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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Bleeding with the artificial heart: Gastrointestinal hemorrhage in CF-LVAD patients显示文摘Continuous-flow left ventricular assist devices(CF-LVADs)have significantly improved outcomes for patients with end-stage heart failure when used as a bridge to cardiac transplantation or,more recently,as destination therapy.However,its implantations carries a risk of complications including infection,device malfunction,arrhythmias,right ventricular failure,thromboembolic disease,postoperative and nonsurgical bleeding.A significant number of left ventricular assist devices(LVAD)recipients may experience recurrent gastrointestinal hemorrhage,mainly due to combination of antiplatelet and vitamin K antagonist therapy,activation of fibrinolytic pathway,acquired von Willebrand factor deficiency,and tendency to develop small intestinal angiodysplasias due to increased rotary speed of the pump.Gastrointestinal bleeding in LVAD patients remains a source of increased morbidity including the need for blood transfusions,extended hospital stays,multiple readmissions,and overall mortality.Management of gastrointestinal bleeding in LVAD patients involves multidisciplinary approach in stabilizing the patients,addressing risk factors and performing structured endoluminal evaluation with focus on upper gastrointestinal tract including jejunum to find and eradicate culprit lesion.Medical and procedural intervention is largely successful and universal bleeding cessation occurs in transplanted patients. | Grigoriy E Gurvits Elena Fradkov | 2017 | World Journal of Gastroenterology2017，23，22： | 4 |
| 3 | A simple method for cryopreservation of Ginkgo biloba callus显示文摘 | Elena V P Lee E J Wu C H | 2009 | Plant Cell Tissue and Organ Culture2009，97，3： | 1 |
| 4 | Stress henodynamic and inhaled and intravenous anesthetic laparoscopic chloecystectomy显示文摘 | Grazida E Elena G Gobbo immunological techniques for Esp Anestesid responses to video-assisted M | 2005 | Rev Reanim2005，52，4： | 1 |
| 5 | Determination of volatile aldehydes forevaluafionof in vitro antioxidant activity 显示文摘 | Elena E Stashenko M A Puertas J R | 2002 | Anal Bioanal Chem2002，373，： | 1 |
| 6 | Perforin gene mutation in patients with acquired aplastic anemia显示文摘 | Elena E | 2007 | Blood2007，109，： | 1 |
| 7 | Effect of Single-Walled Carbon Nanotube Purity on the Thermal Conductivity of Carbon Nanotube Based Composites 显示文摘 | Yu Aiping ltkis Mikhall E Bekyarova Elena | 2006 | Applied Physics Letters2006，89，13： | 1 |
| 8 | Summer distribution, abundance and population structure of Illex argentinus on the Argentine shelf in relation to environmental features显示文摘 | BRUNETYI N E ELENA B ROSS1 G R | 1998 | South Africa Journal of Marine Science1998，20，1： | 1 |
| 9 | Development of three real-time PCR assays to detect peanut allergen residue in processed food products显示文摘 | Elena Scaravelli Marcel Brohée Rosangela Marchelli Arjon J. Hengel | 2008 | European Food Research and Technology2008，，3： | 1 |
| 10 | Elec- tronic properties of single-walled carbon nanotube networks 显示文摘 | Elena Bekyarova Mikhail E Itkis Nelson Cabrera | 2005 | American Chemical Society2005，127，16： | 1 |
| 11 | Evolution experiments with microorgan- isms:the dynamics and genetic bases of adaptation 显示文摘 | Elena S F Lenski R E | 2003 | Nat Rev Genet2003，4，： | 1 |
| 12 | Cooperation among strangers with limited information about reputation 显示文摘 | GARY E BOLTON ELENA K AXEL O | 2005 | Journal of Public Economics2005，89，1： | 1 |
| 13 | Martfnez SPME determination of volatile aldehydes for evaluation of in - vitro antioxidant activity 显示文摘 | Elena E Stashenko Miguel A Puertas Jairo R | 2002 | Anal Bioanal Chem2002，373，： | 1 |
| 14 | Vegetative compatibility groups within Vertic il lium dahlliae isolates from different hosts in Greece显示文摘 | Elena K Paplomatas E J | | Plant Pathology0，47，： | 1 |
| 15 | Nitrogen Absorption and Respiration in White andBrown Peach Roots显示文摘 | Elena Baldi Christina E Wells Bruno Marangoni | 2010 | Journal of plant Nutrition2010，33，3： | 1 |
| 16 | First complete seasonal variation study of the 3D optical turbulence above San Pedro martir observatory显示文摘 | ELENA M SEBASTIAN E | 2004 | Proc of SPIE2004，5490，： | 1 |
| 17 | Quality of Pink Lady apple 显示文摘 | de ELENA C H BIASI B MITCHA E | 2005 | Washangton Tree Fruit Postharvest Conference2005，，： | 1 |
| 18 | Chaotic attractors,chaotic saddles and fractal basin boundaries:goodwin nonlinear accelerator model reconsidered显示文摘 | Lorenz H W Nusse H Elena E | 2002 | Chaos Solitons and Fractals2002，13，5： | 1 |
| 19 | The combination of fructooligosaccharides and resistant starch shows prebiotic additive effects in rats显示文摘 | Maria Elena Rodríguez-Cabezas Desirée Camuesco Belén Arribas Natividad Garrido-Mesa Mònica Comalada Elvira Bailón Margarita Cueto-Sola Pilar Utrilla Eduardo Guerra-Hernández Carlos Pérez-Roca Julio Gálvez Antonio Zarzuelo | 2010 | Clinical Nutrition2010，，6： | 1 |
| 20 | Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp, in response to the deleterious changes induced by H2O2 显示文摘 | Elena G B Ana I D Maria E C | 2013 | Nat Prod2013，76，5： | 1 |
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