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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The early detection of nonpalpable breast carcinoma with needle location显示文摘 | Miller R S Ademan R W Espinosa M H | 1992 | Am Surg1992，58，2： | 1 |
| 3 | An overview on the current processes for the recycling of batte - ries 显示文摘 | Espinosa D C R Bemardes A M Teno6rio J A S | 2004 | Journal Power Sources2004，135，： | 1 |
| 4 | Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice显示文摘 | Gonzalez R Hickey M J Espinosa JM | 2007 | Regen Med2007，2，5： | 1 |
| 5 | Mechanistic aspects of hydrogen production by partial oxidation of methanol over Cu/ZnO catalysts 显示文摘 | Espinosa L Lago R M Pena M A | 2003 | Topics in Catalysis2003，22，： | 1 |
| 6 | Mesangial Cdd deposition: a new prognostic factor in IgA nephropathy 显示文摘 | Espinosa M Ortega R Gemez-Carrasco J M | 2009 | Nephrol Dial Transplant2009，24，3： | 1 |
| 7 | An overview on the current processes for the recycling of batteries显示文摘 | Espinosa D C R Bernardes A M Tenorio J A S | 2004 | Journal Power Sources2004，135，： | 1 |
| 8 | The effect of pruning and thinning on above ground aerial biomass of Eucalyptus nitens ( Deane & Maiden ) Maiden 显示文摘 | Munoz F Rnbilar R Espinosa M | 2008 | Forest Ecology and Management2008，255，： | 1 |
| 9 | Plant oils: the perfect renewahle resource for polymer science显示文摘 | ESPINOSA L M D MEIER M A R | 2011 | European Pol- ymer Journal2011，47，5： | 1 |
| 10 | Interaction of rotaviruses with Hsc70 during cell entry is mediated by VPS显示文摘 | Zatate S Cuadras M A Espinosa R | 2003 | J Virol2003，77，13： | 1 |
| 11 | Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q)显示文摘 | Le Beau M M Lemons R S Espinosa R R | 1989 | Blood1989，73，3： | 1 |
| 12 | Infectivity and genome persistence of rotavirus and astrovirus in groundwater and surface water显示文摘 | Espinosa A C Mazari-Hiriart M Espinosa R MaruriAvidal L Méndez E Arias C F | 2008 | Water Res2008，42，1011： | 1 |
| 13 | Analysis of the kinetics of transcription and replication of the rotavirus genome by RNA interference显示文摘 | AYALA B C ARIAS M ESPINOSA R | 2009 | J Virol2009，83，17： | 1 |
| 14 | Enamel deproteinization and its effect on acid etching:an invitro study显示文摘 | Espinosa R Valencia R Uribe M | 2008 | J Clin Pediatr Dent2008，33，1： | 1 |
| 15 | Industrial symbiosis in Puerto Rico: environmentally-related agglomeration economies 显示文摘 | Chertow M R Ashton W S Espinosa J C | 2008 | Region Studies2008，42，10： | 1 |
| 16 | The effect of pruning and thinning on above ground aerial biomass of Eucalyptus nltens (Deane & Maiden) Maiden显示文摘 | Munoz F Rubilar R Espinosa M | 2008 | Forest Ecology and Management2008，255，34： | 1 |
| 17 | De- pletion of the oncoprotein Bel-3 induces centrosome ampli- fication and aneuploidy in can-cer cells 显示文摘 | Zamora R Espinosa M Ceballos-Caneino G | 2010 | Mol Cancer2010，9，： | 1 |
| 18 | Study of trimming damages of CFRP structures in function of the ma- chining processes and their impact on the mechanical behavior 显示文摘 | HADDAD M ZITOUNE R ESPINOSA J | 2014 | Composites Part B: Engineering2014，57，2： | 1 |
| 19 | Influence of the age and drying process on pore structure and sorption isotherms of hardened cement paste显示文摘 | Espinosa R M Franke L | 2006 | Cement and Concrete Research2006，36，10： | 1 |
| 20 | A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY 1, and a myeloid leukemia related gene显示文摘 | Stoffel M Le Beau MM Espinosa R 3rdte al | 1996 | Proc Natl Acad Sci USA1996，93，9： | 1 |
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