5篇
您的检索式：作者名="ELEFTHERIA P"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | NOD2/CARD15 , ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease显示文摘AIM: To assess whether the polymorphisms of NOD2/ CARD15 , autophagy-related 16-like 1 (ATG16L1 ), and interleukin-23 receptor (IL23R ) genes play a more critical role in the susceptibility of childhood-onset than in adult-onset Crohn’s disease (CD). METHODS: Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 ; rs2241880 A/G of ATG16L1 , and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals. Analysis of polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 genotyping was performed by allele specific polymerase chain reaction (PCR) or by PCR-restriction fragment length polymor-phism analysis. The polymorphisms rs2241880 A/G of the ATG16L1 , and rs11209026 (R381Q) of the IL23R gene in the children’s cohort were genotyped by PCR and melting curve analysis whereas adult group genotyping was performed using the Affymetrix Genome-Wide Human SNP Array 5.0 (500K). RESULTS: The 3020insC allele in NOD2/CARD15 was significantly higher in childhood than in adult-onset CD (P = 0.0067). Association with at least 1 NOD2/CARD15 variant was specific for ileal disease (with or without co- lonic involvement). Even if the frequency of G allele of the rs2241880 ATG16L1 polymorphism was increased in both paediatric and adult CD patients compared to con- trols (P = 0.017 and P = 0.001, respectively), no difference was observed between the childhood and the adult cohort. The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort. The presence of the rs2241880 ATG16L1 and rs11209026 IL23R polymorphisms did not influence disease phenotype. CONCLUSION: Polymorphism 3020insC in NOD2/ CARD15 occurs statistically significantly more often in patients with childhood-onset CD than in patients with adult-onset CD. The ATG16L1 and IL23R variants are associated with susceptibility to CD, but not earlyonset disease. | Maria Gazouli Ioanna Pachoula Ioanna Panayotou Gerassimos Mantzaris George Chrousos Nicholas P Anagnou Eleftheria Roma-Giannikou | 2010 | World Journal of Gastroenterology2010，16，14： | 7 |
| 2 | Adequate margins for Random setup uncertainties in head-an-neck IMRT显示文摘 | Eleftheria A Arjan B Cornelis P J | 2005 | Int J Ra- diat Oncol Biol Phys2005，61，3： | 1 |
| 3 | Op- timal robot speed trajectory by minimization of the actuator motor electromechanical losses 显示文摘 | ELEFTHERIA S S GEORGE S S ANASTASIOS D P | 2002 | Journal of Intelligent and Robotic Systems2002，33，： | 1 |
| 4 | Unplanned ex- tubation in critically ill adults:clinical revie显示文摘 | Panagiotis K Diamanto A Eleftheria P | 2012 | British Association of Critical Care Nurses2012，18，3： | 1 |
| 5 | AlexandridisA simple electric circuit model for proton exchange membranefuel cells显示文摘 | STAVROS L ELEFTHERIA P ANTONIO T | 2009 | Journal of Power Sources2009，190，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员