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| 1 | Dividing wall column structuredesign using response surface methodology 显示文摘 | van Due Long N Lee M | 2012 | Computersand Chemical Engineering2012，37，10： | 1 |
| 2 | C-reactive protein for discriminating treatment failure from slow responding pneumonia显示文摘 | Agustín Ruiz-González Miquel Falguera José Manuel Porcel Montserrat Martínez-Alonso Pamela Cabezas Paloma Geijo Ramón Boixeda Carlos Due?as Arola Armengou Josep Antoni Capdevila Regino Serrano | 2010 | European Journal of Internal Medicine2010，，6： | 1 |
| 3 | Dividing wall column structuredesign using response surface methodology 显示文摘 | Van Due Long N Lee M | 2012 | Comput-ers and Chemical Engineering2012，37，： | 1 |
| 4 | An exploration of student nurses' experiences of formative assessment 显示文摘 | Due LE Brown N | 2009 | Nume Educ Today2009，29，6： | 1 |
| 5 | Naturally occurring 2-substituted (1,3)-β-D-glucan producing Lactobacillus suebicus and Pediococcus parvulus strains with potential utility in the production of functional foods显示文摘 | Gaizba G I Due(n)as M T Irastorza A | 2010 | Bioresour Technol2010，101，： | 1 |
| 6 | HCV-specific immune responses induced by CIGB-230 in combination with IFN-α plus ribavirin显示文摘AIM:To analyze hepatitis C virus(HCV)-specific immune responses in chronically infected patients under triple therapy with interferon-α(IFN-α)plus ribavirin and CIGB-230.METHODS:CIGB-230 was administered in different schedules with respect to IFN-αplus ribavirin therapy.Paired serum and peripheral blood mononuclear cells(PBMC)samples from baseline and end of treatment were analyzed.The HCV-specific humoral response was tested by enzyme-linked immunosorbent assay,neutralizing antibodies were evaluated by cell culture HCV neutralization assays,PBMC proliferation was assayed by carboxyfluorescein succinimidyl ester staining and IFN-γsecretion was assessed by enzyme-linked immunospot.Data on virological and histological response and their association with immune variables are also provided.RESULTS:From week 12 to week 48,all groups of patients showed a significant reduction in mean leukocyte counts.Statistically significant reductions in antibody titers were frequent,but only individuals immunized with CIGB-230 as early add-on treatment sustained the core-IgG response,and the neutralizing antibody response was enhanced only in patients receiving CIGB-230.Cell-mediated immune responses also tended to decline,but significant reductions in IFN-γsecretion and total absence of core-specific lymphoproliferation were exclusive of the control group.Only CIGB-230-immunized individuals showed de novo induced lymphoproliferative responses against the structural antigens.Importantly,it was demonstrated that thequality of the CIGB-230-induced immune response depended on the number of doses and timing of administration in relation to the antiviral therapy.Specifically,the administration of 6 doses of CIGB-230 as late addon to therapy increased the neutralizing antibody activity and the de novo core-specific IFN-γsecretion,both of which were associated with the sustained virological response.CONCLUSION:CIGB-230,combined with IFN-α-based therapy,modifies the immune response in chronic patients.The study provides evidence for the design of more effective therapeutic vaccine interventions against HCV. | Yalena Amador-Caizares Gillian Martínez-Donato Liz lvarez-Lajonchere Claudia Vasallo Mariacarla Dausá Daylen Aguilar-Noriega Carmen Valenzuela Ivette Raíces Jean Dubuisson Czeslaw Wychowski Zurina Cinza-Estévez Marlén Castellanos Magdalys Núez Anny Armas Yaimé González Ismariley Revé Ivis Guerra ngel Pérez Aguiar Santiago Dueas-Carrera | 2014 | World Journal of Gastroenterology2014，20，1： | 1 |
| 7 | gyrB As a Phyloge-netic Discriminator for Members of the Bacillus anthrucis-i er^-us-Lhuringiensis Group显示文摘 | La Due M T Satom I M Agata N | 2004 | Journal Microbiological Methods2004，563，： | 1 |
| 8 | Nu eleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full- length cDNA显示文摘 | N Ruggli Jon-- Due Tratschin Christian Mittelholzer | 1996 | J Virol1996，70，： | 1 |
| 9 | Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease显示文摘 | José L. Pérez-Castrillón Gemma Vega Laura Abad Alberto Sanz José Chaves Gonzalo Hernandez Antonio Due?as | 2007 | The American Journal of Cardiology2007，，7： | 1 |
| 10 | Pigment encapsu-lation by emulsion polymerization using macro-RAFTcopolymers显示文摘 | Due N Hollie S Z Jason M F | 2008 | Langmuir2008，24，5： | 1 |
| 11 | Colour implications of self-association processes of wine anthocyanins显示文摘 | GONZ(A)LEZ-MANZANO S SANTOS-BUELGA C DUE(N)AS M | | 0，，3： | 1 |
| 12 | Bacterial spores asvaccine vehicles 显示文摘 | Due L H Hong H A Fairweather N | 2003 | Infection and immunity2003，71，5： | 1 |
| 13 | Numerical modeling of bed deformation in laboratory channels显示文摘 | Due M B Wenka T N Rodi W | 2004 | Journal of Hydraulic Engineering2004，130，9： | 1 |
| 14 | Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling显示文摘 | Due M R Piekarz A D Wilson N | 2012 | J Neuroinflammation2012，9，： | 1 |
| 15 | An Approach to Design Interface Topologies Across Interdependent Urban Infrastructure Systems显示文摘 | Ouyang M Due(n)as-Osorio L | | 0，，11： | 1 |
| 16 | Pathologic response and toxicity assessment of chemoradiotherapy with cisplatin versus cisplatin plus gemcitabine in cervical cancer:a randomized Phase Ⅱ study显示文摘 | Due(n)as-González A Cetina-Perez L Lopez-Graniel C | 2005 | Int J Radiat Oncol Biol Phys2005，61，3： | 1 |
| 17 | The whats,whys,hows and whos of content-based instruction in second/foreign language education显示文摘 | Due (n) as M | | 0，，01： | 1 |
| 18 | Heterotopic cesarean scar pregnancy associated with a levonorgestrel-releasing intrauterine device显示文摘 | Due(n)as-Garcia OF Young C | | 0，，： | 1 |
| 19 | A truncated HCV core protein elicits a potent immune response with a strong participation of cellular immunity components in mice显示文摘 | Alvarez-Obregón J C Dueas-Carrera S Valenzuela C Grillo J M | 2001 | Vaccine2001，19，2829： | 1 |
| 20 | gyrB as a phylogenetic discriminator for members of the Bacillus anthracis-cereus-thuringiensis group显示文摘 | La Due M T’ Satomi M Agata N | 2004 | Journalof Microbiological Methods2004，56，3： | 1 |
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