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| 1 | Gut microbiota imbalance and colorectal cancer显示文摘The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies. | Johan Gagnière Jennifer Raisch Julie Veziant Nicolas Barnich Richard Bonnet Emmanuel Buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet | 2016 | World Journal of Gastroenterology2016，22，2： | 76 |
| 2 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 3 | Presence of three dengue serotypes in Ouagadougou(Burkina Faso):research and public health implications显示文摘Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity impacts.Methods:An exploratory cross-sectional survey was performed from December 2013 to January 2014.Six primary healthcare centers in Ouagadougou were selected based on previously reported presence of Flavivirus.All patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to participate.Sociodemographic data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a questionnaire.Blood samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)analysis.In a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and described.Larvae were collected and brought to the laboratory to monitor the emergence of adults and identify the species.Results:Of the 379 subjects,8.7%(33/379)had positive RDTs for dengue.Following the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory testing.Of 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were positive.The serotypes observed were DENV2,DENV3,and DENV4.Odds of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under five.Average total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.Potential Aedes breeding sites were found near 71.4%(21/28)of patients,but no adult Aedes were found.The most frequently identified potential breeding sites were water storage containers(45.2%).Most specimens collected in yards were Culex(97.9%).Conclusions:The scientific community,public health authorities,and health workers should consider dengue as a possible cause of febrile illness in Burkina Faso. | Valéry Ridde Isabelle Agier Emmanuel Bonnet Mabel Carabali Kounbobr Roch Dabiré Florence Fournet Antarou Ly Ivlabèhiré Bertrand Meda Beatriz Parra | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | Urodynamic analysis in multiple system atrophy: characterisation of detrusor-sphincter dyssynergia显示文摘 | Frédéric Bloch Bertrand Pichon Anne-Marie Bonnet Jacques Pichon Marie Vidailhet Emmanuel Roze Michel Perrigot | 2010 | Journal of Neurology2010，，12： | 1 |
| 5 | Effects of Nonsteroidal Antiinflammatory Drugs on Patient-controlled Analgesia Morphine Side Effects: Meta-analysis of Randomized Controlled Trials显示文摘 | Emmanuel Marret Okba Kurdi Paul Zufferey Francis Bonnet | 2005 | Anesthesiology2005，，6： | 1 |
| 6 | Effect of motivational mobile phone short message service on aspirin adherence after coronary stenting for acute coronary syndrome显示文摘 | Jacques Quilici Lionel Fugon Shirley Beguin Pierre Emmanuel Morange Jean-Louis Bonnet Marie-Christine Alessi Patrizia Carrieri Thomas Cuisset | 2013 | International Journal of Cardiology2013，，： | 1 |
| 7 | A new class of epoxy thermosets 显示文摘 | Emmanuel G R Pascault J P Bonnet A | 2003 | Macromolecular Symposia2003，198，1： | 1 |
| 8 | A New Class of Epoxy Thermosets 显示文摘 | Emmanuel G R Pascault J P Bonnet A | 2003 | Macromolecular Symposia2003，198，1： | 1 |
| 9 | CYP2C19*2 and *17 Alleles Have a Significant Impact on Platelet Response and Bleeding Risk in Patients Treated With Prasugrel After Acute Coronary Syndrome显示文摘 | Thomas Cuisset Marie Loosveld Pierre Emmanuel Morange Jacques Quilici Pierre Julien Moro Noémie Saut Bénédicte Gaborit Christel Castelli Shirley Beguin Charlotte Grosdidier Laurent Fourcade Jean-Louis Bonnet Marie-Christine Alessi | 2012 | JACC: Cardiovascular Interventions2012，，12： | 1 |
| 10 | Analgesic efficacy and adverse effects of epidural morphine compared to parenteral opioids after elective caesarean section: A systematic review显示文摘 | Marie-Pierre Bonnet Alexandre Mignon Jean-Xavier Mazoit Yves Ozier Emmanuel Marret | 2010 | European Journal of Pain2010，，9： | 1 |
| 11 | Overview of Identification Methods of Mechanical Parameters Based on Full-field Measurements显示文摘 | Stéphane Avril Marc Bonnet Anne-Sophie Bretelle Michel Grédiac Fran?ois Hild Patrick Ienny Félix Latourte Didier Lemosse Stéphane Pagano Emmanuel Pagnacco Fabrice Pierron | 2008 | Experimental Mechanics2008，，4： | 1 |
| 12 | β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells显示文摘 | Jenny Yeung Maria Teresa Esposito Arnaud Gandillet Bernd B. Zeisig Emmanuel Griessinger Dominique Bonnet Chi Wai Eric So | 2010 | Cancer Cell2010，，6： | 1 |
