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| 1 | Duodenal adenocarcinoma: Advances in diagnosis and surgical management显示文摘Duodenal adenocarcinoma is a rare but aggressive malignancy. Given its rarity, previous studies have traditionally combined duodenal adenocarcinoma(DA) with either other periampullary cancers or small bowel adenocarcinomas, limiting the available data to guide treatment decisions. Nevertheless, management primarily involves complete surgical resection when technically feasible. Surgery may require pancreaticoduodenectomy or segmental duodenal resection; either are acceptable options as long as negative margins are achievable and an adequate lymphadenectomy can be performed. Adjuvant chemotherapy and radiation are important components of multi-modality treatment for patients at high risk of recurrence. Further research would benefit from multiinstitutional trials that do not combine DA with other periampullary or small bowel malignancies. The purpose of this article is to perform a comprehensive review of DA with special focus on the surgical management and principles. | Jordan M Cloyd Elizabeth George Brendan C Visser | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 13 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Value of Symptoms to Predict Tilt Testing Outcome in Patients with Clinical Suspicion of Vasovagal Syncope显示文摘 | Maite Vallejo Antonio G. Hermosillo Manlio F. Márquez Alma K. Urquidez Arturo Sotomayor Elizabeth Salas Manuel Cárdenas | 2007 | Archives of Medical Research2007，，5： | 2 |
| 5 | Lead and mercury exposures:interpretation and action显示文摘 | Elizabeth B Ray C Andre M | 2007 | CMAJ2007，176，1： | 1 |
| 6 | Polycyclic aromatic hydrocarbon (PAH) distributions and associations with organic matter in surface waters of the York River,VA Estuary显示文摘 | REBECCA E C REBECCA M D ELIZABETH A C | 2003 | Organic Geochemistry2003，34，： | 1 |
| 7 | The conserved KMN network constitutes the core micmtubule-binding site of the kinetochore显示文摘 | IAIN M C JOSHUA S ELIZABETH M | 2006 | Cell2006，127，： | 1 |
| 8 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 9 | Iron limits the cell division rate of Prochlorococcus in the eastern equatorial Pacific 显示文摘 | Elizabeth L M Sallie W C | 2000 | Limnol Oceanogr2000，45，5： | 1 |
| 10 | Delay T olerant Mobile Networks(DTMNs):Controlled Flooding in Sparse Mobile Networks显示文摘 | Khaled A Kevin C Elizabeth M | 2005 | IFIP Networking2005，，： | 1 |
| 11 | Synonymous cedon usage in Sacharanyces cerevisiae显示文摘 | Paul M S Elizabeth C | 1991 | Yeast1991，，7： | 1 |
| 12 | Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatorymarkers, and clinical outcomes in septic patients: Arandomized, controlled clinical trial 显示文摘 | VERA M B ELIZABETH A CONCEICAO C | 2010 | Crit Care2010，14，： | 1 |
| 13 | Risk of second cancer after treatment of aggressive non-Hodgkin's lymphoma; an EORTC cohort study显示文摘 | Elizabeth C M Noordijk EM Flora EL | 2006 | Haematologica2006，91，11： | 1 |
| 14 | Mul-tiplex Real-Time Reverse Transcription-PCR Assay for Determination of Hepatitis C Virus Genotypes显示文摘 | Linda C Ka WS Elizabeth M | 2006 | J Clin Microbiol2006，41，11： | 1 |
| 15 | The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result form the rapid and prolonged activation of antigen-specific CD8+T cells in vivo显示文摘 | Elizabeth G I Julie M C | 2002 | J Immunol2002，169，： | 1 |
| 16 | Quantatively determined survivin expression levels are of prognostic value in human gliomas显示文摘 | Arnab C Elizabeth N Peter M | 2002 | J Clin Oncol2002，20，4： | 1 |
| 17 | Early occurence of RASSF1A hypermethylatin and its mutual exclusion with BRAF mutation in Thyroid Tumorigenesis 显示文摘 | MINGZHAO X YORAM C ELIZABETH M | 2004 | Cancer Research2004，64，： | 1 |
| 18 | Alpha-tocopherol improves biochemical and dynamic parameters in cryopreserved boar semen显示文摘 | ELIZABETH B BEORLEGUI N B OFLAHERTY C M | | Theriogenology0，63，： | 1 |
| 19 | AIpha-tocopherol improves biochemical and dynamic parame- ters in cryopreserved boar semen 显示文摘 | ELIZABETH B BEORLEGUI N B OFLAHERT C M | 2005 | Theriogenology2005，63，： | 1 |
| 20 | A review of current routing protocols for Ad-Hoe mobile wireless networks显示文摘 | TOH C K | 1999 | IEEE Personal Communications Magazine1999，6，2： | 1 |
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