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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Dynamic magnetic resonance defecography in 10 asymptomatic volunteers显示文摘AIM: Evaluation of the wide range of normal findings in asymptomatic women undergoing dynamic magnetic resonance (MR) defecography. METHODS: MR defecography of 10 healthy female volunteers (median age: 31 years) without previous pregnancies or history of surgery were evaluated. The rectum was filled with 180 mL gadolinium ultrasound gel mixture. MR defecography was performed in the supine position. The pelvic floor was visualized with a dynamic T2-weighted sagittal plane where all relevant pelvic floor organs were acquired during defecation. The volunteers were instructed to relax and then to perform straining maneuvers to empty the rectum. The pubococcygeal line (PCGL) was used as the line of reference. The movement of pelvic floor organs was measured as the vertical distance to this reference line. Data were recorded in the resting position as well as during the defecation process with maximal straining. Examinations were performed and evaluated by two experienced abdominal radiologists without knowledge of patient history. RESULTS: Average position of the anorectal junction was located at -5.3 mm at rest and -29.9 mm during straining. The anorectal angle widened significantly from 93° at rest to 109° during defecation. A rectocele was diagnosed in eight out of 10 volunteers showing an average diameter of 25.9 mm. The bladder base was located at a position of +23 mm at rest and descended to -8.1 mm during defecation in relation to the PCGL. The bladder base moved below the PCGL in six out of 10 volunteers, which was formally defined as a cystocele. The uterocervical junction was located at an average level of +43.1 mm at rest and at +7.9 mm during straining. The uterocervical junction of three volunteers fell below the PCGL; described formally as uterocervical prolapse. CONCLUSION: Based on the range of standard values in asymptomatic volunteers, MR defecography values for pathological changes have to be re-evaluated. | Andreas G Schreyer Christian Paetzel Alois Fürst Lena M Dendl Elisabeth Hutzel René Müller-Wille Philipp Wiggermann Stephan Schleder Christian Stroszczynski Patrick Hoffstetter | 2012 | World Journal of Gastroenterology2012，18，46： | 7 |
| 3 | Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis显示文摘One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation(FMT) in active collagenous colitis(CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC. | Sezin Günaltay Lech Rademacher Elisabeth Hultgren Hornquist Johan Bohr | 2017 | World Journal of Gastroenterology2017，23，7： | 4 |
| 4 | Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project显示文摘Every year,numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment.The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount.However,collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge.This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents,primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies.An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely,considering the impact of a disaster on the environment and public health in the short,medium,and long terms.The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible.This methodology will aid defensible decision making,communication,planning,and risk management,and presents a harmonized understanding of the associated impacts of an environmental emergency. | Emma-Jane Goode Eirian Thomas Owen Landeg Raquel Duarte-Davidson Lisbeth Hall Jolanda Roelofs Sjors Schulpen Arnout De Bruin Elisabeth Wigenstam Birgitta Liljedahl Annica Waleij Louise Simonsson Ann Göransson Nyberg | 2021 | International Journal of Disaster Risk Science2021，12，4： | 2 |
| 5 | Chemotherapy in elderly patients with advanced non-small cell lung cancer显示文摘 | Elisabeth Quoix Virginie Westeel Gérard Zalcman Bernard Milleron | 2011 | Lung Cancer2011，，3： | 2 |
