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| 1 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 2 | 过度表达的内皮素1通过改变氧化应激加重糖尿病诱导的内皮功能障碍显示文摘内皮素1表达增加引起内皮功能障碍和氧化应激。通常糖尿病患者体内的血浆内皮素1水平增加。鉴于糖尿病患者的内皮功能障碍常先于血管并发症,研究者假设在血管内皮细胞中,内皮素1的过度表达会加莺糖尿病引起的血管内皮功能障碍。 | Idris-Khodja N Ouerd S Mian MO Gornitsky J Barhoumi T Paradis P Schiffrin EL 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 2 |
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| 4 | Local excision of rectal cancer review of literature 显示文摘 | Nastro P Beral D Hartley J el al | 2005 | Dig Surg2005，22，12： | 1 |
| 5 | Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models显示文摘 | Motamedi GK Salazar P Smith EL | 2006 | Epilepsy Research2006，70，： | 1 |
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| 9 | Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder显示文摘 | Wignall EL Dickson JM Vaughan P | 2004 | Biol Psychiatry2004，56，11： | 1 |
| 10 | Chemotherapy plus radiotherapy compared with radiotherapy alone in the treatment of locally advanced,unresectable,non-small cell lung cancer:a Meta-analysis显示文摘 | Robert S Pritchard EL Stephen P | 2009 | Annal Int Med2009，，： | 1 |
| 11 | Characterization of the bovine pregnancy-associated glycoprotcin gone family-analysisof gene sequences, regulatory regions within the promoter and expression of selected genes 显示文摘 | Telugu B P Walker A M Green J A et el | 2009 | BMC Genomics2009，10，： | 1 |
| 12 | Two Greek Siblings with Sepiapterin Reductase Deficiency 显示文摘 | VERBEEK M M WILLEMSEN M A A P WEVERS R A eL al | 2008 | Molecular Genetics and Metabolism2008，94，4： | 1 |
| 13 | The sentinel fat pads: the relationship of the ROOF and SOOF to the tem- poral nerve in facial rejuvenation显示文摘 | SINGH D P FORTE A J APOSTOLII)ES J G el al | 2011 | Aesthet Surg J2011，31，1： | 1 |
| 14 | A second gene for cenllean cataracls maps to Ihe hera crysiallin region on chromosome 22显示文摘 | Kramer P Yount J Mitchell T et el | 1996 | Genomics1996，35，3： | 1 |
| 15 | Chemokine-binding viral protein MT7 prevents chronic rejection in rat renal allografts显示文摘 | Bedard EL Kim P Jiang J | 2003 | Transplantation2003，76，1： | 1 |
| 16 | Regeneration of the myoeardiurn: a new role in treatment of ischemic heart disease显示文摘 | Hagege AA Vilquin JT Bruneval P el al | 2001 | Hypertension2001，38，： | 1 |
| 17 | Development of a unique phantom to assess the geometric accuracy of magnetic resonance imaging for stereotactic localization显示文摘 | ORTH RC SINHA P MADSEN EL | 1999 | Neurosurgery1999，45，6： | 1 |
| 18 | Intravenous nesiritide a nat riuretic peptide in the treament of decompensated congestive heart failure显示文摘 | Colucci S El U Horton P | 2000 | New Engl J Med2000，343，4： | 1 |
| 19 | Tracking fish by airborne radar - fishermen could be the winner显示文摘 | GRIFFITHS F B LYNE V D HARRIS G P et el | 1989 | Australian Fisheries1989，48，： | 1 |
| 20 | Treatment of brain metastases from melanoma显示文摘 | MCWILLIAMS R R BROWN P D BUCKNER J C et el | 2003 | Mayo Clin Proc2003，78，12： | 1 |
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