|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Genetic Structure of an Endangered Plant,Antirrhinum microphyllum (Scrophulariaceae):Allozyme and RAPD Analysis显示文摘 | Elena T Jose M I Cesar P | 2003 | American Journal of Botany2003，90，： | 1 |
| 3 | Recent advances in the friedlander reaction显示文摘 | JOSE M C ELENA P M ABDELOUAHID S | 2009 | Chem Rev2009，109，： | 1 |
| 4 | Luria-delbruck esti- mation of turnip mosaic virus mutation rate in vivo显示文摘 | de la Iglesia F Martinez F Hillung J Cuevas J M Gerrish P J DarOs J A Elena S F | 2012 | Virology2012，86，6： | 1 |
| 5 | Molecular genetics of heat tolerance and heat shock proteins in cereals显示文摘 | Elena M Natalya K Carla P | 2002 | Plant Molec- ular Biology2002，48，： | 1 |
| 6 | Effects of land use on soil inorganiccarbon stocks in the russian chemccem显示文摘 | ELENA A M CHRISTOPHER J P | 2006 | Journal of Environment Quali-ty2006，35，： | 1 |
| 7 | Effect of thermal residual stresses on the matrix failure under trans- verse compression at micromechanical level a nu- merical and experimental study 显示文摘 | Elena C Federico P Vladislav M | 2012 | Composites: Part A2012，43，： | 1 |
| 8 | The combination of fructooligosaccharides and resistant starch shows prebiotic additive effects in rats显示文摘 | Maria Elena Rodríguez-Cabezas Desirée Camuesco Belén Arribas Natividad Garrido-Mesa Mònica Comalada Elvira Bailón Margarita Cueto-Sola Pilar Utrilla Eduardo Guerra-Hernández Carlos Pérez-Roca Julio Gálvez Antonio Zarzuelo | 2010 | Clinical Nutrition2010，，6： | 1 |
| 9 | The mobility and degradation of pesticides in soils and the pollution of groundwater resources显示文摘 | Manuel A E Eugenio L P Elena M C | 2008 | Agriculture Ecosystem and Environment2008，123，： | 1 |
| 10 | Occurrence of patulin and its dietary intake through apple juice consumption by the Spanish population 显示文摘 | Maria M A Susana A Elena G P | 2009 | Food Chem2009，113，2： | 1 |
| 11 | Aflatoxin (B1, B2, G1, and G2) Contamination in Rice of Mexico and Spain, from Local Sources or Imported显示文摘 | Elena Suárez‐Bonnet Magda Carvajal Ignacio Méndez‐Ramírez Pável Castillo‐Urueta Josefina Cortés‐Eslava Sandra Gómez‐Arroyo José María Melero‐Vara | 2013 | Journal of Food Science2013，，11： | 1 |
| 12 | Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity显示文摘 | Shvedova Anna A Fabisiak James P Kisin Elena R Murray Ashley R Roberts Jenny R Tyurina Yulia Y Antonini James M Feng Wei Hong Kommineni Choudari Reynolds Jeffrey Barchowsky Aaron Castranova Vince Kagan Valerian E | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，5： | 1 |
| 13 | Techniques for the removal of marker genes from transgenic plants 显示文摘 | Scutt C P Elena Z Peter M | 2002 | Biochmie2002，84，： | 1 |
| 14 | Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8显示文摘 | Elena Garcí a-Martí n Rosa M Pizarro Carmen Martí nez Yolanda Gutierrez-Martí n Gabriela Pé rez Ramiro Jover José AG Agú ndez | 2006 | Pharmacogenomics2006，，4： | 1 |
| 15 | Recent advances in the Friedlander reaction 显示文摘 | Jose M C Elena P M Abdelouahid S | 2009 | Chem Rev2009，109，： | 1 |
| 16 | Aroylthioureas:new organic ionophores for heavy-metal ion selective electrodes显示文摘 | ELENA O S LEONEL P M OSVALDO E H | 2001 | J Chem Soc Perkin Trans 22001，2，： | 1 |
| 17 | De- lirium: Clinical approach and prevention显示文摘 | Giovanni M Paolo P Elena SM | 2012 | Best Practice & Research Clinical Anaes- thesiology2012，26，3： | 1 |
| 18 | Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue显示文摘 | Anna Aakula Pekka Kohonen Suvi-Katri Leivonen Rami M?kel? Petteri Hintsanen John Patrick Mpindi Elena Martens-Uzunova Tero Aittokallio Guido Jenster Merja Per?l? Olli Kallioniemi P?ivi ?stling | 2015 | European Urology2015，，： | 1 |
| 19 | The mobility and degradation of pesticides in soils and the pollution off ground- water resoureces显示文摘 | Manuel A E Eugenio L P Elena M C | 2008 | Agriculture Ecosystems Environment2008，123，4： | 1 |
| 20 | Pregabalin in the treatment of chronic migraine: An open-label study 显示文摘 | Elena P Calandre Juan M Garcia-Leiva | 2010 | Clin Neu- ropharmacol2010，33，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员