran J S Peterson D R | 2012 | Journal of Banking & Finance2012，36，4： | 1 |
| 17 | Soil bacterial and biochemical changes associated with reduced tillage显示文摘 | Doran JW | 1980 | Soil Science Society of America Journal1980，44，： | 1 |
| 18 | Soil microbial activity, nitrogen cycting and long-term changes in organic carbon pools as related to fallow tillage management 显示文摘 | Doran J W | 1998 | Soil and Jillage Research1998，49，： | 1 |
| 19 | HLA-DRw7 and steroid- responsive nephrotic syndrome of childhood 显示文摘 | Alfiler CA Roy LP Doran T | 1980 | Clin Nephrol1980，14，2： | 1 |
| 20 | Nonlinear-optical loop mirror显示文摘 | DORAN N J WOOD D | 1988 | Optics Letters1988，13，： | 1 |
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