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| 1 | The Basic Helix-Loop-Helix Transcription Factor MYC1 Is Involved in the Regulation of the Flavonoid Biosynthesis Pathway in Grapevine显示文摘以前的结果显示在葡萄藤(Vitis vinifera ) ,由 MYB 抄写因素的 flavonoid 小径基因的规定与基本 helix-loop-helix 蛋白质(bHLHs ) 取决于他们的相互作用。现在的学习描述从葡萄藤的因素说出 VvMYC1 的 bHLH 的第一功能的描述。这个抄写因素种系发生地与 Arabidopsis bHLH 蛋白质,它参予 flavonoid 生合成和表皮的房间命运的控制有关。二混血儿的试金表明了的短暂倡导者和酵母 VvMYC1 身体上与劝诱 flavonoid 小径基因的倡导者的 MYB5a, MYB5b, MYBA1/A2,和 MYBPA1 交往,这在 anthocyanin 或 proanthocyanidin (PA ) 包含了合成。另外,短暂倡导者试金表明 VvMYC1 涉及它的自己的表示的反馈规定。抄本在果浆的皮肤和种子与 anthocyanins 和舞步的合成在果浆发展相互关联期间 VvMYC1 铺平,建议 VvMYC1 涉及在这些机关的 anthocyanins 和 PA 合成的规定。同样, VvMYC1 和 VvMYBA1 的短暂表示在葡萄藤暂停房间导致 anthocyanin 合成。这些结果建议 VvMYC1 是在葡萄藤控制 anthocyanin 和 PA 生合成的 transcriptional 串联的部分。 | Imene Hichri Simon C. Heppel Jeremy Pillet Celine Leon Stefan Czemmel Serge Delrot Virginie Lauvergeat Jochen Bogs | 2010 | Molecular Plant2010，3，3： | 46 |
| 2 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 3 | Microwave Synthesis of Large Few-Layer Graphene Sheets in Aqueous Solution of Ammonia显示文摘Few-layer graphene (FLG) sheets with sizes exceeding several micrometers have been synthesized by exfoliation of expanded graphite in aqueous solution of ammonia under microwave irradiation, with an overall yield approaching 8 wt.%. Transmission electron microscopy (in bright-field and dark-field modes) together with electron diffraction patterns and atomic force microscopy confirmed that this graphene material consisted mostly of mono-, bi- or few-layer graphene (less than ten layers). The high degree of surface reduction was confirmed by X-ray photoelectron and infrared spectroscopies. In addition, the high stability of the FLG in the liquid medium facilitates the deposition of the graphene material onto several substrates via low-cost solution-phase processing techniques, opening the way to subsequent applications of the material. | Izabela Janowska Kambiz Chizari Ovidiu Ersen Spyridon Zafeiratos Driss Soubane Victor Da Costa Virginie Speisser Christine Boeglin Matthieu Houllé Dominique Bégin Dominique Plee Marc-Jacques Ledoux Cuong Pham-Huu | 2010 | Nano Research2010，3，2： | 22 |
| 4 | 能使体外培养细胞长期存活的技术显示文摘美国科学家的最新研究表明Rho激酶抑制剂(Y-27632)与纤维母细胞饲养细胞合用能够诱导许多组织的正常上皮细胞以及肿瘤上皮细胞在体外无限增值,而不需要转导外源性病毒或细胞基因.例如原始前列腺和乳腺细胞重编程为基底细胞样干细胞样表型并在基底膜中形成有序的前列腺球和乳腺球.相较于筛选稀少的干细胞样细胞,在所述的生长条件下能够在活检组织获取后的5 d~6 d内产生2×106个细胞,能够从冷冻组织少于4个活细胞培养起来.持续的细胞增殖依赖于纤维母细胞饲养细胞和Y-27632两者,进行有条件重组的细胞(CRCs)保持了正常的核型和非致瘤性.该技术也能够有效建立人和啮齿类动物肿瘤细胞的培养系.例如,从人前列腺癌建立的CRCs表现出第13号染色体的不稳定性,在基底膜中的异常增殖以及在有严重合并免疫缺陷的老鼠中形成肿瘤.这种从少量活检样本和冷冻组织迅速产生许多肿瘤细胞的能力为基于细胞的诊断和治疗(包括测试化学敏感性)提供了很大机会并大大提高了生物银行的价值.另外,CRC方法能够对取自体内的上皮细胞进行遗传操作以及随后的自体体内评估. | Xuefeng Liu Virginie Ory Sandra Chapman | 2012 | 中国烧伤创疡杂志2012，24，3： | 11 |
| 5 | Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging显示文摘AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical imaging.METHODS: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P < 0.005). ELISA confirmed that MPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided tools to better understand hostpathogen interactions at the early stage of disease, such as inflammatory bowel disease and colorectal cancer. | Julie Veziant Johan Gagnière Elodie Jouberton Virginie Bonnin Pierre Sauvanet Denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet | 2016 | World Journal of Clinical Oncology2016，7，3： | 10 |
