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| 1 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 2 | Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin 显示文摘 | Edman J C Ellis L Blacher R W | 1985 | Nature1985，317，6034： | 1 |
| 3 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas sys- t eras显示文摘 | Zhang T W Ellis G S Ruppel S C | | Organic Geochemistry0，47，： | 1 |
| 4 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas systems显示文摘 | Zhang T W Ellis G S Ruppel S C | 2012 | Organic Geochemistry2012，47，6： | 1 |
| 5 | Sequence of protein disul- phide isomerase and implications of its relationship to thiore- doxin 显示文摘 | Edmem J C Ellis L Blacher R W | 1985 | Nature1985，317，： | 1 |
| 6 | Stress-strain modeling of sands using artificial neural networks显示文摘 | Ellis G W Yao C Zhao R | 1995 | Journal of Geotechnical Engineering1995，121，5： | 1 |
| 7 | Vaccination of chickens against HSN1 Avian influenza in the face of an outbreak interrupts virus transmission 显示文摘 | Ellis T M Leung C Y H C Chow M K W | 2004 | Avian Pathol2004，33，4： | 1 |
| 8 | Temperature effects on feed utilization and growth of post settlement stage Nassau grouper 显示文摘 | Ellis C S Watunabe W O Ellis E P | 1997 | Trans Amer Fish Soc1997，126，： | 1 |
| 9 | Vapor-liquid-solid mechanism of crystal growth显示文摘 | WANGER R S ELLIS W C | 1964 | Appl Phys Lett1964，4，5： | 1 |
| 10 | Vapor-liquid-solid mechanism of single crystal growth显示文摘 | Wangner R S Ellis W C | 1964 | Appl Phys Lett1964，4，5： | 1 |
| 11 | Application of an absorber to re-duce helicopter vibration levels显示文摘 | Ellis C W Jones R | 1963 | Journal of the A-merican Helicopter Society1963，8，3： | 1 |
| 12 | Vapor·liquid·solid mechanism of sigle crystal growth显示文摘 | ELLIS W C | 1964 | Applied Physics Letters1964，，4： | 1 |
| 13 | Vapor-Liquid-solid Mechanism of Single Crystal Growth 显示文摘 | Wagner R S Ellis W C | 1964 | Appl Phy Lett1964，4，： | 1 |
| 14 | Morphology of whisker crystals of Sn, Zn, and Cd grown spontaneously from the solid显示文摘 | ELLIS W C | 1966 | Transactions of the Metal Society of AIME1966，236，： | 1 |
| 15 | Selective ring opening of naphthenic molecules显示文摘 | McVicker G B Daage M Touvelle M S Hudson C W Klein D P Baird W C Cook B R Chen J G Hantzer S Vaughan D E W Ellis E S Feeley O C | | 0，，01： | 1 |
| 16 | Paclitaxel-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents:the TAXUS V ISR randomized trial显示文摘 | STONE G W ELLIS S G O'SHAUGHNESSY C D | 2006 | JAMA2006，295，： | 1 |
| 17 | Temperature effects on feed utilization and growth of postsettlement stage Nassau grouper显示文摘 | Ellis C S Watunabe W O Ellis E P | 1997 | Trans Amer Fish Soc1997，126，： | 1 |
| 18 | Stress-strain Modeling of Sands Using Artificial Neural Networks显示文摘 | Ellis G W Yao C Zhao R | 1995 | Journal of Geotechnical Engineering1995，121，5： | 1 |
| 19 | Vapor-liquid-solid mechanism of single crystal growth显示文摘 | Wagner R S Ellis W C | 1964 | Appl Phys Lett1964，4，： | 1 |
| 20 | Ageochem/eal classification for granitierocks 显示文摘 | Forst B R Barnes C G Collins W J Arculus R J Ellis D J Frost C D | 2001 | Journal of Petrology2001，42，： | 1 |
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