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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Satellite Remote Sensing Analysis to Monit- or Desertification Processes in the Crop-rangeland Boundary of Argentina显示文摘 | Alfredo D C Emilio C Camarasaw A | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 3 | Satellite remote sensing analysis to monitor desertification processes in the crop-range- Iand boundary of Argentina显示文摘 | Alfredo D C Emilio C Camarasa A | 2002 | Journal of Arid Environment2002，52，1： | 1 |
| 4 | Phenol photodegradation on platinized-TiO2 photocatalysts related to charge-carrier dynamics显示文摘 | Emilio C A Litter M I Kunst M | 2006 | Langmuir2006，22，8： | 1 |
| 5 | Satellite remote sensing analysis to monitor desertification processesin the croprangeland boundary of argentina显示文摘 | Alfredo D C Emilio C Camarasaw A | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 6 | Highly stereoselective reduction of haloketones using three new yeasts: application to the synthesis of (S)-adrenergic β-blockers related to propranolol 显示文摘 | Fernando M L Jose D C Jose L B Emilio A Jose V S | 2004 | Tetrahedron: Asymmetry2004，15，： | 1 |
| 7 | Serum levels of chemokines in adolescents with major depression treated with fluoxetine显示文摘BACKGROUND Major depressive disorder(MDD)is a global health issue that affects 350 million people of all ages.Although between 2%and 5.6%of affected individuals are adolescents,research on young patients is limited.The inflammatory response contributes to the onset of depression,and in adult MDD patients,symptom severity has been linked to chemokine levels.AIM To determine the differences in circulatory levels of chemokines in healthy volunteers(HVs)and adolescents with MDD,and assess the changes induced by fluoxetine consume.METHODS The 22 adolescents with MDD were monitored during the first 8 wk of clinical follow-up and clinical psychiatric evaluation was done using the Hamilton depresión rating scale(HDRS).The serum levels of monocyte chemoattractant protein-1(MCP-1),macrophage inflammatory protein(MIP)-1α,MIP-1β,interleukin(IL)-8,interferon gamma-induced protein(IP)-10,and eotaxin were measured in patients and HVs.RESULTS In all cases,significant differences were detected in circulating chemokine levels between patients before treatment and HVs(P<0.0001).All chemokines decreased at 4 wk,but only MCP-1 and IL-8 significantly differed(P<0.05)between 0 wk and 4 wk.In the patients,all chemokines rose to their initial concentrations by 8 wk vs 0 wk,but only IP-10 did so significantly(P<0.05).All patients experienced a significant decrease in HDRS scores at 4 wk(P<0.0001)and 8 wk(P<0.0001)compared with 0 wk.CONCLUSION Despite the consumption of fluoxetine,patients had significantly higher chemokine levels,even after considering the improvement in HDRS score.The high levels of eotaxin,IP-10,and IL-8 partially explain certain aspects that are affected in MDD such as cognition,memory,and learning. | Francisco Rafael de la Peña Carlos Cruz-Fuentes Lino Palacios Manuel Iván Girón-Pérez Emilio Medina-Rivero Maria Dolores Ponce-Regalado Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva JoséLuis Maldonado-García María C Jiménez-Martínez Lenin Pavón | 2020 | World Journal of Psychiatry2020，10，8： | 1 |
| 8 | Seasonal furrow irrigation model with genetic algorithms (OPTIMEC) 显示文摘 | Pilar M Emilio C Serafin A | 2001 | Agricultural Water Manage- ment2001，52，1： | 1 |
| 9 | Satellite remote sensing analysis to monitor desertification processes in the croprange-land boundary of Argentina 显示文摘 | AlfredoD C Emilio C Camarasaw A | 2002 | Journal of Arid Environments2002，52，1： | 1 |
| 10 | Control of charge recombination dynamics in dye sensitized solar cells by the use of conformally deposited metal oxide blocking layers显示文摘 | Emilio P John N C Sail A H | 2003 | J Am Chem Soe2003，125，： | 1 |
| 11 | The Complexity of Theories on Rural Development in Europe:An Analysis of the Paradigmatic Case of Almería (South-east Spain)显示文摘 | EMILIO GALDEANO-GóMEZ JOSé A AZNARSáNCHEZ JUAN C PéREZ-MESA | | 0，，51： | 1 |
| 12 | Contrast volume during primary pereutaneous coronary intervention and subsequent contrast - induced nephropathy and mortality 显示文摘 | Giancarlo M Emilio A Jeness C | 2009 | Ann Inter Med2009，150，3： | 1 |
| 13 | Biofilm Con- trol in Tubular Heat Exchangers Refrigerated by Sea- water Using Flow Inversion Physical Treatment 显示文摘 | Emilio E Trueba A Bel6n R C | 2008 | International Biodeterioration & Biodegradation2008，62，2： | 1 |
| 14 | Satellite remote sensing analysis to monitor desertification processing the crop range - land boundary of argentina 显示文摘 | Alfredo D C Emilio C Camarasaw A | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 15 | Satellite Remote Sensing Analysis to Monitor Desertification Processes in the Cro Prangeland Boundary of Argentina 显示文摘 | Alfredo D C Emilio C Camarasaw A | 2002 | Journal of Arid Environments2002，52，： | 1 |
| 16 | Satellite Remote Sensing Analysis to Monitor Desertification Processes in the Croprangeland Boundary of Argentina显示文摘 | Alfredo D C emilio C Camarasaw A | 2002 | Journal of A rid environments2002，52，： | 1 |
| 17 | Kinetics and mechanisms of EDTA photocatalytic degradation with TiO2显示文摘 | BABAY P A EMILIO C A FERREYRA R E | 2001 | Water Science& Technology2001，44，5： | 1 |
| 18 | Finite element method for transmission line corona effect simulation using the EMTP显示文摘 | Miranda G C D Emilio A Araujo A D | 1999 | Electric Machines and Power Systems1999，27，7： | 1 |
| 19 | Finite Element Method for Transmission Line Corona Effect Simulation Using the EMTP显示文摘 | Miranda G C D Emilio A Araujo A Dm | 1999 | Electric Machines and Power Systems1999，27，7： | 1 |
| 20 | Probabilistic lifetime assessment of RC structures under coupled corrosion-fatigue deterioration processes 显示文摘 | EMILIO B A PHILIPPE B ALAA C | 2009 | Struct Safety2009，31，： | 1 |
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