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| 1 | Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes显示文摘The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal(GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between lowgrade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes. | Christina Brock Birgitte Brock Anne Grave Pedersen Asbjorn Mohr Drewes Niels Jessen Adam D Farmer | 2016 | World Journal of Diabetes2016，7，16： | 5 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | The interaction of reaction-bonded silicon carbide and Inconel 600 with a nickel-based brazing alloy显示文摘 | Mcdermid J R Pugh M D Drew R A L | 1989 | Metallurgical Transactions A1989，20，： | 1 |
| 4 | FA polydisperse model for bubbly two-phase flow around a surface ship显示文摘 | Carrica P M Drew D Bonetto F | 1999 | International Journal of Multiphase Flow1999，25，： | 1 |
| 5 | Spectrally arbitrary patterns显示文摘 | Drew J H Johnson C R Olesky D D | 2000 | Linear Algebra Appl2000，308，13： | 1 |
| 6 | 显示文摘 | Drew C Liu X Ziegler D Wang X | 2003 | Nano Letters2003，3，2： | 1 |
| 7 | Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection显示文摘 | DREW W L MINER R C BUSCH D F | 1991 | J Infect Dis1991，163，： | 1 |
| 8 | Main concepts of the ' European approach' to karst-groundwater-vulnerability assess- ment and mapping 显示文摘 | Daly D Dassargues A Drew D | 2002 | Hydrogeology Journal2002，10，： | 1 |
| 9 | Multiple paternity in a natural population of a wild tobacco fly, Bactrocera cacuminata (Diptera: Tephritidae), assessed by microsatellite DNA markers 显示文摘 | Song S D Drew R A Hughes J M | 2007 | Molecular Ecology2007，16，11： | 1 |
| 10 | Entropy minimization for shadow removal 显示文摘 | FINLAYSON G D DREW M S LU C | 2009 | International Journal of Computer Vision2009，85，1： | 1 |
| 11 | Genistein in the presence of 17beta-estradiol inhibits proliferation of ERbeta breast cancer cells显示文摘 | RAJAH T T D U N DREWS N | 2009 | Pharmacology2009，84，2： | 1 |
| 12 | A lock-docking oligo(dT) primer for 5′and 3′RACE PCR显示文摘 | Borson N D Salo W L Drewes R L | 1992 | PCR Methods Appl1992，2，： | 1 |
| 13 | Traffic Dynamics:Method for Estimating Freeway Travel Times in Real Time From Flow Measurements显示文摘 | Nam D H D R Drew | 1989 | Journal of Transportation Engineering1989，，122： | 1 |
| 14 | The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans显示文摘 | Matzinger D Degen L Drewe J | 2000 | Gut2000，46，： | 1 |
| 15 | Savoy: Absorption of methionine and 2-hydroxy-4-methylthiobutoanic acid in conventional and germ-free chickens显示文摘 | Drew M D Van Kessel A G Maer z D D | 2003 | Poultry Science2003，82，7： | 1 |
| 16 | Carbon diox- ide capture using ionic liquid 1-butyl-3-methylimidazolium acetate 显示文摘 | Shiflett M B Drew D W Cantini R A | 2010 | Energy & Fuels2010，24，10： | 1 |
| 17 | The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans 显示文摘 | MATZINGER D DEGEN L DREWE J | 2000 | Gut2000，46，5： | 1 |
| 18 | Spectrally arbitrary patterns显示文摘 | Drew J H Johnson C R Olesky D D | 2000 | Linear Algebra Appl ( S0024-3795 )2000，308，： | 1 |
| 19 | An investigation of the propagation of pressure perturbation in bubbly air/water flow显示文摘 | RUGGLES A E LAHEY R T J DREW D A | 1988 | Heat Transfer1988，1，10： | 1 |
| 20 | Deriving spectra from colors and rendering light interference 显示文摘 | Sun Y Fracehia F D Calvert T W Drew M S | 1999 | IEEE Computer Graphics and Applications1999，19，4： | 1 |
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