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1篇 您的检索式：作者名="Eleonora Cuboni"

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		题名	作者	年代	出处	被引量
	1	Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance,neuroinflammation and Alzheimer’s disease显示文摘Background:The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer’s dis-ease.It has been proposed that neuroinflammation might be an intervening variable,but the underlying mechanisms are currently unknown.Methods:We utilized primary neurons to induce synaptic insulin resistance as well as a mouse model of high-risk aging that includes a high amyloid load,neuroinflammation,and diet-induced obesity to test hypotheses on underly-ing mechanisms.Results:We found that neddylation and subsequent activation of cullin-RING ligase complexes induced synaptic insulin resistance through ubiquitylation and degradation of the insulin-receptor substrate IRS1 that organizes synap-tic insulin signaling.Accordingly,inhibition of neddylation preserved synaptic insulin signaling and rescued memory deficits in mice with a high amyloid load,which were fed with a’western diet’.Conclusions:Collectively,the data suggest that neddylation and degradation of the insulin-receptor substrate is a nodal point that links high amyloid load,neuroinflammation,and synaptic insulin resistance to cognitive decline and impaired synaptic plasticity in high-risk aging.	Alessandro Dario Confettura Eleonora Cuboni Mohamed Rafeet Ammar Shaobo Jia Guilherme M.Gomes PingAn Yuanxiang Rajeev Raman Tingting Li Katarzyna M.Grochowska Robert Ahrends Anna Karpova Alexander Dityatev Michael R.Kreutz	2022	Translational Neurodegeneration2022，11，1：	0

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