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| 1 | Beta-7 integrin controls enterocyte migration in the small intestine显示文摘AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleoside analog Brd U was ip injected in beta-7-deficient mice(C57BL/6-Itgbtmlcgn/J)of male gender and age-matched male C57BL/J J mice(wild type)4,20,or 40 h before analysis.The total small intestine was isolated,dissected,and used for morphometrical studies.Brd U-positive epithelial cells were numbered in at least 15 hemi-crypts per duodenum,jejunum,and ileum of each animal.The outer most Brd U-positive cell(cellmax)was determined per hemi-crypt,numerically documented,and statistically analysed.RESULTS:Integrins containing the beta-7-chain were exclusively expressed on leukocytes.In the small intestinal mucosa of beta-7 integrin-deficient mice the number of intraepithelial lymphocytes was drastically decreased.Moreover,the Peyer’s patches of beta-7integrin-deficient mice appeared hypoplastic.In beta-7integrin-deficient mice the location of cellmax was found in a higher position than it was the case for the controls.The difference was already detected at 4 h after Brd U application,but significantly increased with time(40 h after Brd U injection)in all small intestinal segments investigated,i.e.,duodenum,jejunum,and ileum.Migration of small intestinal enterocytes was different between the experimental groups measured by cellmax locations.CONCLUSION:The E-cadherin beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer. | Elke Kaemmerer Paula Kuhn Ursula Schneider Thomas Clahsen Min Kyung Jeon Christina Klaus Julia Andruszkow Michael Hrer Sabine Ernst Angela Schippers Norbert Wagner Nikolaus Gassler | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 2 | Mortality in Pennsylvania 显示文摘 | Arthur L H Daniel captive elk ( Cervus 2007 19(3) : 334 P S Jenny S F elaphus) : 1998-2006 -337 | 2007 | J Vet Diagn Invest2007，，： | 1 |
| 3 | Cerebral gliomas: diffusional kurtosis imaging analysis of microstructural difference 显示文摘 | Peter R Elke H Kea F | 2010 | Radiology2010，254，6： | 1 |
| 4 | Risk as feelings显示文摘 | boewenstein G F Elke U W Christopher K H Welch N | 2001 | Psychological Bulletin2001，127，2： | 1 |
| 5 | The yield gap of global grain production: A spatial analysis显示文摘 | Kathleen N Peter H V Elke S | 2010 | Agricultural Systems2010，103，5： | 1 |
| 6 | Principles and phenomena of bioengineering with glass-ceramics for dental restoration 显示文摘 | Wolfram H Volker R Elke A | 2007 | Journal of the European Ceramics Society2007，27，： | 1 |
| 7 | Biological sulfate removal from tannery wastewater in a two - stage anaerobic 显示文摘 | Elke G Werner H Christian M | 1996 | Water Research1996，30，9： | 1 |
| 8 | Irradiance forecasting for the power prediction of grid-connected photovoltaic systems 显示文摘 | ELKE L HURKA J DETLEV H | 2009 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2009，2，1： | 1 |
| 9 | Identity and entrepreneur- ship: Do school peers shape entrepreneurial intentions? 显示文摘 | Oliver F Stephan H Elke L | 2012 | SmallBusiness Economics2012，39，1： | 1 |
| 10 | Role of PI3K in mediating short- and long-term effects of IGF-1 on calcium handling in adult cardiac myocytes显示文摘 | Elke A D Virginie B Christel H | 2007 | J Mol Cell Cardiol2007，42，6： | 1 |
| 11 | Laccase-induced cross-coupling of 4-aminobenzoic acid with para-dihydroxylated compounds 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide and 2,5-dthydroxybenzoic acid methyl ester显示文摘 | Katrin M Elke H Annett M T | 2005 | Journal of Molecular Catalysis B: Enzymatic2005，，35： | 1 |
| 12 | Combining road safety information in a performance index显示文摘 | Elke H Filip Van den B Geert W | 2008 | Accident Analysis and Prevention2008，，40： | 1 |
| 13 | Systemic Spread Is an Early Step in Breast Cancer显示文摘 | Yves Hüsemann Jochen B. Geigl Falk Schubert Piero Musiani Manfred Meyer Elke Burghart Guido Forni Roland Eils Tanja Fehm Gert Riethmüller Christoph A. Klein | 2008 | Cancer Cell2008，，1： | 1 |
| 14 | 查看详情显示文摘 | ELKE H CARLO M MARIA J | | 0，，： | 1 |
| 15 | Increased dietary intake of co-3 polyunsaturated fatty acidsreduces pathological retinal angiogenesis显示文摘 | Kip M C San Giovanni J P Lofqvist C Christopher M A Chen J HiguchiA Hong S Elke A P Majchrzak S Carper D Ann H Kang J X Emily Y C Norman S Charles N S | 2007 | Nature Medicine2007，13，： | 1 |
| 16 | Specific effects of fructo- and gluco-oligosaccharides in the preservation of liposomes during drying显示文摘 | Dirk k Hincha Ellen Zuther Elke M H | 2002 | Glycobiology2002，12，2： | 1 |
| 17 | Synthesis and Characterization of Some 4-Keto Derivatives of 1,3,4 (2H) - Isoquinolinetrione Redox Mediator Herbicides显示文摘 | CLEMENS L ELKE H DENIS B | 2000 | Pest Manage Sci2000，56，： | 1 |
| 18 | Rapid and highly sensitive pathotyping of avian influenza A H5N1 virus by using real-time reverse transcription-PCR显示文摘 | Bernd H Timm H Elke S | 2007 | J Clin Microbiol2007，45，： | 1 |
| 19 | Laccase-induced cross-coupling of 4-aminobenzoic acid withpara-dihydroxylated compounds 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide and 2,5-dihydroxybenzoic acid methyl ester显示文摘 | Katrin M Elke H Annett M T | 2005 | Journal of Molecular Catalysis B:Enzymatic2005，，35： | 1 |
| 20 | Multiple control of interleukin-8 gene expression 显示文摘 | Elke H Oliver DB Helmut H | 2002 | J Leukocyte Biol2002，72，5： | 1 |
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