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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Reusing semi-specified behavior models in systems analysis and design显示文摘 | Iris R B Dori D Shmuel K | 2009 | Software and Systems Modeling2009，8，2： | 1 |
| 3 | Modeling design patterns for semi-automatic reuse in system design显示文摘 | Galia S Iris R B Dori D | 2010 | J of Database Management2010，21，1： | 1 |
| 4 | Trichostatin A reverses skewed expression of CD154,interleukin-10 and interferon-g gene and protein expression in lupus T cells显示文摘 | Nilamadhab M Doris R B Irene M | 2001 | Proc Natl Acad Sci USA2001，98，5： | 1 |
| 5 | Ozonation of high strength segregated effluents from a woollen textile dyeing and finishing plant显示文摘 | Ahmet B Ayfer Y Doris L | 2003 | Dyes and Pigments2003，58，： | 1 |
| 6 | Mycobacterium tuberculosis-Induced CXCR4 and Chemokine Expression Leads to preferential X4 HIV-1 replication in human macrophages显示文摘 | Yoshihiko Hoshino Doris B Tes Gemma R | 2004 | Immunology2004，172，： | 1 |
| 7 | Best cases from the AFIP:congenital intracranial teratoma显示文摘 | SANDOW B A DORY C E AGUIAR M A | 2004 | Radiographics2004，24，4： | 1 |
| 8 | Full-spectrum cardiac surgery through a minimal incision:mini-sternotomy (lower half) technique显示文摘 | Doty D B Di Russo G B Dory J R | 1998 | Ann Thorac Surg1998，65，2： | 1 |
| 9 | Complications of percutaneous nephrolithotomy: risk factors and management显示文摘 | DORI B | 2006 | Urology2006，40，3： | 1 |
| 10 | Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies显示文摘 | Sohinee B Doris MC William AL | | 0，，24： | 1 |
| 11 | Specifying Model Transformations at the Metamodel Level显示文摘 | Sheena R Judson Robert B France Doris L Carver | 2003 | Proc of the Workshop in Software Model Engineering2003，，： | 1 |
| 12 | The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death in-duction显示文摘 | Michal R Doris B Jonathan D | 2009 | Mol Plant-Microbe Interact2009，22，2： | 1 |
| 13 | Free amino acid content of chicken muscle from broilers and hens显示文摘 | Julius H M Dawson L E Doris H B | 1965 | Jouenal of Food Science1965，30，3： | 1 |
| 14 | A dynamic view of sex chromosome evolution 显示文摘 | DORIS B | 2006 | Current Opinion in Genetics & Development2006，16，： | 1 |
| 15 | Operation room tool handling and miscommunication scenarios:an object-process methodol ogy conceptual model显示文摘 | Wachs JP Frenkel B Dori D | 2014 | Artif Intell Med2014，62，3： | 1 |
| 16 | Fatty acid composition of oil from damaged corn and wheat显示文摘 | Doris B | 1961 | Cereal Chemistry1961，38，： | 1 |
| 17 | Clinical Performance of All-Ceramic Inlay and Onlay Restorations in Posterior Teeth显示文摘 | Ulrike S B Ines K Doris B | 2012 | Int J Prosthodont2012，25，4： | 1 |
| 18 | Ectopic Expression of Hu- man telomerase RNA component results in increased telomerase activity and elongated telomeres in bovine blastocysts 显示文摘 | Wiebke G Wilfried B Doris H | 2012 | Biol Reprod2012，10，： | 1 |
| 19 | Influence of the wavelength in high irradiance ultraviolet laser desorption mass spectrometry of organic molecules 显示文摘 | Michael K Doris B Franz H | 1985 | Anal Chem1985，57，14： | 1 |
| 20 | Inflammatory effects of respirable quartz collected in workplaces versus standard DQ12 quartz: Particle surface correlates显示文摘 | Anna C David B Doris H | 2001 | Toxicological Science2001，63，1： | 1 |
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