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| 1 | 精子DNA损伤的机制和临床应用显示文摘在男性配子各种不同的DNA异常中,DNA断裂最为常见,尤其是在不育症患者中。目前越来越多的研究表明,DNA断裂并不显著影响精子细胞的存活率、活动率、形态以及与卵细胞的结合能力。研究还证明,卵母细胞在一定程度上可以修复受损的DNA,其修复程度依赖于精子细胞DNA的损伤类型和卵母细胞的质量。因此,研究精子DNA断裂(SDF)在自然分娩或辅助生殖技术助孕中对胚胎发育、胚胎着床、妊娠结果、子代健康的影响变得非常重要。至今,针对SDF对生殖的影响的研究极少,且研究报道的结论很不一致。导致这种不一致的原因可能与检测SDF的手段不同、实验设计不同和精液标本选择标准不同有关。因此,目前还不能确定是否将SDF检测拽术砬用于受精评估和ART技术中。这表明,制定SDF检测技术的标准化方法势在必行,另外关于SDF对ART的影响有必要进行进一步的临床研究。 | Lara Tamburrino Sara Marchiani Margarita Montoya Francesco Elia Marino Ilaria Natali Marta Cambi Gianni Forti Elisabetta Baldi Monica Muratori | 2012 | Asian Journal of Andrology2012，14，1： | 16 |
| 2 | DNA fragmentation in two cytometric sperm populations: relationship with clinical and ultrasound characteristics of the male genital tract显示文摘我们调查了是否在二张 cytometric 精子人口的 DNA 破碎(PI 更暗淡的 和 PI 有不同生物特征和临床的关联的更明亮的 ) 与有关临床并且男生殖道的 color-Doppler 超声(CDUS ) 参数。没有基因畸形的不肥沃的夫妇的 160 男性被评估为临床,阴囊,并且 transrectal CDUS 特征,像前列腺炎的症状的存在(与公民一起,健康长期的前列腺炎症状的研究所索引)并且在 PI 更暗淡的和 PI 更明亮的人口(用 TUNEL/PI ,方法结合了流动 cytometry )。数据好久被调整(模型 1 ) 与腰围,睾丸激素层次,吸烟习惯,和性节制(模型 2 ) 一起。根据统计模型 2, PI 更暗淡的 sDF 与阴囊的畸形被联系,包括降低临床并且超声体积(r = 0.21 并且 r = 0.20 分别地;P < 0.05 ) ,更高的 FSH 层次(r = 0.34, P < 0.0001 ) 并且阴囊的不同类的出现(P < 0.05 ) 并且 hypoechogenicity (P < 0.05 ) 。 PI 更明亮的 sDF 与前列腺相关的症状和反常符号被联系包括全部的更高的 NIH-CPSI 和子域分数,像前列腺炎的症状并且象宏石灰化那样的 CDUS 改变的更高的流行,严重回响质地不同类, hyperemia (所有 P < 0.05 ),并且更高动脉的山峰收缩速度( r = 0.25 , P < 0.05 )。我们的结果在 PI 更暗淡的 精子,与差的精液质量有关,主要在睾丸发源,由于 apoptosis 可能。相反地,在 PI 更明亮的 精子看起来主要通过前列腺发源在期间或在运输以后,与机关的煽动性的地位的存在增加。这些结果能导致新观点让治疗学的目标的鉴定减少 sDF。 | Francesco Lotti Lara Tamburrino Sara Marchiani Elisa Maseroli Pasquale Vitale Gianni Forti Monica Muratori Mario Maggi Elisabetta Baldi | 2017 | Asian Journal of Andrology2017，19，3： | 2 |
| 3 | New insights in sperm biology:How benchside results in the search for molecular markers may help understand male infertility显示文摘The male factor is responsible for about 40% of couple infertility cases and such percentage is expected to increase in the future because of several likely factors including the presence of endocrine disruptors in the environment,changes in lifestyle habits and advanced couple aging.How such factors affect male fertility status,however,should be clarified.Most studies on male fertility status have focused on parameters analyzed using a spermiogram test,the primary diagnostic tool in the routine assessment of male infertility,which is,however,poorly predictive of both natural and medically assisted conception.For these reasons it is mandatory for the scientific community to identify new molecular markers to incorporate into the existing diagnostic tests of male fertility.Ideally,such markers would be detected in mature spermatozoa to avoid invasive procedures for the patient.This review summarizes the recent advancements in benchside approaches that appear most promising for the development of new diagnostic sperm fertility tests,or identification of therapeutic targets,and,illustrates their advantages and limits. | Sara Marchiani Lara Tamburrino Monica Muratori Elisabetta Baldi | 2016 | World Journal of Translational Medicine2016，5，1： | 1 |
| 4 | Decomposition of hexamethylcyclotrisiloxane over solid oxides显示文摘 | ELISABETTA Finocchio GILBERTO Garuti MARCO Baldi | 2008 | Chemosphere2008，72，： | 1 |
| 5 | Remove of siloxane with adsorption 显示文摘 | ELISABETTA Finocchio GILBERTO Garuti MARCO Baldi | 2008 | Chemosphere2008，72，： | 1 |
| 6 | Thiopurine S -methyltransferase pharmacogenetics in a large-scale healthy Italian–Caucasian population: differences in enzyme activity显示文摘 | Loredana Serpe Pier Luigi Calvo Elisabetta Muntoni Sergio D&rsquor Antico Mario Giaccone Alessandra Avagnina Maurizio Baldi Cristiana Barbera Franco Curti Angelo Pera Mario Eandi Gian Paolo Zara Roberto Canaparo | 2009 | Pharmacogenomics2009，，11： | 1 |
| 7 | Discontinuation of and changes in drug therapy for hypertension among newly-treated patients: a population-based study in Italy显示文摘 | Giovanni Corrao Antonella Zambon Andrea Parodi Elisabetta Poluzzi Ileana Baldi Luca Merlino Giancarlo Cesana Giuseppe Mancia | 2008 | Journal of Hypertension2008，，4： | 1 |
| 8 | Genomic and nongenomic effects of estrogens: molecular mechanisms of action and clinical implications for male reproduction显示文摘 | Michaela Luconi Gianni Forti Elisabetta Baldi | 2002 | Journal of Steroid Biochemistry and Molecular Biology2002，，4： | 1 |
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