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80篇 您的检索式:作者名="EIB"
    题名 作者 年代 出处 被引量
1Classifier chains for multi-label classification显示文摘Jesse Read Bernhard Pfahringer Geoff Holmes Eibe Frank 2011Machine Learning2011,,3:2
2The WEKA data mining software显示文摘Mark Hall Eibe Frank Geoffrey Holmes Bernhard Pfahringer Peter Reutemann Ian H. Witten 2009ACM SIGKDD Explorations Newsletter2009,,1:2
3Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis显示文摘α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1)(hereafter denoted as SVBP-VASH1) that catalyzes the detyrosination of a peptide derived from C-terminus of α-tubulin. We further solved the crystal structures of the SVBP-VASH1 heterodimer alone and in complex with either an inhibitor or a mutant substrate peptide. Our structural research, complemented by biochemical and mutagenesis experiments, resulted in identification of the key residues for VASH1 binding to SVBP and α-tubulin substrate. Our in vivo experiments reveal that MT detyrosination in general, as well as the interactions between SVBP, VASH1, and α-tubulin, are critical for spindle function and accurate chromosome segregation during mitosis. Furthermore, we found that the phenotypes caused by the depletion of vasohibins were largely rescued upon co-depletion of kinesin13/MCAK, suggesting the coordination between the MT depolymerase and MT detyrosination during mitosis. Thus our work not only provides structural insights into the molecular mechanism of α-tubulin detyrosination catalyzed by SVBP-bound vasohibins, but also uncovers the key role of vasohibins-mediated MT detyrosination in spindle morphology and chromosome segregation during mitosis.Shanhui Liao Girish Rajendraprasad Na Wang Susana Eibes Jun Gao Huijuan Yu Gao Wu Xiaoming Tu Hongda Huang Marin Barisic Chao Xu 2019Cell Research2019,29,7:2
4Recongnition of Platelet-associated fibrinogen-by Polyclonal antibodies:Correlation with Platelet aggregation显示文摘Peerschke EIB 1992Blood1992,79,:1
5Inflatable crown rolls-characteristics, design and applications显示文摘Eibe W W 1984Iron and Steel Engineer1984,61,9:1
6Performance Measurement in MunicipalGovernment: Assessing the State of the Practice显示文摘Poister T H Stl*eib G 1999Public Ad-ministration Review1999,59,4:1
7Recognition of platelet-associated fibrinogen by polyclonal antibodies:correlation with platelet aggregation显示文摘Peerschke EIB 1992Blood1992,79,:1
8Maximizing the ex vivo expansion of human mesenchymal stem cel s using a microcarrier-based stirred culture system显示文摘Eibes G dos Santos F Andrade PZ 0,,04:1
9Ex vivo expansion of human mesenchymal stem cel s on microcarriers显示文摘dos Santos F Andrade PZ Eibes G 0,,:1
10A DNA vector based RNAi technology to supperss gene expression in mammalian cells 显示文摘Sui G Soohoo C Affar EIB 2002Proc Natl Acad Sci USA2002,99,33:1
11Evaluation of bactec mycosis IC/F and Plus Aerobic/F blood culture bottles for detection of Candidain the presence of antifungal agents显示文摘Kock R Eibing LC Boschin MG 2013J Clin Microbiol2013,51,11:1
12A DNA vector-based RNAi technology to suppress gene expression in mammalian cells显示文摘Sui G Soohoo C Affar EIB 2002Proc Natl Acad Sci USA2002,99,8:1
13Recongnition of platelet-associated fibrinogen dy ployclonal antibodies:correlation with platelet aggregation显示文摘 1992Bloob1992,79,:1
14Recongnition of latelet-associated febrenogaen by pdyclonal antibodies:Corrsction with platelet aggregation显示文摘Peerchlele EIB 0,,:1
15Recognition of platelet-asseciated fibrinogen by ploy-clonal antibodies: correlation with platelet aggregation 显示文摘Peerschke EIB 1992Blood1992,79,1:1
16Immobilisation of laccase on Eupergit supports and its application for the removal of endocrine disrupting chemicals in a packed-bed reactor显示文摘Lloret L Hollmann F Eibes G 2012Biodegradation2012,23,3:1
17Relation between cerebral perfusion pressure and arterial pressure in brain oedema显示文摘 Waechter RV Eibs G 1972Lancet1972,1,:1
18Recongnition of platelet-associated fibrinogenby polyclonal antibodies:Correlation with platelet aggregation显示文摘Peerschke EIB 1992Blood1992,79,:1
19A DNA vector based RNAitechnology to supress gene expression in mammalian cells 显示文摘Sui G Soohoo C Affar EIB 2002ProcNatl Acad Sci2002,99,8:1
20Knowledge - enabled Customer Relationship Management: Integrating Customer Relation- ship and Knowledge Management Concepts 显示文摘Gebert H C eib M Kolbe L Brenner W 2003Journal of Knowl- edge Management2003,7,5:1
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