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| 1 | Cerebral hemodynamics and autoreg- ulation in reversible posterior leukoencephalopathy syndrome caused by pre-/eelampsia 显示文摘 | Oehm E Hctzel A Els T | 2006 | Cerebrovascular Diseases2006,22,23: | 1 |
| 2 | Quantitative fluorescence in situ Hybridization and its ability to predict bladder cancer recurrence and progression to musele-inva-sive cancer 显示文摘 | Kipp B R Tanasescu M Else T A | 2009 | J MolDiagn2009,11,2: | 1 |
| 3 | Oxidative stress reduces Na+/H+ Exchange (NHE) activity in a biliary epithelial cancer cell line (Mz-Cha-1) 显示文摘 | Elsing C Voss A Herrmann T | 2011 | Anticancer Res2011,31,2: | 1 |
| 4 | Oxidative stress reduces Na +/H+ exchange (NHE) activity in a biliary epithelial cancer cell Dine (Mz-Cha-1)显示文摘 | Elsing C Voss A Herrmann T | 2011 | Antieancer Res2011,31,2: | 1 |
| 5 | The regulation of sweet cherry fruit abscission by polar auxin transport显示文摘 | BLANUSA T ELSE M A ATKINSON C J DAVIES W J | 2005 | Plant Growth Regulation2005,45,3: | 1 |
| 6 | Quantitative Fluo- rescence in Situ Hybridization and its Ability to Predict Blad- der Cancer Recurrence and Progression to Muscle- Invasive Bladder Cancer显示文摘 | Kipp B R Tanasescu M Else T A | 2009 | J Mol Diagn2009,11,2: | 1 |
| 7 | Endogenous ABA maintains shoot growth in tomato independently of effects on plant water balance:evidence for an interaction with ethylene显示文摘 | Sharp R E LeNoble M E Else M A Thrne E T Gheradi F | 2000 | J Exp Bot2000,51,: | 1 |
| 8 | Adjuvant thera- pies and patient and tumor characteristics associated with surviv- al of adult patients withadrenocortical carcinoma显示文摘 | ELSE T WILLIAM AR SABOLCH A | 2014 | J Clin En- doerinol Metab2014,99,2: | 1 |
| 9 | Cerebral hemodynamics and auto-regulation in reversible posterior leukoencephalopathy syndrome caused by pre-/eclampsia显示文摘 | Oehm E Hetzel A Els T | 2006 | Cerebrovasc Dis2006,22,: | 1 |
| 10 | Enhancement of transforming growth factor beta 1 expression in the rat pancreas during regeneration from caerulein-induced pancreatitis显示文摘 | Gress T Müller-Pillasch F Els(a)sser HP | | European Journal of Clinical Investigation0,,: | 1 |
| 11 | Adrenoeortical carcinoma 显示文摘 | Else T Kim AC Saboleh A | 2014 | Endocr Rev2014,35,2: | 1 |
| 12 | Evaluation of Th1, Th2 and immunosuppressive cytokine mRNA expression within the colonic mucosa of dogs with idiopathic lymphocytic-plasmacytic colitis显示文摘 | Ridyard A E Nuttall T J Else R W | 2002 | Vet Immunol Immunopathol2002,86,34: | 1 |
| 13 | Repetitive cerulein-induced pancreatitis and pancreatie fibrosis in the rat显示文摘 | Els(a)sser HP Haake T Grimmig M | 1992 | Pancreas1992,7,3: | 1 |
