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| 1 | Initial sequencing and analysis of the human genome显示文摘 | Lander ES Linton LM Birren B | | 0，，： | 4 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Comparison of the effect of single-dose and multiple-dose methotrexate therapy on tubal patency显示文摘 | Guven ES Dilbaz S Dilbaz B | 2007 | Fertil Steril2007，88，5： | 1 |
| 4 | Experimental behavior of a steel structure under natural fire 显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 5 | Ubiquitous expression of the calcitonin - i gene in multiple tissues in response to sepsis 显示文摘 | Muller B White JC Nylen ES | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 6 | Proangiogenic contribu- tion of adiponectin toward mammary tumor growth in vivo 显示文摘 | Landskroner-Eiger S Qian B Muise ES | 2009 | Clin Cancer Res2009，15，： | 1 |
| 7 | Levels of VEGF but not VEGF165b are Increased in the Vitreous of Patients With Retinal Vein Occlusion显示文摘 | Ehlken C Rennel ES Michels D Grundel B Pielen A Junker B etal | | 0，，： | 1 |
| 8 | Pathophysiological significance of calcitonin precursors in sepsis and sysyemic inflammation显示文摘 | NYHN ES MULLER B SIDER RH et a1 | 1999 | Shock1999，12，1： | 1 |
| 9 | Cytopathology of nipple discharge due to Pityrosporum orbiculare and cocci in an elderly women显示文摘 | Bertini B Kuttin ES Beemer AM | 1975 | Acta Cytol1975，19，1： | 1 |
| 10 | Novel core (polyester) -shell (polysaccharide) nanoparticles:protein loading and surface modification with lectins显示文摘 | Rodrigues J S Santos-Magalhes N S Coelho L C B B | 2003 | J Controlled Release2003，92，12： | 1 |
| 11 | Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition显示文摘 | Su B Diaz-Cmz ES Landini S | 2006 | J Med Chem2006，49，4： | 1 |
| 12 | Treatment of peri-implantitis by the Vector system 显示文摘 | Karring ES Stavropoulos A Ellegaard B | 2005 | Clin Oral Im- plants Res2005，16，3： | 1 |
| 13 | Experimental behavior of a steel structure under natural fire显示文摘 | Wald F Sim?es da Silva L Moore D B | 2006 | Fire Safety Journal2006，41，7： | 1 |
| 14 | Outcome following decompressive craniectomy for malignant swelling due to severe head injury显示文摘 | Aarabi B Hesdorffer DC Ahn ES | 2006 | J of Neurosurgery2006，104，4： | 1 |
| 15 | Association of carotid artery intima-media thickness with complex aortic atherosclerosis in patients with recent stroke 显示文摘 | Fasseas P Brilakis ES Leybishkis B | 2002 | Angiology2002，53，2： | 1 |
| 16 | Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management 显示文摘 | Lynch TJ Jr Kim ES Eaby B | 2007 | Oncologist2007，12，5： | 1 |
| 17 | Bibliotherapy and Perceptions of Death by Young Children显示文摘 | Jeffrey T Thomas ES Michael B | 1998 | Journal of Poetry Therapy1998，12，2： | 1 |
| 18 | Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving par- adigm in clinieal management 显示文摘 | LYNCH TJ KIM ES EABY B | 2007 | Oncologist2007，12，5： | 1 |
| 19 | Risk factors affecting hospital length of stay in patients with odontogenic maxillofacial infections 显示文摘 | Peters ES Fong B Wormuth DW | 1996 | J Oral Maxillofac Surg1996，54，12： | 1 |
| 20 | Miniature Rain Simulator for Measurement of Infiltration and Runoff显示文摘 | Ogden C B Van Es H M Schindelbeck R R | 1997 | Soil Science Society of American Journal1997，61，4： | 1 |
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