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| 1 | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy显示文摘The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure,myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns(mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS-STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism.Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS-STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases. | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 18 |
| 2 | High-gain integrated in-line few-mode amplifier enabling 3840-km long-haul transmission显示文摘An integrated few-mode erbium-doped fiber amplifier(FM-EDFA)with high modal gain is suitable for the in-line amplification in mode-division multiplexing transmission(MDM)systems.We first experimentally demonstrate a dual-stage integrated FM-EDFA supporting three linear polarization modes.Consisting of integrated passive components with low insertion losses,the FM-EDFA has a similar structure and performance to widely used commercial single-mode EDFAs.The averaged modal gain of 25 dB,the differential modal gain(DMG)of<1.1 dB,and noise figures of 5–7 dB are simultaneously achieved.In addition,the DMG of the 3M-EDF itself is~0.3 dB.Moreover,an MDM transmission experiment with the in-line few-mode amplification by our proposed FM-EDFA over a 3840-km few-mode fiber link for a 28-Gbaud quadrature phase-shift keying(QPSK)signal is demonstrated. | TAo Xu TIANYU GAO YANZE WANG WENHAO LI WEI LI CHENG Du ZHIQUN YANG YAPING LIU LIN ZHANG | 2022 | Photonics Research2022，10，12： | 2 |
| 3 | Acidity Evaluation of Industrially Dealuminated Y Zeolite via Methylcyclohexane Transformation显示文摘The catalytic transformation of methylcyclohexane as an accepted probe reaction to evaluate zeolitic acidity(concentration,strength,and accessibility)is employed to study the acidity and the reactivity of three commercial dealuminated Y zeolites(DAY)with different Si/Al ratios and meso/microporosities,with their properties analyzed by N_(2) adsorption/desorption,pyridine-IR,and hydroxyl-IR spectroscopy technologies.The global activity(conversion)is largely dependent on the concentration of the acid sites,and the activity of the protonic sites in terms of turnover frequency(TOF)reflects the accessibility of acid sites.The products of aromatics and isomers,and the yield of cracking products increase with the increase of concentration of strong protonic sites in zeolite micropores.Moreover,the decrease of aromatics with the reduction of the concentration of acid sites and the diffusion length within DAY zeolites are observed due to the decrease of the secondary reaction.For the same reason,it results in the increasing of C_(7)products and alkenes/alkanes ratios in the cracking products.The high i-C_(4)product selectivity is a unique reflection of the high percentage of very strong acid sites,which is characterized by the hydroxyl-IR band at 3600 cm^(-1). | Hou Kaige Qin Bo Han Junjie Du Yanze Ma Jinghong Li Ruifeng | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，3： | 0 |
| 4 | Accelerating hybrid and compact neural networks targeting perception and control domains with coarse-grained dataflow reconfiguration显示文摘Driven by continuous scaling of nanoscale semiconductor technologies,the past years have witnessed the progressive advancement of machine learning techniques and applications.Recently,dedicated machine learning accelerators,especially for neural networks,have attracted the research interests of computer architects and VLSI designers.State-of-the-art accelerators increase performance by deploying a huge amount of processing elements,however still face the issue of degraded resource utilization across hybrid and non-standard algorithmic kernels.In this work,we exploit the properties of important neural network kernels for both perception and control to propose a reconfigurable dataflow processor,which adjusts the patterns of data flowing,functionalities of processing elements and on-chip storages according to network kernels.In contrast to stateof-the-art fine-grained data flowing techniques,the proposed coarse-grained dataflow reconfiguration approach enables extensive sharing of computing and storage resources.Three hybrid networks for MobileNet,deep reinforcement learning and sequence classification are constructed and analyzed with customized instruction sets and toolchain.A test chip has been designed and fabricated under UMC 65 nm CMOS technology,with the measured power consumption of 7.51 mW under 100 MHz frequency on a die size of 1.8×1.8 mm^2. | Zheng Wang Libing Zhou Wenting Xie Weiguang Chen Jinyuan Su Wenxuan Chen Anhua Du Shanliao Li Minglan Liang Yuejin Lin Wei Zhao Yanze Wu Tianfu Sun Wenqi Fang Zhibin Yu | 2020 | Journal of Semiconductors2020，41，2： | 0 |
| 5 | Research and development of hydrocracking catalysts and technologies in China显示文摘Hydrocracking of petroleum feedstock represents a compelling route for the production of industrial clean fuels,which has triggered the continuous research and development of core technology related areas such as catalysts,reaction engineering and engineering design.This review particularly focuses on the research and development of catalysts and catalytic processes for hydrocracking of petroleum feedstock in China.Hydroprocessing technologies of China keep pace with the up-to-date progress of the world,and some of the technologies have achieved leading role in the world.It is noted that China Petroleum and Chemical Corporation has a full range of hydroprocessing technologies and provides corresponding 'tailor-made' catalysts.Through the efforts of several generations,20 categories of the catalysts including more than 60 brands have been developed,among which more than 40 brands have been successfully applied for more than 130 times.Importantly,the pivotal technical improvements including the deep drawing vacuum gas-oil (VGO) and de-asphalting oil hydrocracking technology to improve material adaptability,the high value-added hydrogenation technology to convert high aromatic diesel conversion to naphtha,the hydrocracking technology using VGO-catalytic diesel blends,the Fushun Research Institute of Petroleum and Petrochemicals' diesel to gasoline and diesel hydrocracking technologies,and the Sheer hydrocracking technology to reduce energy are reviewed. | Chong Peng Yanze Du Xiang Feng Yongkang Hu Xiangchen Fang | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 0 |
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