| 6 | Organic matter produced by algae and cyanobacteria: Quantitative and qualitative characterization显示文摘This work aims at characterizing organic matter produced by an alga Euglena gracilis and a cyanobacteria Microcystis aeruginosa and assessing the evolution of its characteristics during growth.A culture medium was optimized.The species growth phases were monitored using both visible spectrophotometry and flow cytometry cell counting.Organic matter fractionation according to hydrophobicity and specific UV absorbance(SUVA) index were used to specifically characterize the produced algal organic matter(AOM).The AOM characteristics were both growth phase and species dependent.However,a similar evolution was observed.The hydrophilic fraction(HPI) was the major fraction whatever the growth phases and was almost the only one produced during lag and exponential phases.It represented around 75% of AOM during exponential phase and then decreased when the stationary phase appeared.It represented 46% and 60% of the AOM during late decline phase for the cyanobacteria and the alga respectively.The hydrophobic(HPO) and transphilic(TPH) fractions started to appear from the beginning of the stationary phase with more hydrophobic compounds coming from intracellular organic material of dying cells.HPO and TPH percentages still increased during the decline phase probably because of two additional processes:photo-dissolution and leaching of particulate organic matter from cells fragments.A comparison of AOM during late decline phase and natural organic matter(NOM) from Glane River(France) underlined that AOM was more hydrophilic and presented a lower SUVA for each fractions than NOM.However,the difference between NOM and AOM hydrophobicity narrowed during decline phase. | Maud Leloup Rudy Nicolau Virginie Pallier Claude Yprmian Geneviève Feuillade-Cathalifaud | 2013 | Journal of Environmental Sciences2013，25，6： | 10 |
| 7 | Narrative overview of animal and human brucellosis in Morocco: intensification of livestock production as a driver for emergence?显示文摘Brucellosis is one of the most widespread zoonoses in the world caused by several species of the genus Brucella.The disease,eradicated in many developed countries,is a re-emerging neglected zoonosis endemic in several zones especially in the Mediterranean region,impacting on human health and livestock production.A One Health approach could address brucellosis control in Morocco but scarcity of reliable epidemiological data,as well as underreporting,hinders the implementation of sustainable control strategies.Surveillance and control policies implemented by the Moroccan government in domestic animals(cattle and small ruminants)in the last few decades are assessed for disease impact.This study considers the origins of animal brucellosis in Morocco and the potential for emergence of brucellosis during a shift from extensive to intensive livestock production. | Marie J.Ducrotoy Khaoula Ammary Hicham Ait Lbacha Zaid Zouagui Virginie Mick Laura Prevost Ward Bryssinckx Susan CWelburn Abdelali Benkirane | 2015 | Infectious Diseases of Poverty2015，4，1： | 9 |
| 8 | 硅橡胶涂层织物表面能及稳定性研究显示文摘采用动态测量法,对液滴在硅橡胶涂层表面上的接触角进行测量及计算表面能。并对硅橡胶涂层织物进行特殊处 理,使其表面性能稳定、表面能降低、提高拒水耐脏能力。 | 狄剑锋 PERWUELZ Anne GUEGUEN Virginie LAM Thanh My | 2001 | 纺织学报2001，22，5： | 5 |
