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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice显示文摘 | Liu,L Zhang,X Qian,B Min,XY Gao,X Li,CF Cheng,YL Huang,J | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 15 |
| 3 | A method of quantitatively calculating amount of allochthonous organic carbon in lake sediments显示文摘TOTAL organic matter(TOM) or total organic carbon(TOC) is often treated as an importantindicator of lake environment. As a matter of fact, TOC is of multi-origin, and can simply bedivided into two parts: autochthonous and allochthonous organic carbon. The autochthonousorganic carbon is mainly controlled by the production of the plankton of lake itse1f; and the al-lochthonous one by climate and environment in the catchment area, e. g. more precipitationand runoff and densely developed vegetation will give rise to more allochthonous organic com- | Qian, JL Wang, SM Xue, B Chen, RS Ke, SZ | 1997 | Chinese Science Bulletin1997，42，21： | 5 |
| 4 | High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response显示文摘伪 - Galactosylceramide (伪 - GC ) 广泛地被知道激活不变的自然漂亮 T (iNKT ) 压制髓磷脂的房间抗原特定的 Th1 回答,保护易受影响的老鼠免于试验性的自体免疫的脑脊髓炎(EAE ) 。这里,我们表明那高加重,而非改善的伪 - GC 开 EAE 的意外发现。当与高剂量的伪 - GC 对待的 MOG35-55-specific T 房间被变成 na 时,类似的结果被观察 ? ve syngeneic 接受者老鼠。进一步的学习证明伪 - GC 的高剂量直接通过 STAT3 的 phosphorylation 和 NF-魏 B 的激活由 CD4+CD44+ 记忆 T 房间的激活提高 Th17 和 Th1 反应。不同于由伪 - GC 的低剂量的 iNKT 房间的激活,伪 - GC 的高剂量直接交往了, CD1d 在 T 房间上表示了并且激活 Th17 和 Th1 房间。而且,介绍抗原的房间(APC ) 主要表示 CD1d1,而 CD4+ T 房间快车 CD1d2 的多数。由 RNAi 的 CD1d1 或 CD1d2 基因表示击倒分别地防碍 iNKT 或 Th17/Th1 房间的激活。因此,伪 - GC 处理能改善或变得更坏由雇佣取决于剂量的 APC 或 Th17/Th1 房间的 EAE 使用了。 | Gaochao Qian Xia Qin Ying Qin Zang Baoxue Ge Taylor B Guo Bing Wan Lei Fang Jingwu Z Zhang | 2010 | Cell Research2010，20，4： | 3 |
| 5 | Infectious bursal disease virus polyprotein processing does not involve cellular proteases 显示文摘 | Kibenge F S B Qian B Cleghom J R | 1997 | Arch Virol1997，142，： | 1 |
| 6 | Detection of enterotropic mouse hepatitis virus fecal excretion by polymerase chain reaction显示文摘 | Casebolt DB Qian B Stephensen CB | 1997 | Lab Anita Sci1997，47，1： | 1 |
| 7 | A Novel Differential Evolution Algorithm for Bi-criteria No-wait Flow Shop Scheduling Problems显示文摘 | PAN Q K WANG L QIAN B | 2009 | Computers and Operations Research2009，36，8： | 1 |
| 8 | 5-Aminolevulinic acid-based photodynamic therapy显示文摘 | Qian P Trond W Kristian B | 1997 | CANCER1997，79，12： | 1 |
| 9 | Variations of horizontal and vertical velocities over two-dimensional transverse dunes: A wind tunnel simulation of the effect of windward slope显示文摘 | Qian G Q Dong Z B Luo W Y | 2009 | Journal of AridEnvironments2009，73，： | 1 |
| 10 | Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes显示文摘 | Qian T Nieminen AL Herman B | 1997 | Am J Physiol1997，273，： | 1 |
| 11 | Comparative responses of two Kentucky bluegrass cultivars to salinity stress显示文摘 | Qian Y L Wilhelm S J Marcum K B | 2001 | Crop Sci2001，41，： | 1 |
| 12 | Heavy meted contamination and its environmental risk assessment in surface sediments form Lake Dongting, Peo- ple's Republic of China 显示文摘 | Qian Y Zheng M H Gao L Zhang B Liu W Jiao W Zhao X Xiao K | 2005 | Bull Environ Contain Toxicol2005，75，1： | 1 |
| 13 | Federalism as a commitment topreserving market incentives 显示文摘 | Qian Y Weingast B | 1997 | Journal of EconomicPerspectives1997，11，4： | 1 |
| 14 | Complexity of tumor vasculature in clear cell renal cell carcinoma显示文摘 | Qian C N Huang D Wondergem B | 2009 | Cancer2009，115，10： | 1 |
| 15 | Proangiogenic contribu- tion of adiponectin toward mammary tumor growth in vivo 显示文摘 | Landskroner-Eiger S Qian B Muise ES | 2009 | Clin Cancer Res2009，15，： | 1 |
| 16 | A semi-analytical model for truncated-ogive-nose projectiles penetration into semi-infinite concrete targets显示文摘 | Qian L X Yang Y B Liu T | | 0，，： | 1 |
| 17 | Enhancement of oral bioavailability of an HIV-attachment inhibitor by nanosizing and amorphous formulation approaches 显示文摘 | Fakes MG Vakkalagadda B J Qian F | 2009 | Int J Pharm2009，370，12： | 1 |
| 18 | The glass transition and interfacial layer instyrene-butadiene rubber containing silica nanofiller 显示文摘 | Arrighi V MeEwen I J Qian H Serrano P M B | 2003 | Polymer2003，44，： | 1 |
| 19 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 20 | Numerical simula- tion and evaluation of groundwater resources in a frac- tured chalk aquifer: A case study in Zinder well field, Ni- ger显示文摘 | Qian J z Zhou X P Zhan H B | 2014 | Environmental Earth Science2014，72，： | 1 |
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