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| 1 | Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C显示文摘AIM:To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus(HCV)infection.METHODS:The study included 30 children with chronic HCV infection before receiving antiviral therapy.Chronic HCV infection was defined by positive anti-HCV,a positive polymerase chain reaction for HCV-RNA for more than 6 mo with absence of any associated liver disease.A second group of 30 age-and sex-matched healthy children served as controls.Serum C4a levels were measured by enzyme-linked immunosorbent assay.Liver fibrosis stage and inflammatory grade were assessed using Ishak scoring system.Serum C4a levels were compared according to different clinical,laboratory and histopathological parameters.Statistical significance for quantitative data was tested by MannWhitney U non-parametric tests.For qualitative data,significance between groups was tested by 2test.Correlation was tested by Spearman’s test.Results were considered significant if P value≤0.05.RESULTS:The age of the patients ranged from 3.5to 18 years and that of controls ranged from 4 to 17years.C4a mean levels were merely lower in patients(153.67±18.69 mg/L)than that in the controls(157.25±11.40 mg/L)with no statistical significance(P=0.378).It did not differ significantly in patients with elevated vs those with normal transaminases(152.25±16.62 vs 155.36±21.33;P=0.868)or with different HCV viremia(P=0.561).Furthermore,there was no statistical significant difference in serum levels between those with no/mild fibrosis and those with moderate fibrosis(154.65±20.59 vs 152.97±17.72;P=0.786)or minimal and mild activity(155.1±21.93 vs 152.99±17.43;P=0.809).Though statistically not significant,C4a was highest in fibrosis score 0(F0),decreasing in F1 and F2 to be the lowest in F3.When comparing significant fibrosis(Ishak score≥3)vs other stages,C4a was significantly lower in F3 compared to other fibrosis scores(143.55±2.33 mg/L vs 155.26±19.64 mg/L;P=0.047)and at a cutoff value of less than 144.01 mg/L,C4a could discriminate F3 with 76.9%sensitivity and75%specificity from other stages of fibrosis.CONCLUSION:Serum complement C4a did not correlate with any of transaminases,HCV viremia or with the histopathological scores.Although C4a decreased with higher stages of fibrosis,this change was not significant enough to predict individual stages of fibrosis.Yet,it could predict significant fibrosis with acceptable clinical performance. | Behairy E Behairy Ghada M El-Mashad Ragab S Abd-Elghany Enas M Ghoneim Mostafa M Sira | 2013 | World Journal of Hepatology2013，5，8： | 4 |
| 2 | Application of an innovative methodology to improve the starting-up of UASB reactors treating domestic sewage显示文摘 | Rodriguez J A P ena M R Manzi V | 2001 | Water Science and Technology2001，44，4： | 1 |
| 3 | Adenosine deami- nase activity in cerebrospinal fluid:a useful test for me- ningeal tuberculosis, even in patiens with AIDS显示文摘 | Ena J Crespo M J Vallis V | 1988 | J In- fect Dis1988，158，4： | 1 |
| 4 | A comparative study of dexmedetomidine and propofol as sole sedative agents for pa- tients with aneuysmal subarachnoid hemorrhage undergoing diagnostic cerebral angiography 显示文摘 | Sriqanesh K Reddy M J ena S | 2014 | J Anesth2014，26，2： | 1 |
| 5 | Circulating leptin and insulin in obese patients with and without type 2 diabetes mellitus: Relation to ghrelin and oxidative stress 显示文摘 | ENAS A HAMED MADEHA M ZAKARY NAGWA S AHMED | 2011 | Diabetes ''Res Clinical Practice2011，94，3： | 1 |
| 6 | Usefulness of basal and pilocarpine-stimulated salivary flow in primary Sjgren's syndrome correla-tion with clinical, immunological and histological features显示文摘 | R()SASJ RAMOS CASALS M ENA J | 2002 | Rheumatolo-gy2002，1，6： | 1 |
| 7 | Wheyprotein antigenicity reduction by fungal proteinases and apepsin/pancreatic combination显示文摘 | Ena J M Van Beresteijn E C H Robben A J P M | 1995 | Journal of Food Science1995，60，： | 1 |
| 8 | Translational medicine is developing in China: a new venue for collaboration 显示文摘 | Wang Xiangdong Wang Ena Marincola F M | 2011 | Translational Med2011，9，3： | 1 |
| 9 | Effectiveness of amiodarone for conversion of atrial fibrillation to sinus rhythm:a meta-analysis显示文摘 | Letelier L M Udol K Ena J | 2003 | Arch Intern Med2003，163，： | 1 |
| 10 | An investigational new drug treatment program for patients with gemcitabine:results for over 3000 patients with pancreatic carcinoma显示文摘 | Storniolo A M Enas N H Brown C A | 1999 | Cancer1999，85，6： | 1 |
| 11 | The metabolic syndrome and dyslipidemia among Asian Indians:a population with high rates of diabetes and premature coronary artery disease显示文摘 | Enas EA Mohan V Deepa M | 2007 | J Cardiometab Syndr2007，2，4： | 1 |
| 12 | Direction of crack propagation in a complete contact fretting-fatigue prol~lem 显示文摘 | GINER E SAI~ SABI M ROI)ENAS ] J | 2014 | International Journal of Fatigue2014，58，1： | 1 |
| 13 | Whey protein antigenicity reduction by fungal proteinases and a pepsin/ pancreatic combination显示文摘 | Ena J M Van Beresteijn E C H Robben A J P M | 1995 | Journal of Food Science1995，60，： | 1 |
| 14 | Crack tip stress fields revealed by infrared photoelasticity in silicon crystals 显示文摘 | KENJI H MASAKI T ENA M | 2004 | Materials Science and Engineering A2004，387，12： | 1 |
| 15 | Recent ad- vances in cardiac hypertrophy 显示文摘 | GIORGIO O t-:I ENA C ROBERTA M | 2000 | Cardiovascular Research2000，，： | 1 |
| 16 | Adenosine deaminase activity in cerebrospinal fluid:a useful test for meningeal tuberculosis,even in patients with AIDS显示文摘 | ENA J CRESPO M J VALLIS V | 1998 | Infect Dis1998，158，8： | 1 |
| 17 | The metabolic syndrome anddyslipidemia among Asian Indians: a population with high rates of diabetes and premature coronary artery disease显示文摘 | ENAS E A MOHAN V DEEPA M | 2007 | J Cardiometab Syndr2007，2，4： | 1 |
| 18 | High-fidelity mRNA amplification for gene profiling显示文摘 | Ena W Lance D M Galen A O | 2000 | Nat Biotech2000，18，4： | 1 |
| 19 | Kinetic and ther- modynamic parameters for heat denaturation of bovine milk IgG, IgA and IgM 显示文摘 | Mainer G Sanchez L Ena J M | 1997 | Journal of Food Science1997，62，5： | 1 |
| 20 | Aninvestigational new drug treatment program for patients with gemcitabine:results for over 3000 patients with pancreatic carcinoma显示文摘 | STORNIOLO A M ENAS N H BROWN C A | 1999 | Cancer1999，85，6： | 1 |
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