| 6 | Successful living donor intestinal transplantation in crossmatch positive recipients: Initial experience显示文摘Sensitized patients tend to have longer waiting times on the deceased donor list and are at increased risk of graft loss from acute or chronic rejection compared to non-sensitized candidates. Desensitization protocols are utilized to decrease the levels of alloantibodies and to convert an initial positive cross-match to prospective donors into a negative crossmatch. These procedures are mostly available in the setting of living donation. Due to the elective nature of the procedure, desensitization protocols can be extended until the desire result is obtained prior to transplantation. We present two cases of successful desensitization protocol applied to living donor intestinal transplant candidates that converted to negative cross-match to their donors. We present two cases of intestinal transplant candidates with a potential living donor to whom they are sensitized. Both cases underwent successful transplantation after desensitization protocol. No evidence of humoral rejection has occurred in either recipient. Living donor intestinal transplantation in sensitized recipients against the prospective donors provides the ability to implement a desensitization protocol to convert to negative crossmatch. | Raquel Garcia-Roca Ivo G Tzvetanov Hoonbae Jeon Elisabeth Hetterman Jose Oberholzer Enrico Benedetti | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 2 |
| 7 | The lectin-cell interaction and its implications to intestinal lectin-mediated drug delivery显示文摘 | Franz G Elisabeth B Andrea W | 2004 | Adv Drug Deliv Rev2004，56，4： | 1 |
| 8 | Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolyers显示文摘 | Geraldine A Carl W Elisabeth G | 2001 | Int Vitro Cell Dev Biol2001，37，： | 1 |
| 9 | Wavelength tunable passively mode-locked bismuth oxidebased erbium-doped fiber laser 显示文摘 | HIDEYUKI S JULIET T G ELISABETH M K | 2004 | Optics Communications2004，237，46： | 1 |
| 10 | Mapping 1995 global anthropogenic emissions of Hg显示文摘 | Jozef M P Elisabeth G P Frits S | 2003 | Atmosphere Environment2003，37，1： | 1 |
| 11 | Estrogenic and antiestrogenic regulation of MMP-2 and MMP-13 mRNA in RUCA-I endometrial tumor cells in vitro and in vivo显示文摘 | Ludger Tüshaus Anne-Christine Hopert Elisabeth Strunck Christine Schubert Winfried Wünsche Günter Vollmer | 2003 | Cancer Letters2003，，： | 1 |
| 12 | Different expression of two isopentenyl pyrophosphate isomerases and enhanced carotenoid accumulation in a unicellular chlorophyte显示文摘 | Francis X C Elisabeth G | 1998 | Proc Natl Acad Biology1998，95，11： | 1 |
| 13 | Topical lidocaine re-duces the risk of perioperative airway complications in children with upper respiratory tract infections 显示文摘 | Karl S Elisabeth G Astrid C | 2010 | Can J Anesth2010，57，8： | 1 |
| 14 | Antiinflammatory Activities of a New Series of Selective Phosphodiesterse 4 Inhibitors Derived from 9-Benzylad-enine显示文摘 | ELISABETH B JOHN L W NOELLA G | 2000 | J Pharmacol Exp Ther2000，292，2： | 1 |
| 15 | Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouraeil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer 显示文摘 | Adalsteinn G Elisabeth K Per N | 2007 | Acta Oncologica2007，46，： | 1 |
| 16 | Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in In Vitro fertilization-embryo transfer patients显示文摘 | Monika W Diego G Elisabeth P | 2009 | J Assist Reprod Genet2009，26，6： | 1 |
| 17 | Osmotic adjustment,gasexchanges and chlorophyll fluorescence of a hexaploid triticaleand its parental species under salt stress显示文摘 | Annick M Elisabeth P Gérard T | 2004 | Journal ofPlant Physiology2004，161，1： | 1 |
| 18 | Stable isotope dilution as-say for the accurate determination of mycotoxins in maize by UPLC-MS/MS显示文摘 | Elisabeth V Thomas G Robert K | 2012 | Anal Bioanal Chem2012，402，9： | 1 |
| 19 | Typologies of crop-drought vulnerability: an empirical analysis of the socio-economic factors that influence the sensitivity and resilience to drought of three major food crops in China (1961-2001)显示文摘 | Simelton Elisabeth Fraser Evan D G Termansen MeRe | 2009 | Environmental Science and Policy2009，12，4： | 1 |
| 20 | 显示文摘 | REGINA M M G ELISABETH W JAMILE R R | 2007 | Bioresource Technology2007，99，： | 1 |
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