| 14 | Applicability of an enzymatic time temperature integrator as a quality indicator for mushrooms in the distribution chain显示文摘 | Els Bobelyn Maarten L A T M Hertog and Bart M Nicolai | 2006 | Postharvest Biology and Technology2006,42,1: | 1 |
| 15 | Applicability of an Enzymatic Time Temperature Integrator as a Quality Indicator for Mushrooms in the Distribution Chain显示文摘 | BOBELYN Els MAARTEN L A T M Hertog NICOLA Bart M | 2006 | Postharvest Biology and Technology2006,42,: | 1 |
| 16 | Stomatal closure in flooded tomato plants involves abscisic acid and a chemically unidentified antitranspirant in xylem sap 显示文摘 | ELSE M A TIEKSTRA A E CROKOR S T | 1996 | Plant Physiol1996,112,: | 1 |
| 17 | 月桂酰乳酰乳酸钠对感染亚临床产气荚膜梭菌肉鸡生产性能和肠道健康的影响显示文摘产气荚膜梭菌属革兰氏阳性菌,是一种家禽肠道致病菌。由于产气荚膜梭菌亚临床感染常导致肠黏膜损害,降低营养物质的消化,降低生产性能,应采取一种有效的措施控制产气荚膜梭菌的过度生长。为此,本文旨在研究月桂酰乳酰乳酸钠作为一种饲料添加剂防止产气荚膜梭菌在肉鸡肠道内定植(LauL)的药效测定。首先,将月桂酰乳酰乳酸钠与感染产气荚膜梭菌肉鸡的月桂酸单体甘油二脂(MDG)和月桂酸游离脂肪酸(LauL)相比,产气荚膜梭菌损害度16分的结果表明,MDG和LauL两者都有降低损害程度的效果。考虑到体增重和死亡率,LauL比MDG更有效。因此,剂量反应研究目的是确定最佳LauL添加量。试验结果表明,LauL的剂量高于15%,对损害度和死亡率起到预期的积极作用。不添加任何剂量的LauL,生长性能较好。在第3次试验中,将LauL的效果与限制肠道内细菌活性的商业化产品(Aromabiotic波尔60)或限制球虫病的细菌(化学抗球虫药,Clinacox)相比。该产品并没有减少损害的数目和严重程度,且对生产性能无影响。因此,尽管在试验1和试验2中,高于0.15%剂量的LauL产生了显著的作用效果,但是添加月桂酰乳酰乳酸钠并不能降低产气荚膜梭菌在肉鸡体内的定植,故在试验3中并未产生效果。但为进一步研讨月桂酰乳酰乳酸钠作为潜在的添加剂对减少肉鸡产气荚膜梭菌激发的免疫反应的研究,提供了科学依据。 | Lensing M Vander K J D Fabri T Cazemier A Else A J | 2011 | 饲料博览2011,,2: | 0 |
| 18 | 氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病(LRF CLL4试验)的评价:一项随机对照试验显示文摘背景既往研究报道了氟达拉滨联合环磷酰胺治疗慢性淋巴细胞白血病(CLL)有较高的反应率。本文作者旨在确定这种联合治疗方案与单用氟达拉滨或苯丁酸氮芥治疗相比,是否更有益于患者的存活。
方法将777例需要治疗的CLL患者随机分配入氟达拉滨组(n=194)或氟达拉滨联合环磷酰胺组(n=196),共治疗6个疗程;或者苯丁酸氮芥组(n=387),治疗12个疗程。主要终点指标为总体存活率,次要终点指标为治疗反应率、无进展存活时间、毒性反应及生活质量。采用意向治疗分析。研究注册为一项国际标准化随机对照试验,编码NCT 58585610。
结果氟达拉滨联合环磷酰胺组、氟达拉滨组以及苯丁酸氮芥组之间,总体存活率均无显著性差异。氟达拉滨联合环磷酰胺组在完全反应率和总体反应率方面优于氟达拉滨组(两组完全反应率分别为38%和15%,P〈0.0001;总体反应率分别为94%和80%,P〈0.0001),更优于苯丁酸氮芥组(该组完全反应率为7%,P=0.006;总体反应率为72%,P=0.04)。5年无进展存活率氟达拉滨联合环磷酰胺组(36%)明显优于氟达拉滨组(10%)和苯丁酸氮芥组(10%,P〈0.0005)。在各年龄亚组,包括年龄〉70岁的患者中,氟达拉滨联合环磷酰胺被证实是最佳治疗方案。在通过免疫球蛋白重链基因(Vn)突变状态(533例)与细胞遗传学(579例)判断的各预后组中,氟达拉滨联合环磷酰胺组也是最佳联合方案。但氟达拉滨联合环磷酰胺组和氟达拉滨组中,中性粒细胞减少的发生率和住院天数高于苯丁酸氮芥组。溶血性贫血的发生率在氟达拉滨联合环磷酰胺组最低(5%),氟达拉滨组为11%,苯丁酸氮芥组为12%。对治疗有反应的患者生活质量较好,但初步分析显示各组间并无显著性差异。关于本研究和其他两项已发表的Ⅲ期,临床试验资料的荟萃分析显示氟达拉滨联合环磷酰胺治疗对患者的无进展存活有一致益处。
结论氟达拉滨联合环磷酰胺应成为目前CLL的标准治疗方案,也应成为加用单克隆抗体治疗方案的基础。 | D Cotovsky S Richords E Matutes D Oscier M J S Dyer R F Bezores A R Pettitt T Hamblin D W Milligon J A Child M S Hamilton C E Dearden A G Smith A G Bosanquet Z Davis V Brito-Babapulle M Else R Wade P Hillmen 季杰(译) | 2008 | 世界临床医学2008,2,1: | 0 |
| 19 | 月桂酰乳酰乳酸钠对感染亚临床产气荚膜梭菌肉鸡生产性能和肠道健康的影响显示文摘产气荚膜梭茵属革兰氏阳性菌,是一种家禽肠道致病菌。由于产气荚膜梭菌亚临床感染常导致肠黏膜损害,降低营养物质的消化,降低生产性能,应采取一种有效的措施控制产气荚膜梭茵的过度生长。 | Lensing M Van der Klis J D Fabri T Cazemier A Else A J | 2010 | 饲料博览2010,,12: | 0 |