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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Hybrid stochastic approach for the modeling and analysis of fire safety systems 显示文摘 | EMILIA V PERCY I K PAULO E M | 2006 | Nonlinear Analysis2006，65，： | 1 |
| 3 | Did Good Corporate Governance Improve Bank Performance during the Financial Crisis?显示文摘 | Emilia Peni Sami V?h?maa | 2012 | Journal of Financial Services Research2012，，1： | 1 |
| 4 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 5 | Structural and optical properties of silicon quantum dots in silicon nitride grown in situ by PECVD using different gas precursors显示文摘 | Lucia V Mercaldo Paola Delli Veneri Emilia Esposito | 2009 | Mater Sci Eng B2009，1591，60： | 1 |
| 6 | PECVD in-situ growth of silicon quantum dots in silicon nitride from silane and nitrogen 显示文摘 | Lucas V M Paolo D V Emilia E | 2009 | Materials Science and Engineering B2009，，： | 1 |
| 7 | Did Good Corporate Governance Improve Bank Performance during the Financial Crisis?显示文摘 | Emilia Peni Sami V?h?maa | 2012 | Journal of Financial Services Research (-)2012，，1： | 1 |
| 8 | A Petri net approach for the design and analysis of Web services choreographies 显示文摘 | VALENTIN V EMILIA M C GREGORIO D | 2009 | The Journal of Logic and Algebraic Programming2009，78，5： | 1 |
| 9 | Enzymatic esterification of starch using recovered coconut oil显示文摘 | Akhila Rajan V S Prasad T Emilia Abraham | 2006 | International Journal of Biological Macromolecules2006，39，： | 1 |
| 10 | Influence of ripeness grade on accumulation and extractability of grape skin anthocyanins in different eul- tivars显示文摘 | SUSANA R S ELVIRA S V EMILIA D L | 2008 | Journal of Food Composition and Analysis2008，21，： | 1 |
| 11 | Application of zeolitised coal fly ashes to the depuration of liquid wastes 显示文摘 | Emilia O Luis F V Natalia M | 2005 | Fuel2005，84，11： | 1 |
| 12 | Knoevenagel Reaction in[MMIm][MSO4]:Synthesis of Coumarins显示文摘 | Pedro V Francisco Sand Emilia T | | 0，，： | 1 |
| 13 | GABA signalling during development: new data and old questions 显示文摘 | Patricia V Zoya K Emilia M | 2001 | Cell Tissue Res2001，305，2： | 1 |
| 14 | Immobilization of Horseradish Peroxidase on Chitosan for Use in Nonaqueous Media显示文摘 | Bindhu L V Emilia T A | 2003 | Journal of Applied Polymer Science2003，88，6： | 1 |
| 15 | Effect of simvastatin on endothelial function in cardiac syndrome X patients显示文摘 | Emilia F Albert V Eugenio P | 2004 | The Americian Journal of Cardiology2004，94，： | 1 |
| 16 | Application of zeolitised coal fly ashes to the depuration of liquid wastes 显示文摘 | Emilia O Luis F V Natalia M | 2005 | Fuel2005，84，11： | 1 |
| 17 | Preparation and kinetic studies of surfactant-horseradish peroxidase ion paired complex in organic media 显示文摘 | BINDHU L V EMILIA A T | 2003 | Biochemical Engineering Journal2003，15，1： | 1 |
| 18 | Effect of heat treatment on the nutritive value of wheat germ显示文摘 | Kumar G V Emilia V T Haridas R P | 1980 | Journal of Food Science and Technology1980，17，6： | 1 |
| 19 | Mathematical modeling of light naphtha(C5,C6)isomerization process显示文摘 | Nikita V Chekantsev Maria S Gyngazova Emilia D Ivanchina | 2014 | Chemical Engineering Journal2014，，238： | 1 |
| 20 | Down regulation of endotoxin-indueed uveitis by intravitreal injection of polylaetie-glycolie acid (PLGA) microspheres loaded with dexamethasone显示文摘 | Emilia B Roelo H V Ana D | 2009 | Experimental Eye Research2009，89，2： | 1 |
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