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| 1 | Preclinical models of idiosyncratic drug-induced liver injury(iDILI):Moving towards prediction显示文摘Idiosyncratic drug-induced liver injury(iDILI) encompasses the unexpected harms that prescription and non-prescription drugs,herbal and dietary supplements can cause to the liver.iDILI remains a major public health problem and a major cause of drug attrition.Given the lack of biomarkers for iDILI prediction,diagnosis and prognosis,searching new models to predict and study mechanisms of iDILI is necessary.One of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant iDILI.Thus,major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI patients.However,there are many gaps for explaining all the complexity of iDILI susceptibility and mechanisms.Therefore,there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug development.Here,the current experimental models and the future directions in iDILI modelling are thoroughly discussed,focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI models.We also comment about in silico approaches and the increasing relevance of patient-derived cellular models. | Antonio Segovia-Zafra Daniel E.Di Zeo-Sanchez Carlos Lopez-Gomez Zeus Perez-Valdes Eduardo Garcıa-Fuentes Raul J.Andrade M.Isabel Lucena Marina Villanueva-Paz | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 3 |
| 2 | Poly(ethylene terephthalate) foams: Correlation between the polymer properties and the foaming process显示文摘 | L.Sorrentino E.Di Maio S.Iannace | 2009 | J. Appl. Polym. Sci2009，，： | 1 |
| 3 | The long‐term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis显示文摘 | B.Annibale E.Di Giulio P.Caruana E.Lahner G.Capurso C.Bordi G.Delle Fave | 2002 | Alimentary Pharmacology & Therapeutics2002，，10： | 1 |
| 4 | 查看详情显示文摘 | G.Das L.Ferraioli P.Bettotti F.De Angelis G.Mariotto L.Pavesi E.Di Fabrizio G.D.Soraru | | 0，，： | 1 |
| 5 | Analytical and technological aspects of amylose inclusion complexes for potential applications in functional foods显示文摘The linear component of starch,amylose,has the ability to interact with hydrophobic molecules forming inclusion complexes(ICs).These structures have gained a particular interest for potential food applications,either as dietary fiber or as delivery systems of bioactive compounds.In the second case,the complexation of sensitive molecules is directed to protect them from processing,storage and stomach conditions and to guarantee a sustained release in the gastrointestinal tract.The present review covers the analytical and technological aspects of inclusion complexes,with focus on their potential application in the development of functional foods.It was addressed by first explaining the methodologies used for the analytical assessment of their structural,thermal,and functional properties,followed by the study of the functionality of ICs as carrier agents of different bioactive compounds and food ingredients,including alpha-lipoic acid,α-linolenic and linoleic fatty acids,conjugated linoleic acid,ascorbyl palmitate,phenolic compounds,and flavors.It also covers the application of ICs in food products and the analysis of the potential industrial scalability of the formation process.The analytical methodologies allowed a complete characterization of the ICs.These structures have shown suitable functional properties as delivery systems of the bioactive compounds and flavors covered in this review.The incorporation of ICs in food has led to the development of products with improved nutritional and/or functional value.The successful formation of complexes using methods suitable for an industrial scale represents promising preliminary results to achieve the scalability of the ICs production in the near future. | Andrea E.Di Marco Vanesa Y.Ixtaina Mabel C.Tomás | 2022 | Food Bioscience2022，47，3： | 0 |
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