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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | A new hybrid electromagnetism-like algorithmfor capacitated vehicle显示文摘 | Alkin Y Erdal E | 2010 | Expert Systems with Applications2010，37，4： | 1 |
| 3 | Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with dif- ferentiation state, motility and invasion显示文摘 | Cokakli M Erdal E Nart D | 2009 | BMC Cancer2009，9，： | 1 |
| 4 | Association between catechol-O-methyhransferase polymorphism and vitiligo显示文摘 | Tursen U Kaya T I Erdal M E | 2002 | Arch Dermatol Res2002，294，3： | 1 |
| 5 | Disclosure of unnoticed rib fractures with the use of ultrasonography in minor blunt chest trauma显示文摘 | Kara M Dikmen E Erdal HH | 2003 | Eur J Cardiothorac Surg2003，24，4： | 1 |
| 6 | Lack of effect of extremely low Frequency electromagnetic fields on cycling-dependent kinase 4 inhibitor gene p18INK4C in electric energy workers显示文摘 | Erdal N Erdal M E Gaargaal S | 2005 | Arch Med Res2005，36，2： | 1 |
| 7 | Lithium-mediated downregula-tion of PKB/Akt and cyclin E with growth inhibition in hepatocellularcarcinoma cells显示文摘 | Erdal E Ozturk N Cagatay T | 2005 | Int J Cancer2005，115，6： | 1 |
| 8 | Eleetrochromie properties of poly(diphenyldithieno thiophene) 显示文摘 | OLCAY M ELIF S ERDAL E | 2006 | Journal of Electroanalytical Chemistry2006，591，1： | 1 |
| 9 | Creutzfeldt-Jaeob Diseases a casereport显示文摘 | Gozke E Erdal N Unal M | 2008 | Cases J2008，1，： | 1 |
| 10 | Serotonin transporter gene olymorphism in irritable bowel syndrome显示文摘 | PATA C ERDAL M E DERICI E | 2002 | Am J Gastroenterol2002，97，： | 1 |
| 11 | Determinants of Foreign Ownership in Turkish Manufacturing 显示文摘 | Tatoglu E Glaister K W Erdal F | 2003 | Eastern European Economics2003，41，2： | 1 |
| 12 | Space-time block coded spatial modulation显示文摘 | BASAR E OMIT A ERDAL PANAYRC | 2011 | IEEE Trans Commun2011，59，3： | 1 |
| 13 | Reprogramming of replicative senescence in hepatocellutar carcinoma-derived cells显示文摘 | Ozturk N Erdal E Mumcuoglu M | 2006 | Proc Natl Acad Sci U S A2006，103，7： | 1 |
| 14 | Serotonin transporter gene polymorphism in irritable bowel syndrome显示文摘 | PATA C ERDAL M E DERICI E | 2002 | Am J Gastroenterology2002，97，： | 1 |
| 15 | Association of the - 1438G/A and 102T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irri- table bowel syndrome 显示文摘 | Pata C Erdal E Yazc K | 2004 | J Clin Gastroenterol2004，38，7： | 1 |
| 16 | Discrete time/cost trade-off problem: A decomposition-based solution algorithm for budget version显示文摘 | OncuHazir M H Erdal E | 2010 | Computers & Operations Research2010，37，3： | 1 |
| 17 | Disclosure of unnoticed rib fractures with the use of ultrasonograghy in minor blunt chest trauma显示文摘 | Kara M Dikmen E Erdal HH | 2003 | Eur J Cardiothorac Surg2003，24，4： | 1 |
| 18 | Association of the-1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome 显示文摘 | Pata C Erdal E Yazc K | 2004 | J Clin Gastroenterol2004，38，7： | 1 |
| 19 | Disclosure of unnoticed rib fractures with the use of ultrasonography in minor blunt chest trauma显示文摘 | Kara M Dikmen E Erdal HH | 2003 | Eur J Cardiothorac Surg2003，24，4： | 1 |
| 20 | Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstruction sleep apnea syndrome显示文摘 | Bayazit YA Yilmaz M Erdal E | 2009 | Eur Arch Otorhinolaryngol2009，266，3： | 1 |
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