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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Genomic mapping in Pinus pinaster( matitime pine) using RAPD and protein markers 显示文摘 | Plomion C BahIman N Durel C E | 1995 | Heredity1995，74，： | 1 |
| 3 | Genomic mapping in maritime pine (Pinus pinaster) using RAPD markers显示文摘 | Plomion C Bahuman N Durel C E | 1995 | Heredity1995，74，： | 1 |
| 4 | Genomic mapping in Pinus pinaster (matitime pine) using RAPD and protein markers显示文摘 | PLOMION C N BAHRMAN C E DUREL O'MALLEY D M | 1995 | Heredity1995，74，： | 1 |
| 5 | Genomic mapping in P-i- nus pinaster ( maritime pine) using RAPD and protein markers 显示文摘 | Plomion C Bahrman N Durel C E | 1995 | Heredity1995，74，8： | 1 |
| 6 | Models of membrane-bound Alzheimer's Abeta peptide assemblies 显示文摘 | Shafrir Y Durell S Arispe N | 2010 | Proteins2010，78，16： | 1 |
| 7 | Transient left ventricular apical ballooning or the tako-teubo syndrome显示文摘 | Lipiecki J Durel N Decalf V | 2005 | Arch Mal Coeur Vaiss2005，98，： | 1 |
| 8 | Models of membrane-bound Alzheimer' s Abeta peptide assemblies显示文摘 | Shafrir Y Durell S Arispe N | 2010 | Proteins2010，78，： | 1 |
| 9 | IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling显示文摘Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the development of Th2-driven diseases remains unknown. Using a model of house dust mite (HDM)-induced Th2 cell differentiation and allergic airway inflammation, we showed that IL-6 signaling in allergen-specific T cells was required to prevent Th2 cell differentiation and the subsequent IgE response and allergic inflammation. Th2 cell lineage commitment required strong sustained IL-2 signaling. We found that IL-6 turned off IL-2 signaling during early T-cell activation and thus inhibited Th2 priming. Mechanistically, IL-6-driven inhibition of IL-2 signaling in responding T cells was mediated by upregulation of Suppressor Of Cytokine Signaling 3 (SOCS3). This mechanism could be mimicked by pharmacological Janus Kinase-1 (JAK1) inhibition. Collectively, our results identify an unrecognized mechanism that prevents the development of unwanted Th2 cell responses and associated diseases and outline potential preventive interventions. | Holly Bachus Erin McLaughlin Crystal Lewis Amber M.Papillion Etty N.Benveniste Dave Durell Hill Alexander F.Rosenberg AndréBallesteros-Tato Beatriz León | 2023 | Cellular & Molecular Immunology2023，20，6： | 0 |
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