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| 1 | 症状性脑内动脉粥样硬化性血栓形成性狭窄的前瞻性研究:GESICA研究显示文摘Background: Symptomatic intracranial atherothrombotic stenoses (ICAS) are associated with high rates of cerebrovascular ischemic events. Objective: To conduct a prospective multicenter study to evaluate the natural history of ICAS and, in those patients refractory to medical treatment, the outcomes associated with intracranial angioplasty. Methods: Patients aged 18 to 80 were enrolled with symptoms attributed to a single ICAS of ≥50%. Optimal medical therapy of vascular risk factors and preventive antithrombotic therapy were at the discretion of the local investigator. Patients were eligible for intracranial angioplasty after experiencing recurrent stroke despite medical therapy. Neurologic and ultrasonographic examinations were performed at study inclusion, 3 months after enrollment, and every 6 months of follow-up thereafter, for 36 months. Results:One hundred two patients were included, with a mean age of 63.3 ±10.4 years. Intracranial artery stenoses involved the vertebral artery in 22.5%, the basilar artery in 25.5%, the middle cerebral artery in 26.5%, and the internal carotid artery in 25.5%. In 27.4%of the patients, the stenoses had clinical hemodynamic characteristics. During a mean follow-up of 23.4 months, 38.2%of the patients had a cerebrovascular event: ischemic stroke in 13.7%and TIA in 24.5%. Among patients with a hemodynamically significant stenosis, 60.7%had a recurrent stroke or TIA in the territory of the stenotic artery; this association was significant in univariate analysis.Twenty-eight patients underwent an endovascular procedure with a neurologic periprocedural complication rate of 14.2%.The overall vascular death rate was 8.8%. Conclusions: Despite medical treatment, the 2-year recurrence rate of ischemic events in the territory of the stenotic artery was 38.2%. Cardiovascular events occurred in 18.6%of patients. Clinically significant hemodynamic stenoses were associated with stroke recurrence and may help identify a high risk subset of patients. | Mazighi M. Tanasescu R. Ducrocq X. 樊慧婷(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 6 |
| 2 | Prospective study of symptomatic atherothrombotic intracranial stenoses: The GESICA Study显示文摘 | M Mazighi R Tanasescu X Ducrocq E Vicaut S Bracard E Houdart F Woimant | 2006 | Neurology2006，，8： | 2 |
| 3 | Clopidogrel 600-mg double loading dose achieves stronger platelet inhibi- tion than conventional regimens: results from the PREPAIR randomized study显示文摘 | L Allier P L Ducrocq G Pranno N | 2008 | J Am Coll Cardiol2008，51，11： | 1 |
| 4 | Diagnostic tools using a me-soscale NWP model for the early warning of convection显示文摘 | Ducrocq V Tzanos D Senesi S | 1998 | Mete-orological Applications1998，，5： | 1 |
| 5 | Lung function after lobectomy:a randomized,double-blinded trial comparing thoracic epidural ropivacaine/sufentann and intravenous morphine for patient-controlled analgesia显示文摘 | Bauer C Hentz JG Ducrocq X | 2007 | Anesth Analg2007，105，1： | 1 |
| 6 | Intracranial aneurysms:clinical value of 3D digital subtraction angiography in the therapeutic decision and endovacular treatment显示文摘 | Anxionnat R Bracard S Ducrocq X | 2001 | Radiology2001，3，11： | 1 |
| 7 | Brain death and transeranial Doppler: experience in 130 cases of brain dead patients 显示文摘 | Ducrocq X Braun M Debouverie M | 1998 | J Neurol Sci1998，160，： | 1 |
| 8 | Intracranial aneurysms: clinical value of 3D digital subtraction angiography in the therapeutic decision and endovacular treatment显示文摘 | Anxionnat R Bracard S Ducrocq X | 2001 | Radiology2001，218，3： | 1 |
| 9 | Lung function after lobectomy: A randomized, double-blinded trial comparing thoracic epidural ropivaeaine/sufentanil and intravenous morphine for patient-controlled analgesia 显示文摘 | Bauer C Hentz J G Ducrocq X | 2007 | Anesth Analg2007，105，1： | 1 |
| 10 | Intracranial aneurysms:clinical value of 3D digital subtraction angiography in the therapeutic decision and endovascular treatment显示文摘 | Anxionnat R Bracard S Ducrocq X | 2001 | Radiology2001，218，3： | 1 |
| 11 | Mechanisms of vascular hy- poresponsiveness in septic shock显示文摘 | Kimmoun A Ducrocq N Levy B | 2013 | Curr Vasc Pharmacol2013，11，2： | 1 |
| 12 | Prospective study of symptomatic atherothrombotic intracranial stenosis: the GESICA study显示文摘 | Mazighi M Tanasescu R Ducrocq X | 2006 | Neurology2006，66，8： | 1 |
| 13 | Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder 显示文摘 | Vaiva G Thomas P Ducrocq F | 2004 | Biol Psychiatry2004，55，： | 1 |
| 14 | Lung function after lobectomy:a randomized ,double-blinded trial comparing thoracic epidural ropivacaine/sufentanil and intravenous morphine for patient-controlled analgesia 显示文摘 | Bauer C Hentz JG Ducrocq X | 2007 | Anesth Analg2007，105，1： | 1 |
| 15 | Depression and sexual disorders显示文摘 | | 1999 | Encephale1999，25，： | 1 |
| 16 | Mechanisms of vascular hypore- sponsiveness in septic shock显示文摘 | Kimmoun A Ducrocq N Levy B | 2013 | Curt Vasc Pharmacol2013，11，2： | 1 |
| 17 | Post - traumatic stress post - traumatic depression and major depressive episode:Literature 显示文摘 | Ducrocq F Vaiva G Cottencin O | 2001 | En- cephale2001，27，2： | 1 |
| 18 | Intracranial aneurysms:clincial value of 3D digital subtraction angiongraphy in the therapeutic decision and endovascular显示文摘 | Anxionnat R Bracard S Ducrocq X | | 0，，03： | 1 |
| 19 | Fine mapping and haplotype structure analysis of a major flowering time quantitative trait locus on maize chromosome 10 显示文摘 | DUCROCQ S GIAUFFRET C MADUR D | 2009 | Genetics2009，183，4： | 1 |
| 20 | Surgical evacuation of acute subdural hematoma improves cerebral hemodynamics in children : a transcranial Doppler evaluation 显示文摘 | Meyer PG Ducrocq S Rackelbom T | 2005 | Childs Nerv Syst2005，21，2： | 1 |
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