| 2 | Fibrinogen-thrombin collagen patch reinforcement of highrisk colonic anastomoses in rats显示文摘AIM To evaluate the effectiveness of human fibrinogenthrombin collagen patch (TachoSil?) in the reinforcement of high-risk colon anastomoses. METHODS A quasi-experimental study was conducted in Wistar rats (n = 56) that all underwent high-risk anastomoses (anastomosis with only two sutures) after colectomies.The rats were divided into two randomized groups:Control group (24 rats) and treatment group (24 rats).In the treatment group, high-risk anastomosis was reinforced with TachoSil? (a piece of TachoSil? was applied over this high-risk anastomosis, covering the gap). Leak incidence, overall survival, intra-abdominal adhesions, and histologic healing of anastomoses were analyzed. Survivors were divided into two subgroups and euthanized at 15 and 30 d after intervention in order to analyze the adhesions and histologic changes.RESULTS Overall survival was 71.4% and 57.14% in the TachoSil? group and control group, respectively (P = 0.29); four rats died from other causes and six rats in the treatment group and 10 in the control group experienced colonic leakage (P > 0.05). The intra-abdominal adhesion score was similar in both groups, with no differences between subgroups. We found non-significant differences in the healing process according to the histologic score used in both groups (P = 0.066). CONCLUSION In our study, the use of TachoSil? was associated with a non-statistically significant reduction in the rate of leakage in high-risk anastomoses. TachoSil? has been shown to be a safe product because it does not affect the histologic healing process or increase intra-abdominal adhesions. | Juan Manuel Suárez-Grau Carlos Bernardos García Carmen Cepeda Franco Cristina Mendez García Salud García Ruiz Fernando Docobo Durantez Salvador Morales-Conde Javier Padillo Ruiz | 2016 | World Journal of Gastrointestinal Surgery2016，8，9： | 1 |
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