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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Adventitious shoot regeneration and rooting of Prunus serotina in vitro vultures显示文摘 | ESPINOSA A C PIJUT P M MICHLER C H | 2006 | Hort Science2006，41，1： | 1 |
| 3 | Development and plas-ticity of the primary visual cortex显示文摘 | ESPINOSA J S STRYKER M P | | 0，，02： | 1 |
| 4 | Dynamic duopoly with learning through market experimentation 显示文摘 | Aghion P Espinosa M P Jullien B | 2009 | Economic Theory2009，3，3： | 1 |
| 5 | Binary Path- finder: An improvement to the Pathfinder algorithm显示文摘 | Guerrero-Bote V P Zapico-Alonso F Espinosa M E | 2006 | Information Processing and Management2006，42，6： | 1 |
| 6 | Endogenous formation of competing partnerships with moral hazard显示文摘 | Espinosa M P Macho-Stadler I | 2003 | Games and Economic Behavior2003，44，6： | 1 |
| 7 | The put6 gene of the puromycin biosynthetic gene cluster from Streptomyces alboniger encodes a tyrosinyl-aminonucleoside synthetase显示文摘 | Rubio A M Barrado P Carlos Espinosa J | 2004 | FEBS Lett2004，577，3： | 1 |
| 8 | The horizontal and verti?cal attributes of individualism and collectivism in a Spanish popu?lation显示文摘 | Gouveia VV Clemente M Espinosa P | 2003 | J Soc Psychol2003，143，1： | 1 |
| 9 | Transferrin regulates transcription of the MBP gene and its action synergizes with IGF-1to enhance myelinogenesis in the md rat显示文摘 | Espinosa J A Kumar S Zhao P M | 2002 | Dev Neurosci2002，24，23： | 1 |
| 10 | Modified Coughlin procedure for surgical treatment of symptomatic tailor's bunion: a prospective followup study of 33 consecutive operations 显示文摘 | Vienne P Oesselmann M Espinosa N | 2006 | Foot Ankle Int2006，27，8： | 1 |
| 11 | Catalytic behavior of Co/(Nanoβ-Zeolite) bifunetional catalysts for Fiseher-Tropsch reactions显示文摘 | ESPINOSA G DOMINGUEZ J M MORALES-PACHECO P et al | 2011 | Catalysis Today2011，166，1： | 1 |
| 12 | Should multi-product firms provide divisional or corporate incentives? 显示文摘 | Barcena-Ruiz J C Espinosa M P | 1999 | International Journal of Industrial Organization1999，，17： | 1 |
| 13 | Should muhi-product firms provide divisional or corporate incentives显示文摘 | Barcena-Ruiz J C Espinosa M P | 1999 | International Journal of Industrial Organization1999，17，： | 1 |
| 14 | Electron spin resonance and electronic structure of vanadyl-porphyrin in heavy crude oils 显示文摘 | ESPINOSA P M CAMPERO A SALCEDO R | 2001 | Inorganic Chemistry2001，40，18： | 1 |
| 15 | ERK8,a new member of the mitogen-activated protein kinasefamily显示文摘 | ABE M K SAELZLER M P ESPINOSA RIII | 2002 | JBiol Chem2002，，16： | 1 |
| 16 | Human and rat barin-derived neurotrophic factor and neurotrophin-3:Gene structures,distributions,and chormosomal localization显示文摘 | Maisonpierre P C Beau M M Espinosa R | 1991 | Genomics1991，10，3： | 1 |
| 17 | Fullerenic structures derived from oil asphaltenes显示文摘 | CAMACHO-BRAGADO G A SANTIAGO P MARIN-ALMAZO M ESPINOSA M ROMERO E T MURGICH J RODRIGUEZ LUGO V LOZADA-CASSOU M JOSE-YACAMAN M | 2002 | Carbon2002，40，15： | 1 |
| 18 | Fibrinonecrot-ic typhlitis caused by Escherichia fergusonii in ostriches(Struthio camelus) 显示文摘 | Herrez P Rodrquez A F Espinosa M A | 2005 | Avian Dis2005，49，1： | 1 |
| 19 | Concentration control in alcoholic fermentation processes from ultrasonic velocity measurements显示文摘 | Resa P Elvira L De Espinosa F M | 2004 | Food Research International2004，37，6： | 1 |
| 20 | Identification, molecular characterization and expression analysis of a mucosal Ctype leetin in the eastern oyster, Crassostrea virginica显示文摘 | Jing Xing Espinosa E P Perrigault M | 2011 | Fish Shellfish In munol2011，30，3： | 1 |
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