|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | A Tabu Search heuristic and adaptive memory procedure for political districting显示文摘 | Bozkaya B Erkut E Laporte G | 2003 | European Journal of Operational Research2003，，144： | 1 |
| 3 | An efficient genetic algorithm for the p-median problem 显示文摘 | Alp O Erkut E Drezner Z | 2003 | Annals of Operations Research2003，122，14： | 1 |
| 4 | Modeling of transport risk for hazardous materials 显示文摘 | Erkut E Veter V | 1998 | Journal of Operations Research1998，46，： | 1 |
| 5 | Designing a road network for b-dous ma- terials shipments 显示文摘 | Erkut E Osman A | 2007 | Computer & Operations Research2007，34，5： | 1 |
| 6 | Designing a road network for hazardous materials shipments显示文摘 | Erhan Erkut Osman Alp | 2007 | Computers Operations &Research2007，，34： | 1 |
| 7 | Modeling of transport risk for hazardous materials 显示文摘 | Erkut E Verter V | 2005 | Operations Reaearch Letters2005，33，1： | 1 |
| 8 | Transport risk models for hazardous materials显示文摘 | Erhan Erkut Armann Ingolfsson | 2005 | revisited Operations Research Letters2005，33，： | 1 |
| 9 | Transport risk models for hazardous materials: Revisited显示文摘 | Erhan Erkut Armann Ingolfsson | 2005 | Operations Research Letters2005，33，1： | 1 |
| 10 | Modeling of transport risk for hazardous materials显示文摘 | ERKUT E VERTER V | | 0，，05： | 1 |
| 11 | Solving the hazmat transport network design problem显示文摘 | ERKUT E GZARA F | | 0，，07： | 1 |
| 12 | Catastrophe avoidance models for hazardous materials route planning显示文摘 | E ERKUT A INGOLFSSON | 2000 | Transportation Science2000，34，2： | 1 |
| 13 | Accurate calculation of hazardous materials transport risk显示文摘 | KARA B Y ERKUT E VETER V | 2003 | Operations Research Letters2003，31，： | 1 |
| 14 | Catastrophe avoidance models for hazardous materials route planning显示文摘 | Erkut E Ingolfsson A | 2000 | Transportation Science2000，34，2： | 1 |
| 15 | The discrete p-dispersion problem显示文摘 | Erkut E | 1990 | European Journal of Operational Research1990，46，： | 1 |
| 16 | Analytical models for locating undesirable facilities显示文摘 | Erkut E Neuman S | 1989 | European Journal of Operational Research1989，40，： | 1 |
| 17 | Transport risk models for hazardous materials: revisited 显示文摘 | Erhan Erkut Armann Ingolfsson | 2005 | Operations Research Letters2005，，33： | 1 |
| 18 | On finding dissimilar paths 显示文摘 | Akgun V Erkut E Batta R | 2000 | European Journal of Operational Research2000，121，： | 1 |
| 19 | Chapter 9 Hazardous Materials Transportation显示文摘 | Erhan Erkut | 2007 | Handbooks in Operations Research and Management Science2007，，： | 1 |
| 20 | Modeling of transport risk for hazardous materials显示文摘 | Erkut E Verter V | 1998 | Operations Research1998，46，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员