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| 1 | The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells显示文摘Streptococcus mitis(S. mitis) is a pioneer commensal bacterial species colonizing many of the surfaces of the oral cavity in healthy individuals. Yet, not much information is available regarding its interaction with the host. We used examination of its transcriptional regulation in oral keratinocytes to elucidate some of its potential roles in the oral cavity. Transcription factor analysis of oral keratinocytes predicted S. mitis-mediated activation of aryl hydrocarbon receptor(Ah R). Activation and functionality of Ah R was confirmed through nuclear translocation determined by immunofluorescence microscopy and real-time polymerase chain reaction with reverse transcription analysis of CYP1A1, the hallmark gene for Ah R activation. Addition of Streptococcus mutans or Streptococcus gordonii did not induce CYP1A1 transcription in the keratinocyte cultures. Introduction of an Ah R-specific inhibitor revealed that S. mitis-mediated transcription of CXCL2 and CXCL8 was regulated by Ah R. Elevated levels of prostaglandin E2(enzyme-linked immunosorbent assay) in supernatants from S. mitis-treated oral epithelial cells were also attenuated by inhibition of Ah R activity. The observed Ah R-regulated activities point to a contribution of S. mitis in the regulation of inflammatory responses and thereby to wound healing in the oral cavity. The concept that the oral commensal microbiota can induce Ah R activation is important, also in view of the role that Ah R has in modulation of T-cell differentiation and as an anti-inflammatory factor in macrophages. | stian a engen gro h rørvik olav schreurs inger js blix karl schenck | 2017 | International Journal of Oral Science2017，9，3： | 2 |
| 2 | Transformational, transactional, and laissez-faire leadershipstyles: A meta-analysis comparing women and men显示文摘 | EAGLY A H JOHANNESEN M C ENGEN M L | 2003 | Psychological Bulletin2003，129，4： | 1 |
| 3 | Magneto-optical properties of metallic ferromagnetic materials 显示文摘 | BUSCHOW K H J van ENGEN P G JONGEBREUR R | 1983 | Journal of Magnetism and Magnetic Materials1983，38，1： | 1 |
| 4 | Transformational,Transactional,and Laissez-faire Leadership Styles:A Meta-analysis Comparing Women and Men显示文摘 | EAGLY A H JOHANNESEN-SCHMIDT M C VAN ENGEN M L | 2003 | Psychological Bulletin2003，129，4： | 1 |
| 5 | SAR-ocean Wave Inversion Using Image Cross Specks 显示文摘 | Engen G Johnsen H | 1995 | IEEE Trails Geoscical Remote Sensing1995，33，： | 1 |
| 6 | How self-generated thought shapes mood-the relation between mind-wandering and mood depends on the socio-temporal content of thoughts 显示文摘 | RUBY F J SMALLWOOD J ENGEN H | 2013 | PLoS ONE2013，8，77： | 1 |
| 7 | Magnetic and magneto-optical properties of amorphous Al-xFex alloys (A = B, Ge, and Sn) 显示文摘 | BUSCHOW K H J VAN ENGEN P G | 1981 | Journal of Applied Physics1981，52，： | 1 |
| 8 | An exploration of stereotypical beliefs about leadershipstyles: Is transformational leadership a route to women’spromotion-显示文摘 | VINKENBURG C J ENGEN M L EAGLY A H etal | 2011 | The Leadership Quarterly2011，22，1： | 1 |
| 9 | Prospective analysis of intraoperative frozen needle biopsy of solid renal masses in adults显示文摘 | Dechet C B Sebo T Farrow G Blute M L Engen D E Zincke H | 1999 | J Uro11999，162，： | 1 |
| 10 | SAR-Ocean Wave Inversion Using ImageCross Spectra显示文摘 | Engen G Johnsen H | 1995 | IEEE Transactions on Geoscience and RemoteSensing1995，33，4： | 1 |
| 11 | Magneto-optocal Properties of Metallic Ferromagnetic Materials显示文摘 | Buschow K H J van Engen P G Jongebreur R | 1983 | J Magn Magn Mater1983，38，： | 1 |
| 12 | Defying conventional wisdom: A meta-analytical examination of the differences between demographic and job-related diversity re- lationships with performance 显示文摘 | Van Dijk H Van Engen M L Van Knippenberg D | 2012 | Organizational Behavior and Human Decision Processes2012，119，1： | 1 |
| 13 | Retrieval of ocean wave spectra and RAR MTF's from dual polarization SAR data显示文摘 | ENGEN G VACHON P W JOHNSEN H | 2000 | IEEE2000，38，1： | 1 |
| 14 | Transformational, transactional, and laissez-faire leader- ship styles: a meta-analysis comparing women and men 显示文摘 | Eagly A H Johannesen-Sehmidt M C Van Engen M L | 2003 | Psychological Bulletin2003，129，4： | 1 |
| 15 | SAR-ocean Wave Inversion Using Image Cross Spectra显示文摘 | Engen G Johnsen H | 1995 | IEEE Tran Geosci Remote Sensing1995，33，4： | 1 |
| 16 | Directional Wave Spectra by Inversion of ERS-1 Synthetic Aperture Radar Ocean Imagery显示文摘 | Engen G Johnsen H Krogstad H E | 1994 | IEEE Trans On Geoscience and Remote Sensing1994，32，： | 1 |
| 17 | Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria显示文摘 | Engene N Gunasekera S P Gerwick W H | 2013 | Applied and Environmental Microbiology2013，79，6： | 1 |
| 18 | Retrieval of Ocean Wave Spectra and RAR MTF's from Dual-polarization SAR Data显示文摘 | Engen G Vachon P W Johnsen H | 2000 | IEEE Trans Geosci Remote Sensing2000，38，1： | 1 |
| 19 | 显示文摘 | van Engen P G Jongebreur R | 1993 | J Magn Magn Mater1993，38，1： | 1 |
| 20 | Transformational, Transactional, and Laissez-faire Leadership Styles: A meta-analysis Comparing Women and Men 显示文摘 | Eagly A H Johannesen-Schmidt M C Engen M L | 2003 | Psychological Bulletin2003，，： | 1 |
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