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| 1 | Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17显示文摘 | Agaugué S Carosella ED Rouas-Freiss N | | 0，，26： | 1 |
| 2 | Second order average Hamiltonian theory of symmetry-based pulse schemes in the nuclear magnetic resonance of rotating solids: Application to triple-quantum dipolar recoupling显示文摘 | Brinkmann A Edén M | 2004 | J Chem Phys2004，120，11： | 1 |
| 3 | Residual drift demands in moment‐resisting steel frames subjected to narrow‐band earthquake ground motions显示文摘 | Edén Bojórquez Jorge Ruiz‐García | 2013 | Earthquake Engng Struct Dyn2013，，11： | 1 |
| 4 | Normalized residual displacement spectra for post-mains显示文摘Residual displacement,as a significant measure of structural inelasticity,is effectively used in post-earthquake seismic assessment of structures.This demand can be considered for seismic evaluation of structures under multiple earthquakes.This study introduces a simple and novel index to predict the residual displacement of mainshock-damaged structures against subsequent aftershock.The proposed index is defined as a ratio between residual displacement of damaged structures against aftershock and peak inelastic displacement of intact structures under mainshock.In this study,constantstrength spectra based on the index are developed considering the effects of important structural characteristics and also significant seismic parameters.Moreover,analytical equations are presented to predict the proposed index for bi-linear single-degree-of-freedom(SDOF)systems considering both the effects of positive and negative polarities of aftershock.Furthermore,an equation is suggested to estimate the peak inelastic displacement of intact systems under mainshock,which is required to compute the index. | Saeed Amiri Alireza Garakaninezhad Edén Bojórquez | 2021 | Earthquake Engineering and Engineering Vibration2021，20，2： | 1 |
| 5 | Genes associated with the tumour microenvironment are differentially expressed in cured versus primary chemotherapy -refractory diffuse large B-cell lymphoma显示文摘 | Linderoth J Edén P Ehinger M | 2008 | Br J Haematol2008，141，4： | 1 |
| 6 | Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine显示文摘AIM:To determine the molecular mechanisms involved in experimental hepatic fibrosis prevention by caffeine(CFA).METHODS:Liver fibrosis was induced in Wistar rats by intraperitoneal thioacetamide or bile duct ligation and they were concomitantly treated with CFA(15 mg/kg per day).Fibrosis and inflammatory cell infiltrate were evaluated and classified by Knodell index.Inflammatory infiltrate was quantified by immunohistochemistry(anti-CD11b).Gene expression was analyzed by quantitative reverse transcription-polymerase chain reaction for collagenⅠ?(Col-1),connective tissue growth factor(CTGF),transforming growth factorβ1(TGF-β1),tumor necrosis factor alpha(TNF-α),interleukin-1(IL-1),IL-6,superoxide dismutase(SOD)and catalase(CAT).Activation of Nrf2 and Snail-1 was analyzed by Westernblot.TNF-αexpression was proved by enzyme-linked immunosorbant assay,CAT activity was performed by zymography.RESULTS:CFA treatment diminished fibrosis index in treated animals.The Knodell index showed both lower fibrosis and necroinflammation.Expression of profibrogenic genes CTGF,Col-1 and TGF-β1 and proinflammatory genes TNF-α,IL-6 and IL-1 was substantially diminished with CFA treatment with less CD11b positive areas.Significantly lower values of transcriptional factor Snail-1 were detected in CFA treated rats compared with cirrhotic rats without treatment;in contrast Nrf2was increased in the presence of CFA.Expression of SOD and CAT was greater in animals treated with CFA showing a strong correlation between mRNA expression and enzyme activity.CONCLUSION:Our results suggest that CFA inhibits the transcriptional factor Snail-1,down-regulating profibrogenic genes,and activates Nrf2 inducing antioxidant enzymes system,preventing inflammation and fibrosis. | Daniela Gordillo-Bastidas Edén Oceguera-Contreras Adriana Salazar-Montes Jaime González-Cuevas Luis Daniel Hernández-Ortega Juan Armendáriz-Borunda | 2013 | World Journal of Gastroenterology2013，19，47： | 7 |
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