| 13 | Impact of a community-based intervention on Aedes aegypti and its spatial distribution in Ouagadougou,Burkina Faso显示文摘Background:Several studies highlighted the impact of community-based interventions whose purpose was to reduce the vectors’breeding sites.These strategies are particularly interesting in low-and-middle-income countries which may find it difficult to sustainably assume the cost of insecticide-based interventions.In this case study we determine the spatial distribution of a community-based intervention for dengue vector control using different entomological indices.The objective was to evaluate locally where the intervention was most effective,using spatial analysis methods that are too often neglected in impact assessments.Methods:Two neighbourhoods,Tampouy and Juvenat in Ouagadougou,Burkina Faso,were chosen among five after a survey was conducted,as part of an assessment related to the burden of dengue.As part of the communitybased intervention conducted in Tampouy between August and early October 2016,an entomological survey was implemented in two phases.The first phase consisted of a baseline entomological characterization of potential breeding sites in the neighbourhood of Tampouy as well as in Juvenat,the control area.This phase was conducted in October 2015 at the end of the rainy season.The mosquito breeding sites were screened in randomly selected houses:206 in Tampouy and 203 in Juvenat.A second phase took place after the intervention,in October 2016.The mosquito breeding sites were investigated in the same yards as during the baseline phase.We performed several entomological analyses to measure site productivity as well as before and after analysis using multilevel linear regression.We used Local Indicators of Spatial Association(LISAs)to analyse spatial concentrations of larvae.Results:After the intervention,it is noted that LISAs at Tampouy reveal few aggregates of all types and the suppression of those existing before the intervention.The analysis therefore reveals that the intervention made it possible to reduce the number of concentration areas of high and low values of pupae.Conclusions:The contribution of spatial methods for assessing community-based intervention are relevant for monitoring at local levels as a complement to epidemiological analyses conducted within neighbourhoods.They are useful,therefore,not only for assessment but also for establishing interventions.This study shows that spatial analyses also have their place in population health intervention research. | Emmanuel Bonnet Florence Fournet Tarik Benmarhnia Samiratou Ouedraogo Roch Dabiré Valéry Ridde | 2020 | Infectious Diseases of Poverty2020，9，3： | 0 |
| 14 | Effective surveillance systems for vectorborne diseases in urban settings and translation of the data into action:a scoping review显示文摘Background:Vector-borne diseases(VBDs)continue to represent a global threat,with“old”diseases like malaria,and“emergent”or“re-emergent”ones like Zika,because of an increase in international trade,demographic growth,and rapid urbanization.In this era of globalization,surveillance is a key element in controlling VBDs in urban settings,but surveillance alone cannot solve the problem.A review of experiences is of interest to examine other solution elements.The objectives were to assess the different means of VBD surveillance in urban environments,to evaluate their potential for supporting public health actions,and to describe the tools used for public health actions,the constraints they face,and the research and health action gaps to be filled.Main body:For this scoping review we searched peer-reviewed articles and grey literature published between 2000 and 2016.Various tools were used for data coding and extraction.A quality assessment was done for each study reviewed,and descriptive characteristics and data on implementation process and transferability were analyzed in all studies.After screening 414 full-text articles,we retained a total of 79 articles for review.The main targets of the articles were arboviral diseases(65.8%)and malaria(16.5%).The positive aspects of many studies fit within the framework of integrated vector management.Public awareness is considered a key to successful vector control programs.Advocacy and legislation can reinforce both empowerment and capacity building.These can be achieved by collaboration within the health sector and with other sectors.Research is needed to develop well designed studies and new tools for surveillance and control.Conclusions:The need for surveillance systems in urban settings in both developing and developed countries was highlighted.Countries face the same challenges relating to human,financial,and structural resources.These findings also constitute a wake-up call for governments,academia,funders,and World Health Organization to strengthen control programs and enhance VBD research in urban environments. | Florence Fournet Frederic Jourdain Emmanuel Bonnet Stephanie Degroote Valery Ridde | 2018 | Infectious Diseases of Poverty2018，7，1： | 0 |
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