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| 1 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 2 | Lysosomal pathways to cell death and their therapeutic applications显示文摘 | esen M H Pegan K Spes A | 2012 | Exp Cell Res2012，318，11： | 1 |
| 3 | Comparison of the effects of an adhe- sion barrier and chitin on experimental epidural fibrosis 显示文摘 | Keskin F Esen H | 2010 | Turk Neurosurg2010，20，4： | 1 |
| 4 | An inflammatory verrueous epider- mal nevus concomitant with psoriasis: treatment with adalimumab显示文摘 | Ozdemir M Balevi A Esen H | 2012 | Dermatol Online J2012，18，10： | 1 |
| 5 | Energy and exergy analysis of a ground-coupled heat pump system with two horizontal ground heat exchangers显示文摘 | Esen H Inalli M Esen M | | 0，，10： | 1 |
| 6 | Mammographic Density Increase in Women Receiving Different Hormone Replacement Regimens显示文摘 | Esen G Seyisoglu H | 2001 | Maturitas2001，40，： | 1 |
| 7 | Modeling of a new solar air heater through least squares support vector machine显示文摘 | ESEN H OZGEN F ESEN M | 2009 | Expert Systems with Applications2009，36，10： | 1 |
| 8 | Pituitary dimensions and volume measurements in pregnancy and post partum MR assessment显示文摘 | Dinc H Esen F Demiric A | 1998 | Acta Radiol1998，39，1： | 1 |
| 9 | Response to hepatitis B vaccine in HBsAg/anti-HBs negative and anti HBc positive subjects显示文摘 | Sunbul M Leblebicioglu H Esen S | 2000 | Scand J Infect Dis2000，32，3： | 1 |
| 10 | Impaired right ventricular function in adenotonsillar hypertrophy显示文摘 | DUMAN D NAIBOGLU B ESEN H S | 2008 | Int J Cardiovasc Imaging2008，24，： | 1 |
| 11 | Prevalence of nosocomial infections at intensive care units in Turkey: a multicentre 1-day point prevalence study显示文摘 | Esen S Leblebicioglu H | 2004 | Stand J Infect Dis2004，36，： | 1 |
| 12 | Response to hepati-tis Bvaccine in HBsAg/anti-HBs negative and anti-HBc posi- tive subjeels显示文摘 | Sunbul M Leblebicioglu H Esen S | 2000 | Scand J Infect Dis2000，32，3： | 1 |
| 13 | Modeling of a new solar air heater through least squares support vector machines显示文摘 | Esen H Ozgen F Esen M | | 0，，07： | 1 |
| 14 | Modelling the Size of the Crushed Zone around a Blasthole显示文摘 | ESEN S ONEDERRA I BILGIN H A | 2003 | International Journal of Rock Mechanics and Mining Sciences2003，40，4： | 1 |
| 15 | Experimental thermal performance evaluation of a horizontal ground-source heat pump system 显示文摘 | Inalli M Esen H | 2004 | Applied Thermal Engineering2004，24，14： | 1 |
| 16 | Energy and exergy analysis of a ground-coupled heat pump system with two horizontal ground heat exchangers 显示文摘 | Esen H Inalli M Esen M | 2007 | Building and Environment2007，42，10： | 1 |
| 17 | The role of US and MR imaging in detecting local chest wall tumor recurrence after mastectomy显示文摘 | Yilmaz M H Esen G Ayarcan Y | | 0，，01： | 1 |
| 18 | Surveillance of antimicrobial resistance in gram - negative isolates from ICU in Turkey: analysis of data from the 5 years显示文摘 | Leblebicioglu H Gunaydin M Esen S | 2002 | J Chemother2002，14，： | 1 |
| 19 | Experimental investigation of a two-phase closed thermosyphon solar water heater显示文摘 | Esen M Esen H | 2005 | Solar Energy2005，79，5： | 1 |
| 20 | N-acetylcysteineprevents vasospasm after subarachnoid hemorrhage 显示文摘 | GUNEY 0 ERDI F ESEN H | 2010 | World Neurosurg2010，73，1： | 1 |
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