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您的检索式：作者名="Emma C.L.Cook"
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| 1 | Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity显示文摘Conventional dendritic cells(cDCs)scan and integrate environmental cues in almost every tissue,including exogenous metabolic signals.While cDCs are critical in maintaining immune balance,their role in preserving energy homeostasis is unclear.Here,we showed that Batf3-deficient mice lacking conventional type 1 DCs(cDC1s)had increased body weight and adiposity during aging.This led to impaired energy expenditure and glucose tolerance,insulin resistance,dyslipidemia,and liver steatosis.cDC1 deficiency caused adipose tissue inflammation that was preceded by a paucity of NK1.1+invariant NKT(iNKT)cells.Accordingly,among antigen-presenting cells,cDC1s exhibited notable induction of IFN-γproduction by iNKT cells,which plays a metabolically protective role in lean adipose tissue.Flt3L treatment,which expands the dendritic cell(DC)compartment,mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent manner.This effect was partially mediated by NK1.1+cells.These results reveal a new critical role for the cDC1-iNKT cell axis in the regulation of adipose tissue homeostasis. | Elena Hernández-García Francisco J.Cueto Emma C.L.Cook Ana Redondo-Urzainqui Sara Charro-Zanca Iñaki Robles-Vera Ruth Conde-Garrosa Ivana Nikolić Guadalupe Sabio David Sancho Salvador Iborra | 2022 | Cellular & Molecular Immunology2022，19，2： | 0 |
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