| 9 | WONCA研究论文摘要汇编--老年亚临床甲状腺功能减退治疗策略的国际变化趋势:一项基于案例的调查显示文摘背景关于亚临床甲状腺功能减退治疗效果的证据十分有限,特别是对于老年患者的治疗效果。目的探讨全科医生在不同国家和针对不同类型的患者对老年亚临床甲状腺功能减退治疗的不同方式。设计和环境在荷兰、德国、英格兰、爱尔兰、瑞士和新西兰进行基于案例的全科医生调查。方法评估全科医生对于8例表现为亚临床甲状腺功能减退患者的治疗策略(治疗是/否,起始剂量甲状腺素)。患者的特征如年龄(70岁与85岁),活力状态(充满活力与脆弱)和促甲状腺激素(TSH)浓度(6 m U/L与15 m U/L)均有差异。结果共有526名全科医生参与此项研究(瑞士262名、荷兰129名、德国61名、新西兰31名、英格兰22名、爱尔兰21名,总有效率为19%)。不同国家的治疗策略会有所不同。相比较于来自德国(平均治疗比例为73%)、爱尔兰(平均治疗比例为62%)和瑞士(平均治疗比例为52%)的全科医生,来自荷兰(平均治疗比例为34%)、英格兰(平均治疗比例为40%)和新西兰(平均治疗比例为39%)的全科医生更加不倾向于实施治疗(P=0.05)。总体来讲,全科医生更倾向于对70岁的女性患者实施治疗,而不是85岁的女性患者〔比值比=0.74,95%CI(0.63,0.87)〕。TSH为15 m U/L的患者比TSH为6m U/L的患者更易于得到治疗〔比值比=9.49,95%CI(5.81,15.5)〕。结论全科医生对于不同国家和不同类型的老年亚临床甲状腺功能减退患者的治疗策略有很大差异,而这种差异说明有必要建立新一代基于初级卫生医疗随机临床试验的国际指南。 | den Elzen WP Lefèbre-van de Fliert AA Virgini V 周淑新 | 2015 | 中国全科医学2015，18，12： | 4 |
| 10 | Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn’s Disease显示文摘 | Pierre Desreumaux Arnaud Foussat Matthieu Allez Laurent Beaugerie Xavier Hébuterne Yoram Bouhnik Maria Nachury Valérie Brun Hervé Bastian Nathalie Belmonte Michel Ticchioni Agnès Duchange Patricia Morel–Mandrino Virginie Neveu Nathalie Clerget–Chossat Mig | 2012 | Gastroenterology2012，，5： | 4 |
| 11 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 12 | Microscopic features of colorectal neoplasia in inflammatory bowel diseases显示文摘The risk of developing dysplasia leading to colorectal cancer(CRC)is increased in both ulcerative colitis and Crohn’s disease.The prognosis of CRC may be poorer in patients with inflammatory bowel disease(IBD)than in those without IBD.Most CRCs,in general,develop from a dysplastic precursor lesion.The interpretation by the pathologist of the biopsy will guide decision making in clinical practice:colonoscopic surveillance or surgical management.This review summarizes features of dysplasia(or intraepithelial neoplasia)with macroscopic and microscopic characteristics.From an endoscopic(gross)point of view,dysplasia may be classified as flat or elevated(raised);from a histological point of view,dysplasia is separated into 3 distinct categories:negative for dysplasia,indefinite for dysplasia,and positive for dysplasia with low-or high-grade dysplasia.The morphologic criteria for dysplasia are based on a combination of cytologic(nuclear and cytoplasmic)and architectural aberrations of the crypt epithelium.Immunohistochemical and molecular markers for dysplasia are reviewed and may help with dysplasia diagnosis,although diagnosis is essentially based on morphological criteria.The clinical,epidemiologic,and pathologic characteristics of IBD-related cancers are,in many aspects,different from those that occur sporadically in the general population.Herein,we summarize macroscopic and microscopic features of IBD-related colorectal carcinoma. | Aude Bressenot Virginie Cahn Silvio Danese Laurent Peyrin-Biroulet | 2014 | World Journal of Gastroenterology2014，20，12： | 4 |
