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| 1 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 2 | Autoimmune pancreatitis associated with a large pancreatic pseudocyst显示文摘Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, but often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal bile duct requiring repeated stent-ing. Because of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: < 37.0 U/L), the patient underwent explorative laparotomy and pylorus preserving partial pancreaticoduodenectomy. Histology revealed surprisingly AIP with an inflammatory pseudocyst. In conclusion, cyst fluid analysis of tumor markers and cyst fluid cytology lack high accuracy to clearly differentiate cystic pancreatic lesions. Although AIP is rarely associated with pseudocysts, the disease has to be considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures. | Thilo Welsch Jrg Kleeff Irene Esposito Markus W Büchler Helmut Friess | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 3 | Labile plasma iron in iron overload:redox activity and susceptibility to chelation显示文摘 | Esposito BP Breuer W Sirankapracha P | 2003 | Blood2003，102，： | 1 |
| 4 | Plasma adiponectin is decre-ased in nonalcoholic fatty liver disease显示文摘 | Pagano C Soardo G Esposito W etal | 2005 | European journal of en- docrinology / European Federation of Endocrine Societies2005，152，1： | 1 |
| 5 | Plasma adiponectin is decreased in nonalchohohc fatty liver dis-ease显示文摘 | PANAGO C SOSRDO G ESPOSITO W | 2005 | European Journal of Endocrinology2005，152，1： | 1 |
| 6 | Effect of Surface carbon on the hydrogen evolution reactivity of tungsten carbide (WC) and Pt - modified WC cleetroeatalysts 显示文摘 | Kimmel Y C Esposito D V Birkmire R W | 2012 | International Journal of Hydrogen Energy2012，，37： | 1 |
| 7 | Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe,Canada,and the USA:a double-blind,non-inferiority,randomised controlled trial显示文摘 | Cornely O A Crook D W Esposito R | | 0，，4： | 1 |
| 8 | Ambient air and its potential effects on conception in vitro 显示文摘 | Cohen J Gilligan A Esposito W | 1997 | Hum Reprod1997，12，8： | 1 |
| 9 | Plasma adiponectin is decreased in nonalcoholic fatty liver disease显示文摘 | Pagano C Soardo G Esposito W | 2005 | Eur J Endocrinol2005，152，1： | 1 |
| 10 | Anaerobic digestion of rice straw:a review显示文摘 | Mussoline W Esposito G Giordano A | 2013 | Critical Reviews in Environmental Science Technology2013，43，9： | 1 |
| 11 | Plasma adiponectin is decreased in nonalcoholic fatty liver disease显示文摘 | Pagano C Soardo G Esposito W | 2005 | Eurl Endocrinol2005，152，1： | 1 |
| 12 | Labile plasma iron in iron overload: redox activity and susceptibility to chelation 显示文摘 | Esposito BP Breuer W Siraukapracha P | 2003 | Blood2003，102，： | 1 |
| 13 | Reagentless identification of single bacterial spores in aqueous solution by confocal laser tweezers Raman spectroscopy显示文摘 | CHAN J W ESPOSITO A P TALLEY C E | 2004 | Anal Chem2004，76，： | 1 |
| 14 | Electrical energy production and operational strategies from a farm-scale anaerobic batch reactor loaded with rice straw and piggery wastewater显示文摘 | Mussoline W Esposito G Lens P | 2014 | Renewable Energy2014，62，： | 1 |
| 15 | Determination of airborne 1, 6 - hexamethylene diisocyanate by gas chromatography 显示文摘 | ESPOSITO G G DOLZINE T W | 1982 | Analytical Chemistry1982，54，9： | 1 |
| 16 | Determination of airborne 1,6- hexamethylene diisocyanate by gas chromatography显示文摘 | Esposito G G Dolzine T W | 1982 | Analytical Chemistry1982，54，9： | 1 |
| 17 | 自然杀伤细胞的遗传缺失或高反应性不影响动脉粥样硬化发展显示文摘慢性炎症是动脉粥样硬化发展的重要因素,涉及先天免疫和适应性免疫。尽管一些研究已经评估了自然杀伤细胞(natural killer cells,NK)在动脉粥样硬化实验动物模型中的功能,但NK细胞是否可以抑制或促进动脉粥样硬化尚不清楚。先前研究的不足之处在于在靶向丧失或增强NK细胞功能方面缺乏特异性。 | 刘莉 叶鹏 Nour-Eldine W Joffre J Zibara K Giraud A Esposito B Zeboudj L Vilar J Terada M Bruneval P Vivier E Ait-Oufella H Mallat Z Ugolini S Tedgui A | 2017 | 中华高血压杂志2017，25，12： | 1 |
| 18 | Plasma adiponectin is de- creased in nonalcoholic fatty liver disease显示文摘 | Pagano C Soar do G Esposito W | 2005 | Eur J Endocr inol2005，152，1： | 1 |
| 19 | Plasma adiponectin is decreased in nonalcoholic fatty liver disease 显示文摘 | Pagano C Soardo G Esposito W | 2005 | Eur J Endocrinol2005，152，： | 1 |
| 20 | Rotaviruses associate wi cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication 显示文摘 | Cheung W Gill M Esposito A | 2010 | J Virol2010，83，13： | 1 |
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