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| 1 | Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B显示文摘AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis B.METHODS:We included 154 consecutive patients in two treatment groups:the 'add-on' group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the 'switch/combination' group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as needed.The 'switch/combination' group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the 'add-on' group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the 'add-on' group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the 'add-on' group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment. | Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，47： | 19 |
| 2 | Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis显示文摘 | Yeon Seok Seo Sun Young Yim Jin Yong Jung Chang Ha Kim Jin Dong Kim Bora Keum Hyonggin An Hyung Joon Yim Hong Sik Lee Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2012 | Journal of Gastroenterology and Hepatology2012，，11： | 1 |
| 3 | Effect of Hypobaric Packaging on Respiration and Quality of Strawberry and Curled Lettuce显示文摘 | Duck Soon An Eunyoung Park Dong Sun Lee | 2009 | Postharvest Biology and Technology2009，52，1： | 1 |
| 4 | Wide- Spectrum Antimicrobial Packaging Materials Incorporating Nisinand Chitosaninthe Coating显示文摘 | Lee Ho Chan An Duck Soon Park Hyun Jin | 2003 | Packaging Technology and Science2003，16，3： | 1 |
| 5 | Effect of maturity and storage temperature on preservation of fresh jujube显示文摘 | Duck soon An Dong Sun lee | 1997 | Korean Journal of Food Science and Technology1997，29，4： | 1 |
| 6 | Properties of Nisin -- incorporated Polymer Coating as Antimicrobial Packaging Materials 显示文摘 | KIM Young Min AN Duck Soon PARK Hyun Jin | 2002 | Packaging Technology and Science2002，15，5： | 1 |
| 7 | Widespectrum antimicrobial packaging materials incorporating nisin and chitosan in the coating显示文摘 | Chan Ho Lee Duck Soon An Hyun Jin Park | 2003 | Packaging Technology and Science2003，16，3： | 1 |
| 8 | A coating for use as an antimicrobial and anfioxidative packaging material incorporating nisin and α-tocopherol显示文摘 | Chan Ho Lee Duck Soon An Seung Cheol Lee | 2004 | Journal of Food Engineering2004，62，4： | 1 |
| 9 | 初始气体冲洗或真空包装对韩国发酵蔬菜的影响显示文摘本文对真空或气调包装条件下,泡菜的感官与味道偏好影响进行了调查。真空状态与CO_2冲洗包可以促进CO_2的产生,有助于维持较低的压力以扩展存储过程中由于初始抽真空和水产品中CO_2的溶解度高的现象。CO_2冲洗可以提供包装产品在正常成熟状态的良好感官与凉爽宜人的味道。 | Hye Lim Lee Duck Soon An Dong Sun Lee | 2016 | 绿色包装2016，，7： | 0 |
| 10 | 农产品气调包装中作为插入式标签使用的多功能生物膜显示文摘作者研发了一款多功能的琼脂基生物膜,通过调整它的CO2和水蒸气的吸收功能使其用于新鲜农产品包装。制备该薄膜的试剂包括琼脂作为基质和水蒸气吸收剂、甘油作为塑化剂、碳酸钠(SC)和/或甘氨酸钠(SG)作为CO2吸收剂。本文对SC、SG以及SC/SG薄膜的光学性能、机械性能,以及CO2和水蒸气吸收性能进行了研究。多功能薄膜都趋于表现出机械性能差、质地硬、不透明并呈现淡黄色的颜色。这三种薄膜具有不同的CO2吸收能力和系数,SC薄膜表现出最好的吸收能力,接下来是SC/SG和SG薄膜。对吸收剂化合物的相对依赖,水蒸气吸收系数都要比CO2的吸收系数高得多。所研制的薄膜作为一个插入式标签用于香菇的气调包装(MAP),该薄膜的多功能效益也由此被展现出来。基于传质数学模型,可以定制出用于香菇的气调包装(MAP)设计。附带有SC薄膜标签的包装有能力形成产品所需的内部空气环境,从而经过5天的储存在颜色、坚固度、味道等级以及细菌生长等方面都能表现出最好的保存品质。使用含有我们多功能薄膜的定制气调包装(MAP)系统能为具有CO2敏感性的生鲜商品提供一个最佳的气调环境,保存它们的品质,并延长它们的货架寿命。 | Hong Jiang Wang Duck Soon An Jong-Whan Rhim Dong Sun Lee | 2016 | 绿色包装2016，，1： | 0 |
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