| 13 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 14 | Combining Metabolomics and Gene Expression Analysis Reveals that Propionyl- and Butyryl- Carnitines Are Involved in Late Stages of Arbuscular Mycorrhizal Symbiosis显示文摘arbuscular mycorrhizal (AM ) 共生是在土壤真菌(Glomeromycota ) 和 theroots 之间的一个普遍 mutualistic 协会大多数植物种类。AM 真菌是要求其开发部分在他们的 planthost 的控制下面的 biotrophs。我们探索了可能性联合 metabolomic 和 transcriptomic 途径发现通常认为的 mycorrhiza-associatedmetabolites 调整 AM 真菌的开发。与 AM 真菌 Rhizophagus irregularis 开拓殖民地于的 Medicago truncatula 根的甲醇摘录被极端高效的液体层析(UHPLC ) 分析并且比较,高分辨率的集体 spectrometry (Q-TOF ) ,和 multivariate 统计辨别。我们检测了只在场的 71 联系 mycorrhiza 的 analytes 或在更充满 mycorrhizal 根的 least10 褶层。为了在这些 analytes 之中识别那些,那能调整 AM 真菌的开发,我们由准备、半准备的 HPLC 的 fractionated mycorrhizal 和 non-mycorrhizal 根摘录和 establishedhow 71 analytes 在部分之中被散布。然后,我们在发芽 sporesof R 上测试了部分的活动。由确定的 irregularis 知道为的 96 基因的表示他们的在 planta 表示模式多样。这些调查揭示在 mycorrhizal roots.The 结果积累的那 propionyl 肉毒碱和 butyryl 肉毒碱建议这二个分子在 planta 调整真菌的基因表示并且为进一步生物的 characterization.Key 词代表有趣的候选人: | Jerome Laparre | 2014 | Molecular Plant2014，7，3： | 3 |
| 15 | 植物提取物在抗球虫中的应用显示文摘全球范围内,球虫病都被视为家禽养殖中耗费最高的寄生虫病。若将预防、药物和由于死亡、发病以及采食量下降引起的家禽生产力损失考虑在内,每年会损失约8亿美元。仅在鸡球虫病的预防方面,全球每年就花费约3亿美元。 | Virginie Noirot 金灵 | 2010 | 广东饲料2010，19，10： | 3 |
| 16 | Functionalization of Single- and Multi-Walled Carbon Nanotubes with Cationic Amphiphiles for Plasmid DNA Complexation and Transfection显示文摘The possibility of delivering DNA effi ciently to cells represents a crucial issue for the treatment of both genetic and acquired diseases.However,even although the effi ciency of non-viral transfection systems has improved in the last decade,none have yet proven to be suffi ciently effective in vivo.We report herein our results on the functionalization of single-walled carbon nanotubes(SWNT)and multi-walled carbon nanotubes(MWNT)by two cationic amphiphiles(lipid RPR120535 and pyrenyl polyamine),their use for the complexation of plasmid DNA,and their efficiency in transfecting cells in vitro.The experiments have shown that the efficiency of transfection is higher when using SWNT instead of MWNT,and that transfection effi ciency is similar or slightly higher when using nanoplexes(SWNT/lipid RPR120535/DNA)instead of lipoplexes(lipid RPR120535/DNA)and several orders of magnitude higher than that of naked DNA.This study therefore shows both that the transfection is better when using SWNTs and that it is dependent on the nature of the amphiphilic molecules adsorbed on the nanotubes. | Cyrille Richard Nathalie Mignet Céline Largeau Virginie Escriou Michel Bessodes Daniel Scherman | 2009 | Nano Research2009，2，8： | 3 |
| 17 | Chemotherapy in elderly patients with advanced non-small cell lung cancer显示文摘 | Elisabeth Quoix Virginie Westeel Gérard Zalcman Bernard Milleron | 2011 | Lung Cancer2011，，3： | 2 |
| 18 | A role for peroxisome proliferator‐activated receptor gamma in resveratrol‐induced colon cancer cell apoptosis显示文摘 | Virginie Aires Bertrand Brassart Annie Carlier Alessandra Scagliarini Stéphane Mandard Emeric Limagne Eric Solary Laurent Martiny Michel Tarpin Dominique Delmas | 2014 | Mol. Nutr. Food Res2014，，9： | 2 |
| 19 | Glucose Metabolism in 105 Children and Adolescents After Pancreatectomy for Congenital Hyperinsulinism显示文摘 | Beltrand Jacques Caquard Marylène Arnoux Jean-Baptiste Laborde Kathleen Velho Gilberto Verkarre Virginie Rahier Jacques Brunelle Francis Nihoul-Fékété Claire Saudubray Jean-Marie Robert Jean-Jacques de Lonlay Pascale | 2012 | Diabetes Care2012，，2： | 1 |
| 20 | Overexpression, physicochemical characterization, and modeling of a hyperthermophilic pyrococcus furiosus type 2 IPP isomerase显示文摘 | RaphaEl D J6r6me de R Virginie | 2008 | Proteins2008，71，4： | 1 |
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