维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

1篇 您的检索式：作者名="Elise Merritt"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice显示文摘The BRCA1-PALB2-BRCA2 axis,or the BRCA pathway,plays key roles in genome stability maintenance and suppression of breast and several other cancers.Due to frequent p53 mutations in human BRCA1 breast cancers and mouse mammary tumors from Brcal,Brca2 and Palb2 conditional knockout models,it is often thought that p53 inactivation accelerates BRCA1/2 and PALB2-associated tumorigenesis.Here,we studied tumor development in mice with a mutation in Palb2 that disengages the PALB2-BRCA1 interaction in different Trp53 backgrounds.Rather than mammary tumors,Palb2 and Trp53 compound mutant mice developed,with greatly reduced latencies,lymphomas and sarcomas that are typically associated with germline Trp53 inactivation.Whole exome sequencing failed to identify any significant differences in genomic features between the same tumor types of Trp53 single mutant and Palb2;Trp53 compound mutant mice.These results suggest that loss of the BRCA pathway accelerates p53-associated tumor development,possibly without altering the fundamental tumorigenic processes.	Amar H.Mahdi Yanying Huo Ying Chen Pier Selenica Anchal Sharma Elise Merritt Nicola Barnard Chang Chan Shridar Ganesan Jorge S.Reis-Filho Britta Weigelt Subhajyoti De Bing Xia	2022	Genes & Diseases2022，9，3：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费