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| 1 | A study of pulmonary embolism after abdominal surgery in patients undergoing prophylaxis显示文摘AIM:To determine risk factors for pulmonary embolism and estimate effects and benefits of prophylaxis.METHODS:We included 78 patients who died subsequently to a pulmonary embolism after major abdomi nal surgery from 1985 to 2003.A first,retrospective analysis involved 41 patients who underwent elective surgery between 1985 and 1990 without receiving any prophylaxis.In the prospectively evaluated subgroup,37 patients undergoing major surgery between 1991 and 2003 were enrolled:all of them had received a prophylaxis consisting in low-molecular weight heparin,given subcutaneously at a dose of 2850 IU AXa/0.3 mL(body weight < 50 kg) or 5700 IU AXa/0.6 mL(body weight ≥ 50 kg).RESULTS:A higher incidence of thromboembolism(43.9% and 46.34% in the two groups,respectively) was found in older patients(> 60 years).The incidence of pulmonary embolism after major abdominal surgery in patients who had received the prophylaxis was signifi cantly lower compared to the subjects with the same condition who had not received any prophylaxis(P < 0.001,OR = 2.825;95% CI,1.811-4.408).Furthermore,the incidence of pulmonary embolism after colorectal cancer surgery was signifi cantly higher compared to incidence of pulmonary embolism after other abdominal surgical procedures.Finally,the incidence of pulmonary embolism after colorectal cancer surgery among the patients who had received the prophylaxis(11/4316,0.26%) was significantly lower compared to subjects undergoing a surgical procedure for the same indication but without prophylaxis(10/1562,0.64%)(P < 0.05,OR = 2.522;95% CI,1.069-5.949).CONCLUSION:Prophylaxis with low molecular weight heparin is highly recommended during the preoperative period in patients with diagnosis of colorectal cancer due to high risk of pulmonary embolism after elective surgery. | Mirko D Kerkez Dorde M ulafi Dragana D Mija Vitomir I Rankovi Nebja S Leki Dejan Z Stefanovi | 2009 | World Journal of Gastroenterology2009，15，3： | 14 |
| 2 | Polyphenol contents and antioxidant activity of Maydis stigma extracts显示文摘 | Zoran M Dorde M Nada K | 2005 | Bioresour technol2005，96，8： | 1 |
| 3 | Drug-Induced VesselRemodeling in Bone Metastases as Assessed by Dynamic ContrastEnhanced Magnetic Resonance Imaging and Vessel Size Imaging:ALongitudinal In vivo Study显示文摘 | Tobias B Maximilian M Dorde K | 2010 | Clin Cancer Res2010，16，12： | 1 |
| 4 | Spontaneous gastrojejunal fistula is a complication of gastric ulcer显示文摘Spontaneous gastrojejunal fistula formation is an extremely rare complication of gastric ulcer disease. We report a 77-year old woman who presented with diffuse abdominal pain, weight loss, malaise, nausea, and occasional dark stools. Laboratory tests showed extreme hyposideremic anemia with inflammatory syndrome. In addition, biochemical parameters of malnourishmen were presented. Upper endoscopy revealed the paten esophagus along the full length without any pathologica changes. Large and deep ulceration with perforation in the small intestine was detected in the posterior gastric wall. The small intestine loop was reached by endoscope through spontaneously developed gastrojejunal fistula Polytopic biopsies of described ulcerative change were carried out. Histopathologically reepithelialized ulcerous zone was seen in the gastric mucosa. Also gastrojejunal fistula was visualized after wide opening o hepatogastric and gastrocolic ligament. Jejunal loop 25 cm from ligament of Treitz was attached to mesocolon and posterior gastric wall because of ulcer penetration Postoperative course was uneventful. Per oral intake started on the 4th postoperative day, and the patient was discharged on the 8th postoperative day. In summary this case indicates that persistent symptoms of peptic ulcer disease associated with nutritional disturbances may be caused by gastrojejunal fistula. | Dorde M ulafi Olivera D Mateji Vladimir S Duki Miodrag D Vukevi Mirko D Kerkez | 2007 | World Journal of Gastroenterology2007，13，3： | 0 |
| 5 | Role of serotonin in development of esophageal and gastric fundal varices显示文摘AIM:To determine the effect of free serotonin concentrations in plasma on development of esophageal and gastric fundal varices. METHODS:This prospective study included 33 patients with liver cirrhosis and 24 healthy controls. Ultrasonography and measurement of serotonin concentration in plasma were carried out in both groups of subjects. The upper fiber panendoscopy was performed only in patients with liver cirrhosis. RESULTS:The mean plasma free serotonin levels were much higher in liver cirrhosis patients than in healthy controls (219.0 ± 24.2 nmol/L vs 65.4 ± 18.7 nmol/L,P < 0.0001). There was no significant correlation be-tween serotonin concentration in plasma and the size of the esophageal varices according to Spearman coefficient of correlation (rs =-0.217,P > 0.05). However,the correlation of plasma serotonin concentration and gastric fundal varices was highly significant (rs =-0.601,P < 0.01). CONCLUSION:Free serotonin is significant in pathogenesis of portal hypertension especially in development of fundal varices,indicating the clinical value of serotonergic receptor blockers in these patients. | Jelena S Rudi Dorde M ulafi Duko S Mirkovi Rada S Jei Miodrag N Krsti | 2010 | World Journal of Gastroenterology2010，16，48： | 0 |
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