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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | The gene polymorphism of tumor necrosis factor-β, but not that of tumor necrosis factor-α,is associated with the prognosis of sarcoidosis显示文摘 | Etsuro Y Akihide I Nobuyuki H | 2001 | Chest2001，119，： | 1 |
| 3 | Public capital and economic growth: a conver- gence approach显示文摘 | I Etsuro Shioji | 2001 | Journal of Economic Growth2001，，63： | 1 |
| 4 | The gene polymorphism of tumor necrosis factor-β,but not that of tumor necrosis factor-α,is associated with the prognosis of sarcoidosis显示文摘 | ETSURO Y AKIHIDE I NOBUYUKI H | 2001 | Chest2001，119，4： | 1 |
| 5 | The gene polymorphism of tumor necrosis factor-β,but not that of tumor necrosis factor-α,is associated with the prognosis of sarcoidosis显示文摘 | Etsuro Y Akihide I Nobuyuki H | 2001 | Chest2001，119，： | 1 |
| 6 | Intracellular Ca^2+ concentration change of T24 cell under irradiation in the presence of TiO2 ultrafine particles显示文摘 | Hideki S Etsuro I Ru - xiong C | 1994 | Biochimca et Biophysica Acta (BBA) -General Subjects1994，1201，： | 1 |
| 7 | Clinical response is associated with elevated plasma interleukin-1 receptor antagonist during selective granulocyte apheresis in patients with ulcerative colitis 显示文摘 | KYOYA S TOSHIHIDE O ETSURO I | 2006 | Dig Dis Sci2006，51，： | 1 |
| 8 | The gene polymorphism of tumor necrosis factor-β, but not that of tumor necrosis factor-α,is associated with the prognosis of sarcoidosis显示文摘 | Etsuro Y Akihide I Nobuyuki H | 2001 | Chest2001，119，： | 1 |
| 9 | The gene polymorphism of tumor necrosis factor-β, but not that of tumor necrosis factor-β, is associated with the prognosis of sarcoidosis显示文摘 | Etsuro Y Akihide I Nobuyuki H | 2001 | Chest2001，119，： | 1 |
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