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| 1 | Benign liver tumors in pediatric patients-Review with emphasis on imaging features显示文摘Benign hepatic tumors are commonly observed in adults,but rarely reported in children.The reasons for this remain speculative and the exact data concerning the incidence of these lesions are lacking.Benign hepatic tumors represent a diverse group of epithelial and mesenchymal tumors.In pediatric patients,most benign focal liver lesions are inborn and may grow like the rest of the body.Knowledge of pediatric liver diseases and their imaging appearances is essential in order to make an appropriate differential diagnosis.Selection of the appropriate imaging test is challenging,since it depends on a number of age-related factors.This paper will discuss the most frequently encountered benign liver tumors in children(infantile hepatic hemangioendothelioma,mesenchymal hamartoma,focal nodular hyperplasia,nodular regenerative hyperplasia,and hepatocellular adenoma),as well as a comparison to the current knowledge regarding such tumors in adult patients.The current emphasis is on imaging features,which are helpful not only for the initial diagnosis,but also for pre- and posttreatment evaluation and follow-up.In addition,future perspectives of contrast-enhanced ultrasound(CEUS) in pediatric patients are highlighted,with descriptions of enhancement patterns for each lesion being discussed.The role of advanced imaging tests such as CEUS and magnetic resonance imaging,which allow for non-invasive assessment of liver tumors,is of utmost importance in pediatric patients,especially when repeated imaging tests are needed and radiation exposure should be avoided. | Liliana Chiorean Xin-Wu Cui Andrea Tannapfel Doris Franke Martin Stenzel Wojciech Kosiak Dagmar Schreiber-Dietrich J?rg Jüngert Jian-Min Chang Christoph F Dietrich | 2015 | World Journal of Gastroenterology2015，21，28： | 16 |
| 2 | In Vivo Evidence of Deep Brain Stimulation-Induced Dopaminergic Modulation in Tourette’s Syndrome显示文摘 | Jens Kuhn Hildegard Janouschek Mardjan Raptis Steffen Rex Doris Lenartz Irene Neuner Felix M. Mottaghy Frank Schneider Wolfgang M. Schaefer Volker Sturm Gerhard Gründer Ingo Vernaleken | 2012 | Biological Psychiatry2012，，： | 1 |
| 3 | In Vivo Evidence of Deep Brain Stimulation-Induced Dopaminergic Modulation in Tourette’s Syndrome显示文摘 | Jens Kuhn Hildegard Janouschek Mardjan Raptis Steffen Rex Doris Lenartz Irene Neuner Felix M. Mottaghy Frank Schneider Wolfgang M. Schaefer Volker Sturm Gerhard Gründer Ingo Vernaleken | 2012 | Biological Psychiatry2012，，5： | 1 |
| 4 | Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers显示文摘Objective: Prostate secretory protein of 94 amino acids(PSP94) is a target gene of the EZH2 transcriptional repressor and is often downregulated in prostate cancer;however, its prognostic value is disputed.Methods: Immunohistochemical analysis of a tissue microarray of 12, 432 prostate cancer specimens was performed to evaluate PSP94 expression. Correlation of PSP94 expression with tumor phenotype, patient prognosis, TMPRSS2:ERG fusion status, EZH2 expression and PTEN deletion was studied.Results: PSP94 expression was increased in benign prostatic hyperplasia;however, it was downregulated in 48% and negative in42% of the 9, 881 interpretable prostate cancer specimens. The loss of PSP94 expression was inversely correlated to EZH2 expression(P < 0.0001) and largely unrelated to the ERG status, but strongly correlated with high Gleason grade, advanced tumor stage, and nodal metastasis(P <0.0001 each). The fraction of PSP94-negative cancer specimens increased from 40% in pT2 to 52%in pT3 b-pT4(P < 0.0001) and from 40% in Gleason 3+3 = 6 to 46% in Gleason 4+3 = 7 and 60% in Gleason ≥4+4 = 8(P <0.0001). Loss of PSP94 was linked to early prostate-specific antigen recurrence, but with little absolute effect(P < 0.0001).However, it provided additional prognostic impact in cancer specimens with PTEN deletion. Loss of PSP94 deteriorated prognosis of cancer patients with PTEN deletion by more than 10%(P < 0.0001). The combination of PTEN deletion and PSP94 loss provided independent prognostic information that was observed in several subgroups defined by classical and quantitative Gleason grade.Conclusions: The results of our study suggest that combined PSP94/PTEN analysis can be potentially used in the clinical prognosis of prostate cancer. | Andreas M. Luebke Ali Attarchi-Tehrani Jan Meiners Claudia Hube-Magg Dagmar S. Lang Martina Kluth Maria Christina Tsourlakis Sarah Minner Ronald Simon Guido Sauter Franziska Buscheck Frank Jacobsen Andrea Hinsch Stefan Steurer Thorsten Schlomm Hartwig Huland Markus Graefen Alexander Haese Hans Heinzer Till S. Clauditz Eike Burandt Waldemar Wilczak Doris Hoflmayer | 2019 | Cancer Biology & Medicine2019，16，2： | 1 |
| 5 | Preclinical evalua-tion of gemcitabine/paclitaxel-interactions in human bladder cancer lines 显示文摘 | Frank GP Heike L Doris S | 2003 | Anticancer Research2003，23，： | 1 |
| 6 | 怎样发挥家庭影院的最佳性能显示文摘今天家庭影院视听器材的强大功能和优异性能,在过去人们是做梦也想不到的。在过去的那个年,音响只限于两个扬声器,一部电唱机和一台放大器,现在有了让你在舒适的家中享受到更多乐趣的家庭影院。不过由于它涉及到众多的新技术,需要调整到最佳状态才能发挥其最高的性能。在这个方面有许多窍门,本文的目的就是为那些已经拥有TV、AV中心,扬声器和影碟机等影音器件,并且希望能够自己安装调试的朋友提供一些引导,起到抛砖引玉的作用。 | Frank Doris 徐学楷 | 2005 | 家庭影院技术2005，，5： | 0 |
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