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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | BjussuSP-I:a new thrombin-like enzyme isolated from Bothropsjararacussu snake ven- om 显示文摘 | Sant' Ana C D Tic|i F K Oliveira L L | 2008 | Comp Biochem Physiol A Mol Integr Physiol2008，151，3： | 1 |
| 3 | A spare parts model with cold-standby redundancy on system level 显示文摘 | Karin S S D Nicole P E Ana I B | 2011 | Computers : Operations Research2011，38，7： | 1 |
| 4 | Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp, in response to the deleterious changes induced by H2O2 显示文摘 | Elena G B Ana I D Maria E C | 2013 | Nat Prod2013，76，5： | 1 |
| 5 | Phylogeography and population genetic structure of the Talas tuco-tuco (Ctenomys talarum): integrating demographic and habitat histories显示文摘 | Mora Mat?as S Cutrera Ana P Lessa Enrique P Vassallo Aldo I D’Anatro Alejandro Mapelli Fernando J | 2013 | Journal of Mammalogy2013，，2： | 1 |
| 6 | Studies on the interaction of emeraldine base polyaniline with Cu(Ⅱ), Fe(Ⅲ), and Zn(Ⅱ) ions in solutions and films显示文摘 | Celly M S I Ana M D C F Vera R L C | 2007 | Macromolecules2007，40，： | 1 |
| 7 | Disappearance of azoxystrobin,pyrimethanil, cyprodinil, and fludioxonil on tomatoes in a greenhouse显示文摘 | VINCENZO L G ALBERTO A ANA A D R I | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 8 | A discrete simulation anal- ysis of a logistics supply system 显示文摘 | ANA D I REINALDO M | 2006 | Logistics and Transportation Review2006，42，3： | 1 |
| 9 | Lignin aerobic oxidation promoted by molybdovanadophosphate polyanion ^8- 显示文摘 | Evtuguin D V Daniel Ana I D Armando J D | 2000 | Journal of Molecular Catalysis A: Chemical2000，154，1： | 1 |
| 10 | Porcine parvovirus:DNASequence and Genome Organization显示文摘 | Ana I R Juan J M Esmeralda D A | 1989 | Gen Virol1989，70，： | 1 |
| 11 | Invasion biology of the Chinese mitten crab Eriochier sinensis:a brief review显示文摘 | Ana I D Charles E E | | 0，，02： | 1 |
| 12 | What is the optimal level of vitamin D in non-dialysis chronic kidney disease population?显示文摘AIM To evaluate thresholds for serum 25(OH)D concentrations in relation to death, kidney progression and hospitalization in non-dialysis chronic kidney disease(CKD) population.METHODS Four hundred and seventy non-dialysis 3-5 stage CKD patients participating in OSERCE-2 study, a prospective, multicenter, cohort study, were prospectively evaluated and categorized into 3 groups according to 25(OH)D levels at enrollment(less than 20 ng/mL, between 20 and 29 ng/mL, and at or above 30 ng/mL), considering 25(OH)D between 20 and 29 ng/mL as reference group. Association between 25(OH)D levels and death(primary outcome), and time to first hospitalization and renal progression(secondary outcomes) over a 3-year followup, were assessed by Kaplan-Meier survival curves and Cox-proportional hazard models. To identify 25(OH)D levels at highest risk for outcomes, receiver operating characteristic(ROC) curves were performed.RESULTS Over 29 ± 12 mo of follow-up, 46(10%) patients dead, 156(33%) showed kidney progression, and 126(27%) were hospitalized. After multivariate adjustment, 25(OH)D < 20 ng/mL was an independent predictor of all-cause mortality(HR = 2.33; 95%CI: 1.10-4.91; P = 0.027) and kidney progression(HR = 2.46; 95%CI: 1.63-3.71; P < 0.001), whereas the group with 25(OH)D at or above 30 ng/mL did not have a different hazard for outcomes from the reference group. Hospitalization outcomes were predicted by 25(OH) levels(HR = 0.98; 95%CI: 0.96-1.00; P = 0.027) in the unadjusted Cox proportional hazards model, but not after multivariate adjusting. ROC curves identified 25(OH)D levels at highest risk for death, kidney progression, and hospitalization, at 17.4 ng/mL [area under the curve(AUC) = 0.60; 95%CI: 0.685-0.69; P = 0.027], 18.6 ng/mL(AUC = 0.65; 95%CI: 0.60-0.71; P < 0.001), and 19.0 ng/m L(AUC = 0.56; 95%CI: 0.50-0.62; P = 0.048), respectively.CONCLUSION25(OH)D < 20 ng/mL was an independent predictor of death and progression in patients with stage 3-5 CKD, with no additional benefits when patients reached the levels at or above 30 ng/m L suggested as optimal by CKD guidelines. | Pablo Molina JoséL Górriz Mariola D Molina Sandra Beltrán Belén Vizcaíno Verónica Escudero Julia Kanter Ana Iávila Jordi Bover Elvira Fernández Javier Nieto Secundino Cigarrán Enrique Gruss Gema Fernández-Juárez Alberto Martínez-Castelao Juan F Navarro-González Ramón Romero Luis M Pallardó | 2016 | World Journal of Nephrology2016，5，5： | 1 |
| 13 | Prognostic factors and prevention of radioembolization‐induced liver disease显示文摘 | Belen Gil‐Alzugaray Ana Chopitea Mercedes I?arrairaegui Jose I. Bilbao Macarena Rodriguez‐Fraile Javier Rodriguez Alberto Benito Inés Dominguez Delia D’Avola Jose I. Herrero Jorge Quiroga Jesus Prieto Bruno Sangro | 2013 | Hepatology2013，，： | 1 |
| 14 | Two new actions of topiranate:inhibition of depolarizing GABAA-mediated responses and activation of a potassium conductance显示文摘 | Ana I H Nuria D O Jose R G | 2002 | Neuropharmacology2002，4，： | 1 |
| 15 | 2009,Sexual size dimorphism in the evolutionary context of faeulatative paedomorphosis:insights from Euro-pean newts显示文摘 | Mathieu D Ana I Georg D | 2009 | Evolutionary Biology2009，9，278： | 1 |
| 16 | The FOXO1 -miR27 Tandem Regulates Myometrial Invasion in Endometrioid Endometrial Adenocarcinoma显示文摘 | Ana Mozos Lluis Catasús Emanuela D’Angelo Elena Serrano I?igo Espinosa Irene Ferrer Cristina Pons Jaime Prat | 2013 | Human Pathology2013，，： | 1 |
| 17 | Student Learning Styles Adaptation Method Based on Teaching Strategies and Electronic Media显示文摘 | Ana Lidia Franzoni Sa(i)d Assar | | 0，，04： | 1 |
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