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| 1 | Androgens and esophageal cancer: What do we know?显示文摘Significant disparities exist between genders for the development and progression of several gastrointestinal(GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvement of intrinsic gender-linked mechanisms is also possible for esophageal adenocarcinoma as its incidence is disproportionally high among men. However, the cause of the observed gender differences and the potential role of androgens in esophageal carcinogenesis remains unclear, even though the cancer-promoting role of androgen receptors(AR) shown in other cancers such as prostate and bladder suggests this aspect warrants exploration. Several studies have demonstrated expression of ARs in esophageal cancer. However, only one study has suggested a potential link between AR signaling and outcome- poorer prognosis. Two groups have analyzed data from cohorts with prostate cancer and one of these found a decreased incidence of esophageal squamous and adenocarcinoma after androgen deprivation therapy. However, very limited information is available about the effects of androgen and AR-initiated signaling on esophageal cancer cell growth in vitro and in vivo. Possible mechanisms for androgens/AR involvement in the regulation of esophageal cancer growth are considered, and the potential use of AR as a prognostic factor and clinical target is highlighted, although insufficient evidence is available to support clinical trials of novel therapies. As esophageal adenocarcinoma is a gender linked cancer with a large male predominance further studies are warranted to clarify the role of androgens and ARs in shaping intracellular signaling and genomic responses in esophageal cancer. | Olga A Sukocheva Bin Li Steven L Due Damian J Hussey David I Watson | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 2 | Characterization of Ba- cillus pmbiotics available for human use显示文摘 | Due le H Hong H A Barbosa T M | 2004 | Appl Environ Micro- biol2004，70，4： | 1 |
| 3 | Mutations in the P53 gene and protein expression of P53, MDM2 and P21waf1/cip1 in primary cervical carcinomas with no or low human papillomavirus load显示文摘 | Helland A Karlsen F Due EU | 1998 | Br J Cancer1998，78，1： | 1 |
| 4 | Volatile organic components migrating from plastic (HDPE, PEX and PVC) into drinking water 显示文摘 | Skjevrak I Due A Gjerstad KO | 2003 | Water Res2003，37，： | 1 |
| 5 | An improved method of surgical pathology testing for onychomycosis显示文摘 | Nazarian RM Due B Deshpande A | 2012 | J Am Acad Dermatol2012，66，4： | 1 |
| 6 | The use of bacterialspore formers as probiotics显示文摘 | Hong H A Due L H Cutting S M | 2005 | FEMS Microbiology Re-views2005，29，4： | 1 |
| 7 | A comparative study of oxycodone and morphine in a multi-modal,tissuedifferentiated experimental pain model显示文摘 | Camilla S Lola LC Due A | 2006 | Pain2006，123，1： | 1 |
| 8 | Mutations in the TP53 gene and protein expression of p53,MDM2 and p21/WAF-1 in primary cervical carcinomas with no or low human papillomavirus load显示文摘 | HELLAND A KARLSEN F DUE E U | 1998 | Br J cancer1998，78，： | 1 |
| 9 | Character- ization of Bacillus probiotics available for human use 显示文摘 | Due L H Hong H A Barbosa T M | 2004 | Appl Environ Microbiol2004，70，4： | 1 |
| 10 | WHO Collaborative Study Team on the Role of Breasffeeding on the Prevention of Infant Mortality显示文摘 | | 2000 | Lancet2000，355，9202： | 1 |
| 11 | Antioxidant evaluation of O-methylated metabolites of catechin,epicatechin and quercetin显示文摘 | Dueas M González-Manzano S González-Parmás A | 2010 | J Pharmaceut Biomed Anal2010，51，2： | 1 |
| 12 | Characterization of Bacillus Probiotics Available for Human Use显示文摘 | Due L H Huynh A Hong | 2004 | Applied and Environmental Microbiology2004，70，4： | 1 |
| 13 | Surviving extreme hypercalcaemia--a case report and review of the literature显示文摘 | Marienhagen K Due J Hanssen T A | 2005 | J Intern Meal2005，258，1： | 1 |
| 14 | Riboflavin-overproducing strains of Lactobacillus fermentum for riboflavin-enriched bread显示文摘 | Pasquale Russo Vittorio Capozzi Mattia Pia Arena Giuseppina Spadaccino María Teresa Due?as Paloma López Daniela Fiocco Giuseppe Spano | 2014 | Applied Microbiology and Biotechnology2014，，8： | 1 |
| 15 | Volatile organic components migrating from plastic pipes (HDPE, PEX and PVC) into drinking water 显示文摘 | Skjevrak I Due A Gjerstad KO | 2003 | Water Res2003，37，： | 1 |
| 16 | Volatile organic components migrating from plastic pipes (HDPE, PEX and PVC ) into drinking water显示文摘 | Skjevrak l Due A Gjerstad K O | 2003 | Water Research2003，37，8： | 1 |
| 17 | Effect of normal-fat diets,either medium or high in protein,on body weight in overweight subjects:a randomised 1-year trial显示文摘 | Due A Toubro S Skov AR | | 0，，： | 1 |
| 18 | Naturally occurring 2-substituted (1,3)-β-D-glucan producing Lactobacillus suebicus and Pediococcus parvulus strains with potential utility in the production of functional foods显示文摘 | Gaizba G I Due(n)as M T Irastorza A | 2010 | Bioresour Technol2010，101，： | 1 |
| 19 | Mortality risk prediction with an updated Acute Physiology and Chronic Health Evaluation II score in critically ill obstetric patients: a cohort study 显示文摘 | PATERNINA - Caicedo A J ROJAS - SUAREZ J A DUE AS - CASTEL C | 2015 | J Intensive Care Med2015，30，2： | 1 |
| 20 | Characterization of Bacillus Probiotics Available for Human Use 显示文摘 | Due L H Huynh A Hong | 2004 | Applied and Environ mental Microbiology2004，70，4： | 1 |
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